Remdesivir in the treatment of coronavirus disease 2019 (COVID-19): a simplified summary코로나바이러스 질병 2019(COVID-19) 치료에 사용되는 렘데시비르: 간략한 요약Article Published on 2021-07-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] 치료제, [키워드] clinical trials conducted contagious coronavirus coronavirus disease coronavirus disease-2019 COVID-19 COVID-19 pandemic decrease Diseases drug illness molecular Mortality Novel coronavirus overlapping pandemic pandemic of COVID-19 Protein target Remdesivir Respiratory illness risk SARS-CoV-2 seasonality summer Treatment treatment of COVID-19 [DOI] 10.1080/07391102.2020.1767691 PMC 바로가기 [Article Type] Article
Pan-ancestry exome-wide association analyses of COVID-19 outcomes in 586,157 individuals586,157명의 COVID-19 결과에 대한 범가계 엑솜 전체 연관성 분석Article Published on 2021-07-012022-09-11 Journal: American Journal of Human Genetics [Category] SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Analysis association browser burden cause center coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 Host Genetics Initiative death Deleterious detectable effect size Exome exome sequencing Genetic variant genetics Hospitalization identify individual individuals initiative interferon pathway multiple testing outcome rare variant Rare variants rare variants. Regeneron reported Respiratory illness Result sample sizes SARS-CoV-2 sequence Seven Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 severe COVID-19 susceptibility loci therapeutic potential TLR7 variant with COVID-19 ZC3HAV1 [DOI] 10.1016/j.ajhg.2021.05.017 PMC 바로가기 [Article Type] Article
COVID-19 and dysnatremia: A comparison between COVID-19 and non-COVID-19 respiratory illnessOriginal Research Article Published on 2021-06-302022-10-28 Journal: SAGE Open Medicine [Category] COVID-19, [키워드] Admission calculated Correcting COVID-19 COVID-19 patient COVID-19 patients Deceased determine disorder Dysnatremia fluctuation hospitalized COVID-19 patient hypernatremia hyponatremia implication mortality rate Non-COVID-19 Non-COVID-19 patients Occurrence P -value Patient patients plasma polymerase chain Respiratory illness retrospective SARS Coronavirus SARS-CoV-2 significantly more sodium sodium balance sodium concentration statistical significance Treatment was obtained was used [DOI] 10.1177/20503121211027778 PMC 바로가기 [Article Type] Original Research Article
Manipulation of the unfolded protein response: A pharmacological strategy against coronavirus infection전개된 단백질 반응의 조작: 코로나바이러스 감염에 대한 약리학적 전략Research Article Published on 2021-06-172022-09-10 Journal: PLoS Pathogens [Category] 진단, 치료제, [키워드] activate activated Activation antiviral target ATF6 Betacoronavirus Betacoronavirus genus Cancer cellular cellular response chronic respiratory disease composed coronavirus Coronavirus infection Coronavirus replication COVID-19 COVID-19 pandemic develop died Diseases drug Endoplasmic reticulum ENhance fold genetic information highlight human lung cells in some induce infected cells Infection inhibited inhibitor manipulation medication MHV Mild mild to moderate moderate Modification MOST murine hepatitis virus neurodegenerative disorder neurodegenerative disorders Novel coronavirus Older ORF8 over-expression pathway pharmacological problem Protein protein levels reduce reduced reducing replicate Replication respiratory Respiratory disease Respiratory illness responsible RNA sequencing S protein S proteins SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2-infected cells significantly the Betacoronavirus the SARS-CoV-2 these compound these compounds These data transcriptional translational Treatment triggered unfolded protein response up-regulated UPR viral disease Viral protein Viral proteins virion virus [DOI] 10.1371/journal.ppat.1009644 PMC 바로가기 [Article Type] Research Article
Seroprevalence of human coronaviruses among patients visiting hospital-based sentinel sites in UgandaResearch Published on 2021-06-162022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, MERS, [키워드] age analyzed antibody circulating coded collected coronavirus coronavirus strain Coronaviruses Cross reactivity described detect emerging viral infections Febrile illnesses FIVE highest homology Human human coronavirus human coronaviruses identify IgG ELISA influenza like illness lowest no significant difference Odds ratio Patient Prevalence prevalent Proteins Qualitative recorded Respiratory illness respiratory infection Result seropositive Seroprevalence serum sample severity subtype Uganda Volunteer [DOI] 10.1186/s12879-021-06258-6 PMC 바로가기 [Article Type] Research
Impact of Social Distancing and Travel Restrictions on Non-Coronavirus Disease 2019 (Non-COVID-19) Respiratory Hospital Admissions in Young Children in Rural AlaskaArticle Published on 2021-06-152023-06-20 Journal: Clinical Infectious Diseases: An Official Publicat [Category] Fulltext, MERS, [키워드] Respiratory illness RSV social distancing Travel restriction [DOI] 10.1093/cid/ciaa1328 PMC 바로가기
