potential therapeutic target – Page 11 – Communicable Diseases Research

The emerging role of cellular senescence in complications of COVID-19

COVID-19의 합병증에서 세포 노화의 새로운 역할

Review

Published on 2021-01-012022-09-12
Journal: Cancer treatment and research communications [Category] MERS, 진단,

In-depth blood proteome profiling analysis revealed distinct functional characteristics of plasma proteins between severe and non-severe COVID-19 patients

심층 혈액 프로테옴 프로파일링 분석은 중증 코로나19 환자와 그렇지 않은 COVID-19 환자 사이에서 혈장 단백질의 뚜렷한 기능적 특성을 밝혀냈습니다.

Article

Published on 2020-12-292022-09-10
Journal: Scientific Reports [Category] MERS, SARS, 바이오마커,

[키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis Biomarker Blood Candidates Characteristics Clinical outcome complement Complement activation coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Critical case critical cases develop differentially expressed disease severity downstream eight Factor functional highlighting host response IMPROVE Infectious diseases interleukin interleukin-6 mortality rate Necrosis neutrophil neutrophil activation Patient patients worldwide performed plasma plasma protein Platelet potential therapeutic target potential therapeutic targets predict profiling analysis Prognosis prognostic biomarker Prognostic markers proinflammatory Protein Proteins proteome proteomic Proteomic analysis proteomics quantified reported respiratory SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severity of COVID-19 Support T cell Tumor tumor necrosis tumor necrosis factor upstream
[DOI] 10.1038/s41598-020-80120-8 PMC 바로가기 [Article Type] Article

Protease-activated receptor 1 as a potential therapeutic target for COVID-19

Minireview

Published on 2020-12-102022-10-31
Journal: Experimental Biology and Medicine [Category] COVID-19, MERS, SARS,

[키워드] acute respiratory distress Anticoagulant anticoagulation caused clinical symptom Coagulation Coagulopathy coronavirus COVID-19 diarrhea disease Dizziness dry cough Dyspnea endothelial Fever headache Immune-mediated include Inflammation management mechanism Novel coronavirus pathophysiology Patient physiological poor prognosis potential therapeutic target prevalent proinflammatory cytokines Protease-activated receptor 1 Proteases prothrombotic state receptor Regulation Respiratory disease SARS-CoV-2 severe COVID-19 Spread supportive care syndrome the disease thrombin thrombin receptor thrombosis tissue damage Treatment Vaccine vomiting weakness Wuhan, China
[DOI] 10.1177/1535370220978372 PMC 바로가기 [Article Type] Minireview

SARS-CoV-2-triggered neutrophil extracellular traps mediate COVID-19 pathology

Article

Published on 2020-12-072022-10-06
Journal: The Journal of Experimental Medicine [Category] SARS, 진단,

[키워드] acute respiratory distress angiotensin-converting enzyme 2 Autopsy cell death Cohort Concentration COVID-19 COVID-19 pathology COVID-19 patient COVID-19 patients Cytokine storm syndrome death described detrimental develop diagnosis of COVID-19 enrolled healthy healthy control hospitalized patient in vitro induce Inflammatory diseases investigated involved lung lung epithelial NET NETs neutrophil Neutrophil extracellular trap Neutrophils organ dysfunction pathophysiology plasma potential therapeutic target promote released SARS-CoV-2 serine protease syndrome tissue tissue damage tracheal triggered virus replication
[DOI] 10.1084/jem.20201129 PMC 바로가기 [Article Type] Article

Vascular Disease and Thrombosis in SARS-CoV-2-Infected Rhesus Macaques

SARS-CoV-2에 감염된 붉은털 원숭이의 혈관 질환 및 혈전증

Case Reports

Published on 2020-11-252022-09-11
Journal: Cell [Category] MERS, SARS, 유전자 메커니즘, 진단,

[키워드] Analysis Bronchoalveolar lavage C-reactive protein clinical Clinical features Coagulation collagen complement COVID-19 COVID-19 pandemic Critical endothelial feature Human IFNα IL-1 IL-6 IL-8 include infected with SARS-CoV-2 Inflammation Inflammatory Interaction lead lung Lungs macaque macaques Macrophage molecular morbidity and mortality MX1 NF-κB pathway performed Peripheral blood Platelet platelet activation potential therapeutic target potential therapeutic targets proinflammatory proteomic rhesus macaque rhesus macaques SARS-CoV-2 SARS-CoV-2 pathogenesis serum thrombosis TNFα transcriptomic Transcriptomic analyses upregulation Vascular vascular disease vascular thrombosis vWF
[DOI] 10.1016/j.cell.2020.10.005 PMC 바로가기 [Article Type] Case Reports

Lung Protection by Cathepsin C Inhibition: A New Hope for COVID-19 and ARDS?

카텝신 C 억제에 의한 폐 보호: COVID-19 및 ARDS에 대한 새로운 희망?

