A Third Dose of an Inactivated Vaccine Dramatically Increased the Levels and Decay Times of Anti-SARS-CoV-2 Antibodies, but Disappointingly Declined Again: A Prospective, Longitudinal, Cohort Study at 18 Serial Time Points Over 368 Days비활성화 백신의 세 번째 접종은 항 SARS-CoV-2 항체의 수준과 붕괴 시간을 극적으로 증가시켰지만 다시 실망스럽게 감소했습니다: 368일 동안 18개의 연속 시점에서 전향적, 종적, 코호트 연구Article Published on 2022-04-292022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] 95% CI activate administration anti-RBD anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody Anti-spike anti-Spike IgG antibody antibody levels booster dose carried conversion rate CoronaVac COVID-19 Day decay dose Efficacy evaluate FIVE fold half-life half-live half-lives IgA IgA level IgG IgM immune immune characteristics immune protection Immunity inactivated Increased Level longitudinal management much lower neutralizing antibody over Point positive positive conversion Predictive predictive values Prospective prospective cohort study regimen regimens remained response revaccination SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 variants second dose subset the SARS-CoV-2 time vaccination Vaccine volunteers [DOI] 10.3389/fimmu.2022.876037 PMC 바로가기 [Article Type] Article
COVID-19 advanced respiratory care educational training programme for healthcare workers in Lesotho: an observational studyObservational Study Published on 2022-04-292022-10-04 Journal: BMJ Open [Category] 임상, [키워드] 95% CI aligned Anatomy approach average basic Care category Conventional COVID-19 COVID-19 pandemic develop evaluate feasible healthcare worker High-flow oxygen implementation infections introduced knowledge low-dose management mechanical ventilation MEDICAL EDUCATION & nasal non-invasive ventilation Nurses oxygen paired t-test participant Participants performance physician Prospective Public public health question respiratory Respiratory care respiratory infections training were used [DOI] 10.1136/bmjopen-2021-058643 PMC 바로가기 [Article Type] Observational Study
Comparison of UK paediatric SARS-CoV-2 admissions across the first and second pandemic waves Research Published on 2022-04-222022-10-05 Journal: Pediatric Research [Category] COVID19(2023년), SARS, 치료제, [키워드] Admission Alpha antibiotic use B.1.1.7 changes in Characteristics children clinical Clinical characteristics co-morbidity Cohort Comorbidity Critical care died disease severity Evidence First wave had no hospitalised hospitals hypothesised Impact less main analysis MIS-C multicentre no evidence of Observational cohort study pandemic Patient proportion Prospective reported Respiratory Support Result SAGE SARS-CoV-2 SARS-COV-2 infection score second wave severity of COVID-19 shielding Support symptomatic those with MIS-C Treatment vaccination variant were excluded [DOI] 10.1038/s41390-022-02052-5 [Article Type] Research
Immune Response to Third Dose BNT162b2 COVID-19 Vaccine Among Kidney Transplant Recipients-A Prospective Study신장 이식 환자의 3차 접종 BNT162b2 COVID-19 백신에 대한 면역 반응-전향적 연구Article Published on 2022-04-212022-09-12 Journal: Transplant International [Category] COVID19(2023년), SARS, 진단, [키워드] 95% confidence interval anti-spike antibody antibody Antibody Response BNT162b2 cellular cellular response conducted control group controls COVID-19 COVID-19 vaccine Cutoff demonstrated dose evaluate evaluated healthcare humoral identify immune response Immunosuppression immunosuppression reduction kidney transplant recipient kidney transplant recipients kidney transplant recipients. log mRNA vaccine Multivariate analysis Odds ratio Participants Primary outcome Prospective Prospective Study reduction remained response Result SARS-CoV-2 second dose seronegative subset T-cell Response Transplant vaccination Vaccine vaccine dose variable [DOI] 10.3389/ti.2022.10204 PMC 바로가기 [Article Type] Article
Factors Associated with Change in SARS-CoV-2 Antibody Titers from Three to Six Months after the Administration of the BNT162b2 mRNA COVID-19 Vaccine among Healthcare Workers in Japan: A Prospective Study일본 의료 종사자의 BNT162b2 mRNA COVID-19 백신 투여 후 3개월에서 6개월 사이의 SARS-CoV-2 항체가 변화와 관련된 요인: 전향적 연구Article Published on 2022-04-152022-09-12 Journal: Internal medicine (Tokyo, Japan) [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome administration age all subject all subjects analyzed Antibody titer BNT162b2 mRNA BNT162b2 vaccine booster change coronavirus COVID-19 COVID-19 vaccine declining decrease dose evaluated Factor healthcare healthcare worker Healthcare workers individual Japan Logistic regression analysis Month objective Older Prospective Result SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 antibody titer titer vaccine administration worker [DOI] 10.2169/internalmedicine.8902-21 PMC 바로가기 [Article Type] Article
