Cytokine/Chemokine Expression Is Closely Associated Disease Severity of Human Adenovirus Infections in Immunocompetent Adults and Predicts Disease ProgressionImmunology Published on 2021-06-072022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, 신종인플루엔자, [키워드] “cytokine storm” acute respiratory disease acute respiratory distress alanine aminotransferase ALT analyses analyzed ARDS Aspartate aminotransferase AST AUC AUC value Bacteria Biomarker caused characteristic characterized Combination coronavirus Cytokine storm cytokine/chemokine expression disease Disease progression disease severity expression H1N1 healthy controls hepatocyte growth factor HGF highest Human human adenoviruses IFN-γ IL-10 IL-1α IL-1β IL-6 immunocompetent adults Increasing Infection infections interferon M-CSF MIG occurred outcome oxygen pandemic PaO Patient patients patients with ARDS plasma sample predict prediction Prevalence profile progression reached reported ROC SARS-CoV-2 significantly significantly higher syndrome Viremia were measured [DOI] 10.3389/fimmu.2021.691879 PMC 바로가기 [Article Type] Immunology
Serological profiles of pan-coronavirus-specific responses in COVID-19 patients using a multiplexed electro-chemiluminescence-based testing platform다중 전기 화학 발광 기반 테스트 플랫폼을 사용한 COVID-19 환자에서 Pan-Coronavirus 특이 적 반응의 혈청 학적 프로파일Research Article Published on 2021-06-032022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 치료법, [키워드] antibody Antibody Response antibody response against Antibody responses carried collected Contact tracing COVID-19 COVID-19 patient COVID-19 sample COVID-19 samples CoVs cross-reactive cross-reactivity diagnosed with COVID-19 Diagnosis diagnostic domain epitope epitope specificity full-length spike protein group healthcare HKU1 hospital human coronavirus human CoV human CoVs IgG response IgG responses IgM and IgG IgM response IgM responses MERS MERS-CoV Multiplex assay N-terminal domain Non-COVID-19 nucleocapsid protein OC43 occur plasma sample plasma samples platform Prevalence profile Protein reactivity Receptor-binding domain reported response responses robust SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 nucleocapsid SARS-CoV-2 spike protein seasonal coronavirus serological assessment South South Korea specificity Spike protein Spike proteins subject Symptom the SARS-CoV-2 the spike protein unique [DOI] 10.1371/journal.pone.0252628 PMC 바로가기 [Article Type] Research Article
A luciferase immunosorbent assay for quantitative detection of IgG antibodies against SARS-CoV-2 nucleoproteinSARS-CoV-2 핵단백질에 대한 IgG 항체의 정량적 검출을 위한 루시퍼라제 면역흡착 분석법Article Published on 2021-06-012022-09-11 Journal: Journal of virological methods [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] addition against SARS-CoV anti-SARS-CoV-2 antibody Antibody detection Blood donors cell lysate COVID-19 patient COVID-19 patients cross-reactivity enzyme evaluated expected expressing furimazine fused healthy blood donors IgG antibody immunosorbent limit of detection linear luciferase Luciferase immunosorbent assay MERS MERS-CoV monoclonal antibodies monoclonal antibody murine Nanoluc luciferase plasma sample plasma samples Protein protein G Quantitative SARS-CoV spike protein SARS-CoV-2 SARS-CoV-2 nucleoprotein Semi-quantitative. sensitivity serum specificity spike Spike protein [DOI] 10.1016/j.jviromet.2021.114141 PMC 바로가기 [Article Type] Article
Lack of antibodies against seasonal coronavirus OC43 nucleocapsid protein identifies patients at risk of critical COVID-19계절성 코로나바이러스 OC43 뉴클레오캡시드 단백질에 대한 항체 부족으로 심각한 COVID-19 위험에 처한 환자 식별Multicenter Study Published on 2021-06-012022-09-11 Journal: Journal of Clinical Virology [Category] MERS, SARS, 진단, 치료법, [키워드] adjusted adjusted odds ratio age Analysis analyzed antibody AOR benefit BMI Care conducted coronavirus Course COVID-19 COVID-19 patient Critical Critical disease disease examined females France Germany HCoV HCoV 229E HKU1 human coronavirus human coronaviruses ICU identify IgG antibodies IgG antibody immunoblot increased risk individual Infection Inpatient majority Male sex males median age Mild Mild disease morbidity and mortality Multivariate analysis NL63 nucleocapsid protein OC43 Patient plasma sample PROTECT risk Risk assessment risk factor risk stratification SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections seasonal seasonal coronavirus serostatus serum Sex significantly lower specific antibodies symptom onset tested vaccination [DOI] 10.1016/j.jcv.2021.104847 PMC 바로가기 [Article Type] Multicenter Study
