Serum Cystatin C and Coronavirus Disease 2019: A Potential Inflammatory Biomarker in Predicting Critical Illness and Mortality for Adult PatientsResearch Article Published on 2020-10-082022-10-31 Journal: Mediators of Inflammation [Category] COVID-19, MERS, SARS, [키워드] adjusted adverse outcome analyses baseline baseline level Chronic kidney disease coronavirus disease COVID-19 COVID-19 patient COVID-19 patients Critically ill cystatin C death highest Hospitalization illness Inflammatory inflammatory conditions laboratory data Logistic regression marker organ dysfunction outcome p value Patient patients with COVID-19 Potential predict Prognostic value quartile risk serum significantly [DOI] 10.1155/2020/3764515 PMC 바로가기 [Article Type] Research Article
A brief review on potential application of mesenchymal stem cell and secretome in combating mortality and morbidity in COVID-19 patientsReview Published on 2020-09-282023-07-01 Journal: Biomedical journal [Category] SARS, [키워드] COVID-19 Mesenchymal stem cells organ dysfunction respiratory distress SARS-CoV2 Secretome [DOI] 10.1016/j.bj.2020.09.003 PMC 바로가기 [Article Type] Review
Lactate Kinetics Reflect Organ Dysfunction and Are Associated with Adverse Outcomes in Intensive Care Unit Patients with COVID-19 Pneumonia: Preliminary Results from a GREEK Single-Centre StudyArticle Published on 2020-09-282022-10-30 Journal: Metabolites [Category] COVID-19, [키워드] acute respiratory distress syndrome Admission Adverse Analysis APACHE II applied association Blood calculated clinical outcomes Cohort Course COVID-19 COVID-19 patient COVID-19 patients Cox regression analysis Health ICU ICU admission ICU Patients Increased independent initial intensive care intensive care unit Kinetics Lactate Mortality non-survivor organ dysfunction Organ failure outcome Patient Pneumonia Result retrospective SOFA SOFA score survivor was measured with COVID-19 [DOI] 10.3390/metabo10100386 PMC 바로가기 [Article Type] Article
The spectrum of biochemical alterations associated with organ dysfunction and inflammatory status and their association with disease outcomes in severe COVID-19: A longitudinal cohort and time-series design studyResearch article Published on 2020-09-202022-10-05 Journal: EClinicalMedicine [Category] 유전자 메커니즘, [키워드] 95% CI abnormality Acute kidney injury AKI alteration ARF association biochemical biochemical marker biochemical markers carried Cohort consecutive patient CRP dataset death disease Evolution finding Follow-up highlight Inflammatory Inflammatory marker inflammatory reaction inflammatory status iterations kidney lack liver longitudinal cohort study lung marker Occurrence Odds ratio organ dysfunction outcome outcomes pancreas Patient patients predict proportion renal dysfunction Respiratory failure retrospective risk risk of COVID-19 risk of death severe COVID-19 severity significantly syndrome urea nitrogen [DOI] 10.1016/j.eclinm.2020.100554 [Article Type] Research article
The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19Research article Published on 2020-09-062022-10-05 Journal: Cell [Category] SARS, 유전자 메커니즘, [키워드] acute COVID-19 acute respiratory syndrome Analysis Asymptomatic autoantibodies autoantibody autoimmune etiology Biomarker blood immune cells children coronavirus COVID-19 Cytokines elevated enrolled feature Fever healthy children hyperinflammation in children IL-17A infected with SARS-CoV-2 Infection Inflammation Inflammatory Inflammatory response involved Kawasaki disease marker Mild MIS-C multisystem inflammatory syndrome in children organ dysfunction overlapping Pathogenesis presenting SARS-CoV-2 syndrome systems immunology T cell the cytokine storm Vasculitis with COVID-19 [DOI] 10.1016/j.cell.2020.09.016 [Article Type] Research article
Clinical Characteristics and Outcomes of Severe and Critical Patients With 2019 Novel Coronavirus Disease (COVID-19) in Wenzhou: A Retrospective StudyMedicine Published on 2020-09-042022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] 2019 novel coronavirus 28-day mortality Acute cardiac injury Acute kidney injury Acute liver injury ARDS Blood urea nitrogen cardiac chest CT scan clinical Clinical characteristics Confirmed COVID-19 infection consolidation COVID-19 COVID-19 infection Critical Critically ill develop diastolic died disease dysfunction early stage echocardiography ECMO enrolled extracorporeal membrane oxygenation GGO Ground glass opacity hospital Hospitalization increased cardiac output Infection Invasive mechanical ventilation less liver dysfunction lung involvement Manifestations men Mortality Most patient non-invasive ventilation novel Older organ dysfunction outcome Patient Platelet positive Prone position renal replacement therapy retrospective cohort study RT-PCR Severe case severe patients severity suffered treated Ventilation [DOI] 10.3389/fmed.2020.552002 PMC 바로가기 [Article Type] Medicine
Death due to Cardiac Arrest in a Young Female With Highly Suspected COVID-19: A Case ReportInfectious Disease Published on 2020-08-302022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute cor pulmonale advanced age arrest Atypical cardiac Cardiac arrest cardiovascular disease Case report clinical presentation Coagulopathy COVID-19 COVID-19 patient CTPA D-dimer values Diabetes Mellitus Diagnosis died disease echocardiographic false-negative feature female healthy higher risk hypertension Lung disease Mortality organ dysfunction pandemic coronavirus Patient patients with COVID-19 Pneumonia pulmonary angiography Pulmonary embolism report risk factor RT-PCR severe COVID-19 significant increase Suspected Swab Thromboembolism Young younger patient [DOI] 10.7759/cureus.10127 PMC 바로가기 [Article Type] Infectious Disease
