Ayurveda botanicals in COVID-19 management: An in silico multi-target approachCovid-19 관리의 Ayurveda 식물 : In In Silico Multi-Target 접근Research Article Published on 2021-06-112022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 치료제, [키워드] adjuvant Administered Antiviral antiviral activity approach Asparagus Ayurveda caused contagious contagious disease coronavirus coronavirus disease COVID-19 disease docking drug therapy Effects evaluate experimental validation global effort global efforts global pandemic immune pathway immune pathways immunomodulators immunomodulatory in silico in-silico India Interaction life cycle management mass spectrometry modulate network pharmacology predict predicted Predictive protective role Protein racemosus Rasayana RNA RNA dependent RNA polymerase RNA polymerase SARS-CoV-2 SARS-CoV2 specific treatment Spike protein target targets termination the disease the Spike therapeutic therapy UHPLC Vaccine Viral viral life cycle virus was performed [DOI] 10.1371/journal.pone.0248479 PMC 바로가기 [Article Type] Research Article
Pneumatosis Intestinalis in the Setting of COVID-19: A Single Center Case Series From New YorkMedicine Published on 2021-06-042022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] acute respiratory syndrome association case sery center coronavirus CoV COVID-19 COVID-19 patient Critically ill patient defined disease epithelial Hospital admission IL-6 IL-6 inhibitor Injury intestinal intestinal wall Ischemia ischemia-reperfusion injury knowledge mesenteric ischemia molecular targeted therapy New York Pathogenesis Patient pneumatosis pneumatosis intestinalis protective role risk SARS-CoV-2 Sery setting single center synergistic TCZ Tocilizumab tocilizumab therapy treatment for COVID-19 [DOI] 10.3389/fmed.2021.638075 PMC 바로가기 [Article Type] Medicine
Demographic, psychological, chronobiological, and work-related predictors of sleep disturbances during the COVID-19 lockdown in ItalyArticle Published on 2021-06-012022-10-29 Journal: Scientific Reports [Category] COVID-19, MERS, SARS, [키워드] advanced age Anxiety caused change Circadian rhythms and sleep collected confinement period Contagion COVID-19 COVID-19 pandemic demographic Depression evaluated Factor female gender healthcare worker individual information Insomnia Italian Italy less lockdown majority measure pandemic Perceived stress predictor predisposition Prevalence protective role Psychological Psychological problems Psychology Questionnaires reduced Regression model reported sleep disorder Sleep disturbance sleep quality Stress Stress and resilience Symptoms [DOI] 10.1038/s41598-021-90993-y PMC 바로가기 [Article Type] Article
Scientific Hypothesis for Treatment of COVID-19’s Lung Lesions by Adjusting ACE/ACE2 ImbalanceACE/ACE2 불균형을 조정하여 COVID-19의 폐 병변 치료를 위한 과학적 가설Article Published on 2021-06-012022-09-11 Journal: Cardiovascular toxicology [Category] SARS, 치료제, [키워드] ACE ACE-2 Adjusting angiotensin approach Cardiovascular function caused clinical trials coronavirus SARS-CoV-2 country COVID-19 COVID-19 infection deaths effective vaccine Effective vaccines entry receptor global pandemic Imbalance knowledge lesion modulating new coronavirus SARS-CoV-2 occurred pharmacological Prevent preventive measure preventive measures protective role Protein RAS Regulation Renin respiratory tract SARS-CoV-2 SARS-COV-2 infection Spread Stage stages treat Variation variations viral infection virus Wuhan Wuhan, China [DOI] 10.1007/s12012-021-09649-y PMC 바로가기 [Article Type] Article
The association between micronutrient and hemogram values and prognostic factors in COVID-19 patients: A single-center experience from TurkeyObservational Study Published on 2021-06-012022-10-05 Journal: International journal of clinical practice [Category] SARS, 임상, [키워드] addition advanced age age Anemia anti-inflammatory effect antioxidant effect approach association Chronic diseases city comorbid disease Complete Concentration correlated COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients dead patients deficiencies demonstrated diagnosed with COVID-19 died disease evaluated examined excessive use folate Follow-up Gender hemoglobin hospital Hospital stay Hospitalization hypertension ICU ICU admission immune system immunomodulatory intensive care unit Intubated iron Leukocytosis lymphocyte lymphocyte counts male material men Micronutrient micronutrients multivitamin supplementation parameter Patient poor prognosis Prognostic factor Prognostic factors protective role provided respiratory tract infection retrospective significantly higher single-center the disease the mean the patient Turkey vitamin B12 vitamin D deficiency vitamin D level White blood cell worse prognosis [DOI] 10.1111/ijcp.14078 PMC 바로가기 [Article Type] Observational Study