A novel LC-MS/MS method for determination of the potential antiviral candidate favipiravir for the emergency treatment of SARS-CoV-2 virus in human plasma: Application to a bioequivalence study in Egyptian human volunteers인간 혈장에서 SARS-CoV-2 바이러스의 긴급 치료를 위한 잠재적인 항바이러스 후보 favipiravir의 결정을 위한 새로운 LC-MS/MS 방법: 이집트 인간 지원자의 생물학적 동등성 연구에 적용Article Published on 2021-05-302022-09-11 Journal: Journal of pharmaceutical and biomedical analysis [Category] SARS, 치료제, [키워드] acetic acetic acid adopted Antiviral antiviral agent application applied bioanalysis Bioequivalence Bioequivalence study composed Concentration COVID-19 Eclipse electrospray ionization Favipiravir flow rate healthy Human Human plasma isocratic LC–MS/MS Linear regression linearity m/z mass spectrometer methanol pharmacokinetic plasma sample positive protein precipitation pumped pyrazinamide quantification SARS-CoV-2 SARS-CoV-2 virus simple Treatment US-FDA Volunteer volunteers was used [DOI] 10.1016/j.jpba.2021.114057 PMC 바로가기 [Article Type] Article
Antibody Responses and Clinical Outcomes in Adults Hospitalized With Severe Coronavirus Disease 2019 (COVID-19): A Post hoc Analysis of LOTUS China Trial중증 코로나바이러스 질환 2019(COVID-19)로 입원한 성인의 항체 반응 및 임상 결과: LOTUS China 임상시험의 사후 분석Article Published on 2021-05-182022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 진단, 치료법, [키워드] 95% CI 95% confidence interval adjusted adverse outcome analyzed antibody Antibody titers Antigen Chain Reaction Characteristics China clinical Clinical improvement Clinical outcome clinical outcomes collected coronavirus disease Coronavirus disease 2019 correlated correlation COVID-19 COVID-19 patients death determined by ELISA enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay humoral Humoral response IgG IgG antibodies IgG antibody IgG titers IgM immunoglobulin M less linear mixed model LOTUS China microneutralization Microneutralization assay NAb NAbs Neutralizing Neutralizing antibodies neutralizing antibody nonsurvivor nonsurvivors nucleocapsid Patient plasma plasma sample polymerase chain polymerase chain reaction Protein random effect RBD reached Real-Time Reverse Transcription Polymerase Chain Reaction Receptor-binding domain response reverse transcription reverse transcription polymerase chain reaction RT-PCR severe coronavirus disease severe COVID-19 severe COVID-19 patient slope Spike protein statistical survivor symptoms onset the receptor-binding domain throat swab throat swabs Trial Viral viral clearance Viral load was determined were measured [DOI] 10.1093/cid/ciaa1247 PMC 바로가기 [Article Type] Article
Defective NET clearance contributes to sustained FXII activation in COVID-19-associated pulmonary thrombo-inflammation결함 있는 NET 제거는 COVID-19 관련 폐 혈전 염증에서 지속적인 FXII 활성화에 기여합니다Research paper Published on 2021-05-142022-09-11 Journal: EBioMedicine [Category] 유전자 메커니즘, [키워드] accumulation Activation activity alveolar alveolar spaces Analysis clearance clinical Coagulation coagulation factor Coagulopathy Contact contribute coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients DNase Donor European expression Extracellular factor XII FIBRIN finding foundation funding FXII hallmark hallmarks Hamburg healthy control immunostaining in vitro increased mortality Inflammation leads lung lung parenchyma lung tissue mechanism NET NETs neutrophil Neutrophil extracellular trap Neutrophil extracellular traps offer pathogenic Pathologies Patient performed plasma sample plasma samples procoagulant Proinflammatory response proteomic Proteomic analysis Pulmonary thrombo-inflammation reduced Support supported sustained targeting therapeutic strategy thrombosis union vasculature was increased [DOI] 10.1016/j.ebiom.2021.103382 PMC 바로가기 [Article Type] Research paper