COVID‐19 induced bradyarrhythmia and relative bradycardia: An overviewClinical Review Published on 2021-06-142022-10-31 Journal: Journal of Arrhythmia [Category] COVID-19, [키워드] acute coronary syndromes Affect Algorithm Arrhythmias arrythmia bradyarrhythmia bradycardia Cardiomyopathies cardiovascular disease cardiovascular system clinician Coagulopathy Community coronavirus COVID‐19 COVID‐19 described Epidemiology incidence increase in increased risk infected patient infected patients literature review management mechanism medication side effect Mortality multifactorial myocarditis novel coronavirus 2019 organ Pathogenesis Patient Prognostic value Respiratory illness shown Treatment virus while [DOI] 10.1002/joa3.12578 PMC 바로가기 [Article Type] Clinical Review
Assessing Knowledge and Practices of the Community towards Corona Virus Disease 2019 in Mbale Municipality, Uganda: Across Section StudyOriginal Article Published on 2021-06-112022-10-31 Journal: The East African Health Research Journal [Category] COVID-19, [키워드] activity Assessing carried caused chills China Community Corona Corona virus COVID 19 COVID-19 cross Culture difficulty in breathing disease dry cough education effective Face masks Facebook facemask female Fever function group headache Health Health education material health worker highest information knowledge male measure media Ministry of Health moderate MOST municipality Muslim novel observation observé Pain participant Practice respiratory Respiratory illness risk Section shaking Shortness of breath social media platform sore throat the disease Uganda was obtained Wuhan [DOI] 10.24248/eahrj.v5i1.647 PMC 바로가기 [Article Type] Original Article
Demographic, multi-morbidity and genetic impact on myocardial involvement and its recovery from COVID-19: protocol design of COVID-HEART—a UK, multicentre, observational studyCOVID-19로부터 심근 침범 및 회복에 대한 인구통계학적, 다중 이환율 및 유전적 영향: COVID-HEART의 프로토콜 설계 - 영국, 다기관, 관찰 연구Study Protocol Published on 2021-06-102022-09-10 Journal: Journal of Cardiovascular Magnetic Resonance [Category] MERS, SARS, 바이오마커, 임상, [키워드] 6MWT adenosine adverse outcomes age assessment assessments Baseline assessment cardiovascular disease Cardiovascular Magnetic Resonance characterisation clinical Clinical outcome Clinical significance Comorbidities Comorbidity coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient demographic demographics dependent on discharged ECG electrocardiogram elevated Ethnicity evaluate Factors functional functional capacity gadolinium Genetic genetic factors genetics In-hospital include increasingly ISRCTN life longitudinal cohort study measure Mortality multicentre Myocardial Myocardial infarction Myocardial inflammation myocardial injury myocardial involvement Myocardial repair myocarditis Myopericarditis pathophysiology Patient patients protocol Quality of life reported respiratory Respiratory illness risk factor selected serum biomarker serum biomarkers Sex Stress T1/T2 troponin [DOI] 10.1186/s12968-021-00752-1 PMC 바로가기 [Article Type] Study Protocol
Prospective Assessment of SARS-CoV-2 Seroconversion (PASS) study: an observational cohort study of SARS-CoV-2 infection and vaccination in healthcare workersSARS-COV-2 SEROCONVERSION (PASS) 연구의 전향 적 평가 : 의료 근로자의 SARS-COV-2 감염 및 예방 접종에 대한 관찰 코호트 연구Study Protocol Published on 2021-06-092022-09-01 Journal: BMC Infectious Diseases [Category] MERS, SARS, 진단, [키워드] Affect Analysis Anti-spike antibody assessment Asymptomatic baseline clinical response Cohort Complete conducted coronavirus coronavirus disease Coronavirus disease 2019 CoV covariates COVID-19 COVID-19 disease COVID-19 disease course cross-reactivity cytokine production determine develop disease symptoms evaluate Frequency glycoprotein HCoV HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 HCoVs HCWs healthcare healthcare worker HKU1 human coronavirus IgG antibodies IgM and IgG immune response immune responses Immune-response immunological individual Infection intensity Killer cell magnitude mononuclear cell natural natural killer cell NL63 number of infected Observational cohort study OC43 pandemic coronavirus participant pauci-symptomatic PBMCs peptide peptide pool performed Peripheral blood Peripheral blood mononuclear cells positive Prospective Prospective Study questionnaire receive respiratory Respiratory disease Respiratory illness SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 PCR SARS-CoV-2 PCR testing SARS-CoV-2 vaccination SARS-CoV-2 vaccine seroconvert serology analysis severe respiratory illness severity Spike proteins supplementary material Symptom T cell T cell activation T cell response T cell responses tested the SARS-CoV-2 the spike protein vaccination Vaccine viral respiratory with COVID-19 [DOI] 10.1186/s12879-021-06233-1 PMC 바로가기 [Article Type] Study Protocol