Persistent Symptoms in Adult Patients 1 Year After Coronavirus Disease 2019 (COVID-19): A Prospective Cohort Study코로나바이러스 감염증 2019(COVID-19) 1년 후 성인 환자의 지속적인 증상: 전향적 코호트 연구Article Published on 2022-04-092022-09-12 Journal: Clinical Infectious Diseases: An Official Publicat [Category] COVID19(2023년), SARS, 진단, [키워드] acute COVID-19 acute respiratory syndrome ANA titers Analysis analyzed antibody Autoimmunity cofactor cohort of patient Concentration coronavirus coronavirus disease Coronavirus disease 2019 (COVID-19) Course COVID COVID-19 symptom defined Dyspnea elevations etiology Exercise capacity fatigue females follow-up study Frequency Hospitalized Infection laboratory parameter life quality Long Long COVID long-COVID males mental life neurocognitive not differ Patient persistence persistent physical problem Prospective Quality of life reduce reduced SARS-CoV-2 SARS-CoV-2 antibody significantly significantly higher significantly more Symptom symptom onset Symptoms with COVID-19 without symptoms Year [DOI] 10.1093/cid/ciab611 PMC 바로가기 [Article Type] Article
Effect of restrictions imposed due to COVID-19 pandemic on the antenatal care and pregnancy outcomes: a prospective observational study from rural North IndiaObservational Study Published on 2022-04-062022-10-04 Journal: BMJ Open [Category] 임상, [키워드] antenatal care Asymptomatic benefit COVID-19 COVID-19 infection COVID-19 pandemic Effect Epidemiology Government Health implementation incidence India lockdown maternal medicine MOST North offered outcome outcomes Pregnancy pregnant women Preterm birth Primary outcome Prospective prospective observational study protocol public health Registered Safe Satisfaction secondary outcome seeking setting Telemedicine women [DOI] 10.1136/bmjopen-2021-059701 PMC 바로가기 [Article Type] Observational Study
Retinal Findings of Hospitalized Neonates Recovered from COVID-19 Infection: A Prospective, Observational, Descriptive StudyObservational Study Published on 2022-04-052022-10-04 Journal: Journal of tropical pediatrics [Category] COVID19(2023년), SARS, 임상, [키워드] acute respiratory syndrome age alteration caused change Complication coronavirus Coronavirus disease 2019 COVID-19 COVID-19 infection duration of hospitalization Effect evaluated female Hospitalization indirect ophthalmoscopy initial male multiple tissue Neonatal Neonate Neonates ocular organs Patient performed Prospective recovered reported Retina retinal damage Retinal Finding retinal findings. the mean [DOI] 10.1093/tropej/fmac036 PMC 바로가기 [Article Type] Observational Study
Euthyroid sick syndrome as an early surrogate marker of poor outcome in mild SARS-CoV-2 disease경증 SARS-CoV-2 질병에서 좋지 않은 결과의 조기 대리 표지자로서의 유갑상선 질환 증후군Article Published on 2022-04-012022-09-11 Journal: Journal of Endocrinological Investigation [Category] 바이오마커, [키워드] 95%CI analyses biochemical marker biochemical markers Biomarker Complete coronavirus correlated COVID-19 COVID-19 patient COVID-19 patients Cox regression Critical death died disease disorder early stage eligible eligible patient Eligible patients ESS euthyroid sick Euthyroid sick syndrome Evidence framework help Hospital admission Hospitalization Hospitalized ICU identify IL-6 increased risk Infection intensive care intensive care unit Kaplan-Meier Level Low fT3 marker medication Mild mild COVID-19 patients Mild disease Mild SARS-CoV-2 disease. New coronavirus outcome outcomes Patient patients Prognostic markers Prospective Prospective Study required SARS-CoV-2 disease screened sensitivity sick significantly lower specificity syndrome threshold Thyroid thyroid disease thyroid function transfer triiodothyronine were excluded with mild disease [DOI] 10.1007/s40618-021-01714-1 PMC 바로가기 [Article Type] Article
Convalescent plasma treatment in severely immunosuppressed patients hospitalized with COVID-19: an observational study of 28 casesObservational Study Published on 2022-04-012022-10-04 Journal: Infectious diseases (London, England) [Category] Coronavirus, COVID19(2023년), SARS, 임상, [키워드] acute respiratory syndrome antibodies case sery cause CCP clinically convalescent convalescent plasma convalescent plasma treatment coronavirus COVID-19 COVID-19 infection decrease defined died Efficacy heterogeneous group Hospitalized hospitalized patient Immunocompromised patients immunosuppressed patient Immunosuppression In-hospital lymphoma pandemic Patient patients patients hospitalized PCR performed plasma Prospective randomized trial retrospective rituximab SARS-CoV-2 severe immunosuppression Severe infection standard treatment Study design symptom duration treated Treatment Treatment outcome Viremia Virological [DOI] 10.1080/23744235.2021.2013528 PMC 바로가기 [Article Type] Observational Study