Disentangling conflicting evidence on DPP-4 inhibitors and outcomes of COVID-19: narrative review and meta-analysisDPP-4 억제제 및 COVID-19의 결과에 대한 상충되는 증거 풀기: 내러티브 검토 및 메타 분석Meta-Analysis Published on 2021-07-012022-09-11 Journal: Journal of Endocrinological Investigation [Category] SARS, 바이오마커, [키워드] 95% CI absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adverse outcome association Cell conducted coronavirus coronavirus disease Coronavirus disease-19 COVID-19 diabetes Diabetes Mellitus dipeptidyl peptidase Dipeptidyl peptidase-4 DPP4 Epidemiology Evidence immune system Inconclusive increase Incretins independent risk factor Infection inhibitor Meta-analysis Mortality mortality rate Neutral no effect observational studies observational study outcome outcomes pandemic Patient provide Randomized controlled trials Regulation reported Research respiratory respiratory tract risk risk ratio SARS-CoV-2 severe acute respiratory syndrome Coronavirus shown significantly lower Spread suggested systematic review Topic Treatment while [DOI] 10.1007/s40618-021-01515-6 PMC 바로가기 [Article Type] Meta-Analysis
Ivermectin and mortality in patients with COVID-19: A systematic review, meta-analysis, and meta-regression of randomized controlled trials코로나19 환자의 이버멕틴과 사망률: 무작위 대조 시험의 체계적인 검토, 메타 분석 및 메타 회귀Meta-Analysis Published on 2021-07-012022-09-11 Journal: Diabetes & metabolic syndrome [Category] SARS, 신약개발, 임상, [키워드] age Analysis benefit certainty of evidence ClinicalTrials control group coronavirus COVID-19 database databases decreased mortality diabete diabetes double-blinded hypertension inception intervention group Ivermectin Meta-analysis meta-regression Mortality Patient patients with COVID-19 Placebo placebo-controlled Primary outcome Randomized controlled trial RCT RCTs reduction reported required risk risk ratio SARS-CoV-2 sensitivity analysis severe COVID-19 Sex Standard of care statistical significance subgroup analysis systematic literature search systematic review therapy was performed was reduced [DOI] 10.1016/j.dsx.2021.102186 PMC 바로가기 [Article Type] Meta-Analysis
Ivermectin for Prevention and Treatment of COVID-19 Infection: A Systematic Review, Meta-analysis, and Trial Sequential Analysis to Inform Clinical GuidelinesCOVID-19 감염 예방 및 치료를 위한 Ivermectin: 임상 지침을 제공하기 위한 체계적인 검토, 메타 분석 및 시험 순차 분석Meta-Analysis Published on 2021-06-212022-09-11 Journal: American journal of therapeutics [Category] SARS, 치료제, [키워드] 95% confidence interval adverse event Analysis anti-inflammatory properties antiparasitic Antiviral approach Area average average risk benefit certainty Chemoprophylaxis clinical Clinical course clinical trials conducted COVID-19 COVID-19 infection database death Deterioration Efficacy estimate Evidence evidence of guideline high risk Inclusion Ivermectin ivermectin treatment less mechanical ventilation Medicine meta-analyses Meta-analysis Mortality no difference outcome pandemic participant prevention Prophylaxis provided Randomized controlled trial reduce reduced reduced risk reducing mortality reductions in review Risk of bias risk ratio robust SARS-CoV-2 pandemic SARS-CoV-2 virus searched secondary secondary outcome Secondary outcomes sequential analysis severe adverse events severe disease suggested tested the SARS-CoV-2 the SARS-CoV-2 virus treatment trial treatment trials Trial trial sequential analyses trial sequential analysis [DOI] 10.1097/MJT.0000000000001402 PMC 바로가기 [Article Type] Meta-Analysis
Hydroxychloroquine plus standard of care compared with standard of care alone in COVID-19: a meta-analysis of randomized controlled trialsCOVID-19에서 표준 치료와 비교한 하이드록시클로로퀸과 표준 치료: 무작위 대조 시험의 메타 분석Meta-Analysis Published on 2021-06-072022-09-10 Journal: Scientific Reports [Category] SARS, 임상, 치료법, 치료제, [키워드] 95% CI 95% confidence interval addition adverse event adverse events all-cause mortality benefit body temperature Chain Reaction clinical clinical trials Cochrane Library collaboration controlled trials coronavirus coronavirus disease COVID-19 database Disease progression Efficacy and safety eligible evaluated HCQ Hospital stay hospitalized patient hospitalized patients Hydroxychloroquine identify mechanical ventilation Medical research medRxiv Meta-analysis no significant differences Outcomes research Patient PCR polymerase chain polymerase chain reaction Randomized controlled trial Recovery time resources risk ratio searched significant difference significant differences Standard of care systematic review Treatment treatment group two group two groups Version was performed Web with COVID-19 [DOI] 10.1038/s41598-021-91089-3 PMC 바로가기 [Article Type] Meta-Analysis
Decreased Mortality in Coronavirus Disease 2019 Patients Treated With Tocilizumab: A Rapid Systematic Review and Meta-analysis of Observational StudiesTocilizumab으로 치료받은 코로나바이러스 질병 2019 환자의 사망률 감소: 관찰 연구의 신속한 체계적 검토 및 메타 분석Meta-Analysis Published on 2021-06-012022-09-12 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 진단, [키워드] 95% CI 95% confidence interval antagonist Cochrane Library control group coronavirus disease COVID-19 COVID-19 patient death Decreased Effect favor IL-6 IL-6 receptor IL-6 receptor antagonists increased risk index lower mortality Meta-analysis Mortality no difference Patient PMC prevented PubMed Central Randomized controlled trials Rapid receptor reduce mortality Research retrieved review risk risk ratio searched Side effect Side effects TCZ therapy Tocilizumab treat treated unique was used Web of Science World Health Organization [DOI] 10.1093/cid/ciaa1445 PMC 바로가기 [Article Type] Meta-Analysis