The role of unconventional T cells in COVID-19Review Article Published on 2021-05-292022-10-30 Journal: Irish Journal of Medical Science [Category] COVID-19, COVID19(2023년), SARS, [키워드] Γδ T cells acute respiratory syndrome Anti-viral immunity Cancer caused Cell coronavirus COVID-19 disease effective vaccine help human SARS-CoV-2 immune response Immunotherapy Infection iNKT INKT cells MAIT cells mechanism mortality rate mucosal natural killer Pathogenesis protective role Respiratory disease SARS-CoV SARS-CoV-2 SARS-COV-2 infection Severe case shown T cell T cell subset T cells T lymphocytes therapeutic agent these cell Treatment strategies Unconventional T cells viral replication virion virus worldwide pandemic [DOI] 10.1007/s11845-021-02653-9 PMC 바로가기 [Article Type] Review Article
Glycosylation is a key in SARS-CoV-2 infection당화는 SARS-CoV-2 감염의 핵심입니다Review Published on 2021-05-222022-09-12 Journal: Journal of Molecular Medicine (Berlin, Germany) [Category] MERS, SARS, 진단, [키워드] acting Adaptive immune response binding Blood group antigen cascade cause contribute COVID-19 cytokine disease epitope Epitopes Evidence Factor glycan glycans glycosylated glycosylation highlight host cell host cells IgG immune evasion Impact Infection innate and adaptive immune response monoclonal monoclonal antibody pandemic protective role Receptor-binding domain responsible S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike glycoprotein SARS-CoV-2 spike protein Serological testing shown spike glycoprotein Spike protein subsequent syndrome target cell target cells the receptor-binding domain the SARS-CoV-2 Therapeutic strategies therapeutic strategy therapy vaccination Vaccines virus [DOI] 10.1007/s00109-021-02092-0 PMC 바로가기 [Article Type] Review
Human Surfactant Protein D Binds Spike Protein and Acts as an Entry Inhibitor of SARS-CoV-2 Pseudotyped Viral ParticlesImmunology Published on 2021-05-142022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] 16HBE Act acute respiratory syndrome angiotensin converting enzyme 2 animal models bind binding cells composed coronavirus CRD enzyme epithelial Ex vivo expressing hACE2 HCoV-229E HEK293T cell highlight Human human pulmonary collectins immune in vitro in vivo influenza A inhibited inhibitor innate immune Innate immunity Interaction mucosal surface overexpressing Particle Pathogens previous study protective role pseudotyped lentiviral particle Receptor binding domain reduction in reported respiratory RLU S1 protein SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S1 serum spike spike glycoprotein Spike protein suggested surfactant Surfactant protein D Surveillance the patient therapeutic potential Treatment viral entry viral pathogen [DOI] 10.3389/fimmu.2021.641360 PMC 바로가기 [Article Type] Immunology
Tenofovir, Another Inexpensive, Well-Known and Widely Available Old Drug Repurposed for SARS-COV-2 InfectionReview Published on 2021-05-112022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] acute respiratory syndrome Antiretroviral therapy antiviral activity antiviral medication approved ART clinical trials Comorbidity Complete coronavirus Coronavirus infection COVID-19 COVID-19 treatment Critical case different clinical manifestations drug effective Effectiveness Efficacy Evidence explain high risk HIV HIV infection HIV treatment HIV-infected people Human immunodeficiency virus Infection information inhibitor lack MERS-CoV Middle East morbidity Mortality nucleoside/nucleotide analogues nucleotide nucleotide SARS-CoV-2 pandemic previous study progression Prophylaxis protease protective role Remdesivir risk RNA virus RNA-dependent RNA polymerase inhibitors safety profile SARS-CoV SARS-CoV-2 SARS-COV-2 infection severe COVID-19 severity syndrome tenofovir treat virus was tested [DOI] 10.3390/ph14050454 PMC 바로가기 [Article Type] Review
Stress, Anxiety, and Depression for Chinese Residents in Japan during the COVID-19 PandemicArticle Published on 2021-05-072022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] affected Anxiety checklist China Chinese conducted coronavirus disease COVID-19 COVID-19 pandemic COVID-19 symptoms Depression Depressive symptoms disaster Disaster preparedness Effect foreign residents identify Japan knowledge Linear regression mental health offer pandemic Participants Population positive promote protective role psychological symptom psychological symptoms Psychological well-being Rate reducing reported Research resident risk factor scale Social support Stress Stress Scale Support unique were used [DOI] 10.3390/ijerph18094958 PMC 바로가기 [Article Type] Article