Review

Published on 2020-11-252022-09-11
Journal: Journal of medicinal chemistry [Category] 신약개발, 임상,

[키워드] activate acute respiratory distress acute respiratory distress syndrome alveolar inflammation appear ARDS Autoimmune diseases cathepsin Cathepsin C clinical trials contribute COVID-19 COVID-19 pandemic COVID-19 patients cysteine deficiency Depletion Effect Elastase Elimination evaluated Hope impair Inflammatory inhibitor intensive care unit intensive care units life Lung injury neutrophil Neutrophils New outbreak Patient patients potential therapeutic target Prevent progression proinflammatory protease Proteases protection pulmonary failure reduce respiratory distress Respiratory distress syndrome Serine serine proteases syndrome therapeutic strategy tissue degradation
[DOI] 10.1021/acs.jmedchem.0c00776 PMC 바로가기 [Article Type] Review

Prothrombotic autoantibodies in serum from patients hospitalized with COVID-19

COVID-19로 입원한 환자의 혈청 내 전혈성 자가항체

Research Article

Published on 2020-11-182022-09-10
Journal: Science Translational Medicine [Category] 진단, 치료제,

[키워드] accelerated activated neutrophil Activation antibodies antibody antibody level antibody levels antiphospholipid antibodies autoantibodies autoantibody Autoimmune diseases blood vessel blood vessels Case series Casting circulating Coagulation coagulation pathway COVID-19 COVID-19 patient serum Cutoff develop eight ELISA FIBRIN filtration rate fraction glomerular filtration rate glycoprotein healthy individuals high risk Histopathology hyperactivity IgG IgG and IgM IgM in vitro injected injection Lung histopathology Lupus mice Mouse models NET NETs neutrophil Neutrophil extracellular trap Neutrophil extracellular traps Neutrophils Occlusion pathogenic pathogenic autoantibodies pathogenic autoantibody pathway Patient patients patients hospitalized patients with COVID-19 phenotype phospholipid Phospholipids Platelet platelet counts positive potential therapeutic target potentially life-threatening promoted Protein prothrombin prothrombotic purified respiratory Respiratory disease reveal serum serum sample serum samples severe COVID-19 severe respiratory disease small blood vessel small blood vessels syndrome the disease threshold Thrombophilia thrombosis thrombotic venous Venous thrombosis with COVID-19
[DOI] 10.1126/scitranslmed.abd3876 PMC 바로가기 [Article Type] Research Article

Computational Analysis of Targeting SARS-CoV-2, Viral Entry Proteins ACE2 and TMPRSS2, and Interferon Genes by Host MicroRNAs

Communication

Published on 2020-11-162022-10-31
Journal: Genes [Category] COVID-19, SARS,

[키워드] 3′-UTR 5′-UTR ACE2 acute respiratory syndrome Algorithm binding site biological plausibility Biomarkers cell lines Combination coronavirus coronavirus disease COVID-19 Critical dataset global pandemic health care systems host miRNA identify IFN IFN-α infected cells interactions Local mechanism microRNA miR-29a miRNA miRNA profiling miRNAs mRNA transcript ORF potential therapeutic target predict predicted proteins ACE2 provide Rapid regulated Regulatory responsible RNA RNA viruses SARS-CoV-2 SARS-CoV-2-infected cell Spread targeting the interferon the SARS-CoV-2 genome TMPRSS2 upstream viral entry viral pathogenesis virus
[DOI] 10.3390/genes11111354 PMC 바로가기 [Article Type] Communication

Transcriptional and proteomic insights into the host response in fatal COVID-19 cases

치명적인 COVID-19 사례의 숙주 반응에 대한 전사 및 단백질 분석

Case Reports

Published on 2020-11-102022-09-10
Journal: Proceedings of the National Academy of Sciences of [Category] MERS, SARS, 유전자 메커니즘, 진단,

[키워드] active viral infection Analysis cathepsin caused changes in clinical Colon colonic coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease COVID-19-related death death died disease pathogenesis disease severity drug target examination expressed fatal COVID-19 feature fibrosis finding First wave fulminant infection global pandemic greater Host host response host responses human lung tissue immune immunological impacted Infection Inflammatory Inflammatory response lung lung parenchyma lung tissue majority molecular NETosis neutrophil neutrophil activation nine offer pandemic Pathogenesis pathophysiology pathway Pathways Patient patients with COVID-19 potential therapeutic target potential therapeutic targets primary site protease Proteins proteome proteomic proteomics pulmonary fibrosis Respiratory failure response S100A8 SARS-CoV-2 SARS-COV-2 infection severe COVID-19 disease severe SARS severe SARS-CoV-2 Significance suggested the patient the SARS-CoV-2 transcriptional Transcriptome up-regulated Viral viral burden viral infection Wuhan Wuhan, China
[DOI] 10.1073/pnas.2018030117 PMC 바로가기 [Article Type] Case Reports

The SARS-CoV-2 Conserved Macrodomain Is a Mono-ADP-Ribosylhydrolase

Structure and Assembly

Published on 2020-11-062022-10-30
Journal: Journal of Virology [Category] COVID-19,

[키워드] activity acute respiratory syndrome addition ADP-ribose ADP-ribosylation affinity animal model Antiviral approved bind binding Biochemistry caused complex Compound conserved coronavirus CoV CoV infection COVID-19 Critical death demonstrated domain ELISAs enzyme enzyme activity enzyme-linked immunosorbent assay functions host response hydrolysis increasingly Mac1 macrodomain MAR MERS-CoV Middle East Modification mono-ADP-ribose nonstructural protein 3 Nsp3 Pathogenesis poly-ADP-ribose potential therapeutic target potential therapy Protein Proteins reagent regulate respiratory syndrome coronavirus SARS-CoV SARS-CoV-2 SARS-related CoV target proteins the SARS-CoV-2 therapeutic strategy therapeutic target unique viral infection viral infections virulence worldwide pandemic
[DOI] 10.1128/JVI.01969-20 PMC 바로가기 [Article Type] Structure and Assembly