Pulmonary Procoagulant and Innate Immune Responses in Critically Ill COVID-19 Patients중환자 COVID-19 환자의 폐 응고 촉진제 및 선천성 면역 반응Clinical Trial Published on 2021-05-142022-09-12 Journal: Frontiers in Immunology [Category] SARS, 임상, 진단, [키워드] activated Activation acute respiratory distress Antigen Biomarker bronchoalveolar Bronchoalveolar lavage fluid bronchoalveolar space C1-Inhibitor CD40 ligand chemokine Coagulation complement complexes COVID-19 COVID-19 patient Critically ill Cytokines declined domain evaluate FIVE Follow-up functional growth factor Growth factors healthy controls host response Ill implicated Inflammatory Inflammatory response inhibitor Innate innate immune response Local lung measurement mechanical ventilation mechanism objective P-selectin pathogenesis of COVID-19 pathway Patient patients patients with COVID-19 persistent ARDS plasma plasma sample procoagulant pulmonary rationale response Result severe COVID-19 significantly increased stratified syndrome systemic tissue type I ventilated patient were measured with COVID-19 [DOI] 10.3389/fimmu.2021.664209 PMC 바로가기 [Article Type] Clinical Trial
High Levels of the Cleaved Form of Galectin-9 and Osteopontin in the Plasma Are Associated with Inflammatory Markers That Reflect the Severity of COVID-19 Pneumonia혈장 내 갈렉틴-9 및 오스테오폰틴의 높은 수준은 COVID-19 폐렴의 중증도를 반영하는 염증 마커와 관련이 있습니다Article Published on 2021-05-072022-09-10 Journal: International Journal of Molecular Sciences [Category] 바이오마커, 진단, [키워드] Analysis association Bacterial infection C-reactive protein can be used cleaved Coagulopathy coronavirus disease Coronavirus disease 2019 Correlation analysis COVID pneumonia COVID-19 COVID-19 patient CP group CP patient CP patients elevated ferritin followed by form full-length full-length galectin-9 full-length osteopontin Galectin-9 healthy individuals highest Infectious diseases Inflammation inflammatory biomarkers inflammatory markers interleukin Kidney function Laboratory Level Lung function marker mild clinical symptom mild clinical symptoms MONITOR number osteopontin Patient Plasma level Plasma levels plasma sample plasma samples Pneumonia Proteases Protein reduced ROC analysis severity significantly Spearman’s correlation suggested therapeutic effect therapeutic effects therapy Tocilizumab treated truncated galectin-9 undefined osteopontin [DOI] 10.3390/ijms22094978 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Viremia is Associated With Inflammatory, But Not Cardiovascular Biomarkers, in Patients Hospitalized for COVID-19SARS-CoV-2 바이러스혈증은 COVID-19로 입원한 환자의 심혈관 바이오마커가 아닌 염증성 질환과 관련이 있습니다Observational Study Published on 2021-05-042022-08-31 Journal: Journal of the American Heart Association [Category] MERS, SARS, 바이오마커, 임상, 치료기술, [키워드] association baseline Biobank Biomarker Biomarkers C-reactive protein cardiac troponin cardiac troponin T cardiovascular collected comparable Concentration concentrations COVID COVID-19 COVID‐19 cTnT D-dimer diabetes Diabetes Mellitus dimer Elevation elevations ferritin had more Hospitalization hospitalized patient hospitalized patients infection with SARS-CoV-2 Inflammatory Inflammatory biomarker interleukin interleukin-6 laboratory-confirmed lower oxygen saturation Manifestations mechanical ventilation men Myocardial dysfunction myocardial injury N-terminal N-terminal pro-B-type natriuretic peptide NT-proBNP observational study occur oxygen Patient patients peptide plasma plasma sample prevalent procalcitonin Registration Result RNA SARS-CoV-2 SARS-CoV-2 RNA SARS‐CoV‐2 Stress symptoms of COVID-19 tissue troponin T variety Viremia white [DOI] 10.1161/JAHA.120.019756 PMC 바로가기 [Article Type] Observational Study