Hyperactivated RAGE in Comorbidities as a Risk Factor for Severe COVID-19—The Role of RAGE-RAS Crosstalk심한 Covid-19의 위험 요소로서 동반 질환의 과잉 활성화 분노-Rage-Ras Crosstalk의 역할Review Published on 2021-06-122022-09-01 Journal: Biomolecules [Category] MERS, SARS, 진단, [키워드] AGER polymorphisms angiotensin appear Comorbidity COVID-19 comorbidities COVID-19 patients Crosstalk deleterious effect deleterious effects Factor Hyperactivation Infection Inflammation Inflammatory Ligand molecular target multiligand receptor multiorgan injury oxidative stress Pathologies Patient polymorphism RAGE RAS receptor renin–angiotensin system reported role SARS-CoV-2 severe COVID-19 therapeutic [DOI] 10.3390/biom11060876 PMC 바로가기 [Article Type] Review
SARS-CoV-2 Envelope (E) protein interacts with PDZ-domain-2 of host tight junction protein ZO1SARS-COV-2 엔벨로프 (E) 단백질은 숙주 단단한 접합 단백질 ZO1의 PDZ- 도메인 -2와 상호 작용한다.Research Article Published on 2021-06-092022-08-13 Journal: PLoS ONE [Category] Biochemistry, MERS, SARS, 변종, 진단, [키워드] airway amplified approach approaches array binding Biotin C-terminal cell layer chloride complementary consolidation contribute contributing to COVID-19 patients disease severity domain dysfunction E protein ECT envelope epithelial epithelial cell epithelial cells epithelial tissues extreme Fluorescence fusion protein global pandemic homogenous Host HTRF humans interact Interaction Intervention lead Lungs membrane protein mitigate molecular morbidity motif multifunctional mutant Pathogenesis Pathologies peptide Protein reduce respiratory Respiratory disease respiratory tract SARS-CoV-1 SARS-CoV-2 screened secretion sequence severe pneumonia severe respiratory disease singular target the lungs a the SARS-CoV-2 tight junction tissues virus virus spread Zona [DOI] 10.1371/journal.pone.0251955 PMC 바로가기 [Article Type] Research Article
National survey on the treatment of acute appendicitis in Spain during the initial period of the COVID-19 pandemicResearch article Published on 2021-06-012022-10-05 Journal: Cirugia española [Category] 치료법, [키워드] Acute appendicitis AEC affected Appendicitis approach carried Conservative management COVID-19 COVID-19 pandemic Google hospitals incidence initial knowledge management National pandemic Pathologies patients protocol questionnaire reducing resource response Result SARS-CoV-2 Spain Spanish surgeon surgical survey treat Treatment [DOI] 10.1016/j.cireng.2021.05.009 [Article Type] Research article
Extracellular Vesicles: Versatile Nanomediators, Potential Biomarkers and Therapeutic Agents in Atherosclerosis and COVID-19-Related Thrombosis세포외 소포: 죽상경화증 및 COVID-19 관련 혈전증에서 다목적 나노매개체, 잠재적 바이오마커 및 치료제Review Published on 2021-05-312022-09-10 Journal: International Journal of Molecular Sciences [Category] 바이오마커, [키워드] agent atherogenesis Atherosclerosis atherosclerotic Biomarker Biomarkers cardiovascular disease cardiovascular diseases cargo Cell cells Characteristics coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient cytoplasmic proteins DNA Effect endocytosis endothelial EVs Exosomes extracellular vesicle Extracellular vesicles immune cells information mechanism mediators Mesenchymal stromal cells metabolites microRNA Microvesicles mRNA participant pathological condition Pathologies Platelets Potential receptors Signaling stromal cells therapeutic agents therapeutic potential thrombosis thrombotic Thrombotic events transfer variety [DOI] 10.3390/ijms22115967 PMC 바로가기 [Article Type] Review
The Impact of and Adaptations Due to the COVID-19 Pandemic on the Histopathological Diagnosis of Skin Pathologies, Including Non-Melanocyte and Melanoma Skin Cancers—A Single-Center Study in RomaniaArticle Published on 2021-05-272022-10-30 Journal: Medicina [Category] COVID-19, SARS, [키워드] adaptation affected analyzed Cancer Cell changes in clinical COVID-19 COVID-19 pandemic decrease diagnose diagnoses diagnostic Frequency health system histopathological Histopathology hospital Impact Including malignancy material Melanoma Non-COVID-19 non-melanocytic cancers objective pandemic Pathologies performed radical excision Result Romania skin skin biopsy Tumor variable [DOI] 10.3390/medicina57060533 PMC 바로가기 [Article Type] Article