Impact of Shenfu injection on a composite of organ dysfunction development in critically ill patients with coronavirus disease 2019 (COVID-19): A structured summary of a study protocol for a randomized controlled trialLetter Published on 2020-08-242022-10-29 Journal: Trials [Category] COVID-19, MERS, [키워드] 1:1 28-day mortality 48 hours adopted allergic allergy allocation concealment alveolar baseline bleeding blinded Blinding block randomization both group breastfeeding women caused China Chinese clinical clinical trial conducted control group coronavirus disease COVID-19 criteria Critical Critically ill patient death defined determine Diagnosis dissemination distribution element enrolled enrolment event exacerbated expected HIV hospital hospital cost ICU immunosuppressive drug Impact incidence include increase in injection intensive care Length lung malignant tumor management guideline multicenter National Health Commission number objective Obstructive Open-label organ organ dysfunction Organ failure outcome parallel group participant Patient patient recruitment patients patients with COVID-19 Pneumonia pregnant primary endpoint protocol provided pulmonary interstitial fibrosis random randomised randomised controlled trial randomization Randomized Randomized controlled trial Randomly receive recruit recruited researchers Sample size SAS sealed secondary endpoint Sepsis Seven severe malnutrition severity Shenfu injection shown SOFA SOFA score statistical status study group Study protocol supportive therapy the patient Total treat Treatment Two-arm underlying disease usual care vasoactive drug Volume website [DOI] 10.1186/s13063-020-04677-5 PMC 바로가기 [Article Type] Letter
Multi-centre, three arm, randomized controlled trial on the use of methylprednisolone and unfractionated heparin in critically ill ventilated patients with pneumonia from SARS-CoV-2 infection: A structured summary of a study protocol for a randomised controlled trialLetter Published on 2020-08-172022-10-29 Journal: Trials [Category] Coronavirus, MERS, [키워드] 24 hour absolute reduction Administered administration AIFA airway allocation sequence Alpha Anticoagulant anticoagulant therapy Anticoagulant treatment approval Arm Aspergillus assigned assumption average bleeding bleeding event blinded Block randomisation block size BMI Brain Breastfeeding Candida checked childbearing age chronic clinical clinical condition clinically combined use conjunctival contributed corpus Corticosteroid COVID-19 criteria Critical Critically ill cytomegalovirus D-dimer level death defined Delay detect diagnostic discharge dissemination dosage drug dysfunction effective element eligible patient enoxaparin enrolled EudraCT exclusion criteria expected hematemesis hematoma heparin-induced thrombocytopenia Herpe high risk High-dose history hospital hospital discharge Hypothesis ICU ICU free day ICU Patients impairing Inclusion inclusion criteria indicated Infection initial Inpatient intensive care unit interval Intervention Intra-articular intramuscular intravenously invasive Invasive mechanical ventilation investigator Italian limit LMWH low molecular weight low-molecular weight heparin macroscopic major bleeding mechanical ventilation medical intervention Methylprednisolone Mortality mortality rate Myocardial Non-invasive non-invasive ventilation number objective occur ophthalmic organ dysfunction PaO parallel group participant Patient performed Pharyngeal swab Pneumonia positive positive pressure pregnancy test Presence Prophylactic prophylactic dose Prophylaxis protocol random randomisation randomised randomised controlled trial randomization Randomized Randomized controlled trial Randomly Ratio receive recent recruited recruitment Rectal Bleeding red blood cell reduce reducing Registered required risk of death Safety Sample size SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pneumonia secondary secure severe disease sick significantly sodium status steroid stratified stroke study drug Study protocol subcutaneously surgical syndrome therapeutic therapeutic doses therapy Treatment treatment group unfractionated heparin Venous Thromboembolism ventilated patient Ventilation website Weighting Withdrawal women [DOI] 10.1186/s13063-020-04645-z PMC 바로가기 [Article Type] Letter
Clinical Characteristics and Risk Factors for Disease Severity and Death in Patients With Coronavirus Disease 2019 in Wuhan, ChinaMedicine Published on 2020-08-132022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] Admission age CD19 CD3 CD4 CD4 cell Cell clinical clinical manifestation collected data Comorbidities Comorbidity conducted COVID-19 COVID-19 case Cox model Cytokines D-dimer death Deterioration diabete died disease deterioration elevated Factor Fever High-sensitivity C-reactive protein hypertension IL-10 IL-6 immune response immune responses Inflammation interleukin-10 IQR lactate dehydrogenase LDH Leukocytosis lymphocyte lymphopenia manifestation men Neurological symptom neutrophil Next-generation sequencing Older age organ dysfunction outcome Patient patients Pneumonia progressed progression progression of disease Renmin Hospital respiratory symptom Retrospective study risk factor Risk factors RT-PCR severity statistical analysis the disease the median university Wuhan Wuhan, China [DOI] 10.3389/fmed.2020.00532 PMC 바로가기 [Article Type] Medicine