SARS-CoV-2: One Year in the Pandemic. What Have We Learned, the New Vaccine Era and the Threat of SARS-CoV-2 VariantsReview Published on 2021-05-272022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] ACE2 cardiovascular diseases caused changed coronavirus coronavirus disease COVID 19 COVID19 deaths diabetes effort hypertension Infection kinin-kallikrein system knowledge mechanism molecular New outcome pandemic Pandemics Pathologies PROTECT question Renin angiotensin aldosterone system Research risk SARS-CoV-2 Spread threat Vaccine Year [DOI] 10.3390/biomedicines9060611 PMC 바로가기 [Article Type] Review
Swarm Learning for decentralized and confidential clinical machine learningArticle Published on 2021-05-262022-10-04 Journal: Nature [Category] Fulltext, MERS, 유전자 메커니즘, 진단, [키워드] accelerate addition approach blood transcriptome Chest X-ray images chose Classifier clinical study Computational models Control coordinator COVID-19 develop Diagnostic markers disease distribution facilitate feasibility heterogeneous illness learning Local lung machine learning machine-learning other disease outperform Pathologies Patient Precision Predictive medicine Regulation Tuberculosis viral infection [DOI] 10.1038/s41586-021-03583-3 PMC 바로가기 [Article Type] Article
An effect of the COVID-19 pandemic: Significantly more complicated appendicitis due to delayed presentation of patients!Research Article Published on 2021-05-252022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] 2020 COVID-19 pandemic affected analyzed Antibiotic treatment Antibiotics Appendicitis Characteristics collected COVID-19 COVID-19 pandemic database duration of symptom evaluated Hospital stay Hospitalization initial symptom Intervention lockdown Novel coronavirus pandemic Pathologies Patient postoperative Practitioner presenting proportion Result significant difference significant increase surgical symptom onset These data two groups [DOI] 10.1371/journal.pone.0249171 PMC 바로가기 [Article Type] Research Article
Protein kinase CK2: a potential therapeutic target for diverse human diseases단백질 키나제 CK2: 다양한 인간 질병에 대한 잠재적인 치료 표적Review Published on 2021-05-172022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 변종, [키워드] addition Atherosclerosis Autoimmune disorders bases best Cancer cardiac hypertrophy cardiac ischemia cardiovascular diseases Control COVID-19 pandemic cystic fibrosis diabetes Drug development effective inhibitor ENhance evaluate fibrosis function host cell host proteins human disease human diseases human infections Hypothesis implicated increasingly induce Inflammation Injury life cycle Medicinal chemistry Mutation Neurological diseases obesity ophthalmic Other Pathologies pathology pharmacological target phosphorylate Phosphorylation plethora potential therapeutic target Protein protein kinase psychiatric disorder Psychiatric disorders recent findings regulate reperfusion injury responsible SARS-CoV-2 signaling pathways substrate substrates syndrome Target identification therapy Viral virus viruses [DOI] 10.1038/s41392-021-00567-7 PMC 바로가기 [Article Type] Review
Defective NET clearance contributes to sustained FXII activation in COVID-19-associated pulmonary thrombo-inflammation결함 있는 NET 제거는 COVID-19 관련 폐 혈전 염증에서 지속적인 FXII 활성화에 기여합니다Research paper Published on 2021-05-142022-09-11 Journal: EBioMedicine [Category] 유전자 메커니즘, [키워드] accumulation Activation activity alveolar alveolar spaces Analysis clearance clinical Coagulation coagulation factor Coagulopathy Contact contribute coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients DNase Donor European expression Extracellular factor XII FIBRIN finding foundation funding FXII hallmark hallmarks Hamburg healthy control immunostaining in vitro increased mortality Inflammation leads lung lung parenchyma lung tissue mechanism NET NETs neutrophil Neutrophil extracellular trap Neutrophil extracellular traps offer pathogenic Pathologies Patient performed plasma sample plasma samples procoagulant Proinflammatory response proteomic Proteomic analysis Pulmonary thrombo-inflammation reduced Support supported sustained targeting therapeutic strategy thrombosis union vasculature was increased [DOI] 10.1016/j.ebiom.2021.103382 PMC 바로가기 [Article Type] Research paper