The efficacy and safety of Favipiravir in treatment of COVID-19: a systematic review and meta-analysis of clinical trialsCOVID-19 치료에서 Favipiravir의 효능 및 안전성: 임상 시험의 체계적인 검토 및 메타 분석Meta-Analysis Published on 2021-05-262022-09-10 Journal: Scientific Reports [Category] SARS, 신약개발, 임상, 치료법, 치료제, [키워드] addressed adverse event adverse events Analysis Antiviral approved calculated clearance Clinical improvement clinical setting clinical trial collaboration Comprehensive control group COVID-19 patient criteria database drug Efficacy Efficacy and safety Egger explain Favipiravir Hospitalization ICU Infection Infectious diseases less Meta-analysis Mild mild to moderate Mild to moderate COVID-19 Moderate COVID-19 Mortality mortality rate not significant Novel coronavirus outbreak oxygen Oxygen therapy Patient performed PROSPERO protocol public health systems publication bias Registered reported risk risk of bia risk ratio SARS-CoV2 searched Seven Spread statistically statistically significant Supplemental oxygen therapy Symptom systematic review term tested the patient Treatment two groups Viral viral clearance viral infection was used Web [DOI] 10.1038/s41598-021-90551-6 PMC 바로가기 [Article Type] Meta-Analysis
Vitamin D supplementation for the treatment of COVID-19: a living systematic reviewCOVID-19 치료를 위한 비타민 D 보충: 살아있는 체계적인 검토Article Published on 2021-05-242022-09-11 Journal: The Cochrane database of systematic reviews [Category] 임상, [키워드] 95% CI 95% confidence interval acute respiratory syndrome addressed Administered adverse event adverse events age all-cause mortality approach Arm Asymptomatic Asymptomatic disease baseline benefit Blood level blood levels calcifediol certainty certainty of evidence cholecalciferol clinical clinical status Cochrane COVID-19 Study Register comparability Consistency control group control groups coronavirus disease coronavirus diseases COVID-19 COVID-19 symptoms daily dose Data collection death decrease described determine died disease disease severity dose effective Effectiveness Effects Ethnicity event Evidence excluded Gender Health Organization heterogeneity High dose higher risk hospital discharge hypercalcaemia identify include indicate individual individuals inflammatory markers information Invasive mechanical ventilation investigated life maintain MERS methodological methodology Middle East Middle East respiratory syndrome Mild Mild disease moderate moderate or severe disease moderate to severe Mortality multiple dose multiple doses nine oral calcifediol oral cholecalciferol outcome outcomes participant Participants people with COVID-19 Placebo placebo group placebo treatment Population progression Quality Quality of life randomisation randomised controlled trial Randomised controlled trials RCT RCTs recording reported required risk of bia risk ratio Safe Safety searched Selection selective Serious Adverse Event Serious Adverse Events Severe acute respiratory syndrome severe disease Standard of care subject syndrome systematic review the placebo group the WHO treated Treatment treatment for COVID-19 treatment of COVID-19 viral clearance Vitamin D vitamin D serum Vitamin D status Vitamin D supplementation vomiting Web of Science WHO World Health Organization [DOI] 10.1002/14651858.CD015043 PMC 바로가기 [Article Type] Article
Differential impact of non-pharmaceutical public health interventions on COVID-19 epidemics in the United StatesResearch Article Published on 2021-05-212022-10-28 Journal: BMC Public Health [Category] COVID-19, SARS, [키워드] 95% CI adopted approach assist Combination conducted contributed country COVID-19 COVID-19 epidemic Critical Diseases effective Effectiveness Epidemic epidemic control Epidemics Generalized linear model GLM Government Health Impact initial Intervention Mask measurement mitigate nine Non-pharmaceutical public health interventions novel coronavirus disease NPI NPIs pandemic Public health intervention Quantitative reduction in reported Reproduction number Result retrospective risk ratio RRs shown supplementary material the epidemic the United State The United States Travel widespread [DOI] 10.1186/s12889-021-10950-2 PMC 바로가기 [Article Type] Research Article
Implementation of different HIV self-testing models with implications for HIV testing services during the COVID-19 pandemic: study protocol for secondary data analysis of the STAR Initiative in South AfricaHIV/AIDS Published on 2021-05-182022-10-28 Journal: BMJ Open [Category] Coronavirus, Fulltext, SARS, [키워드] 95% CI analysed Analysis approach approved Care collected COVID-19 Data analysis Descriptive statistics determine dissemination distribution Ethics ethics committee evaluate Factor health authorities Health policy help HIV HIV & AIDS HIV testing Human identify implication include initiative International international health services Local maintain outcome performed Poisson regression populations Prevent Prospective Study protocol reactive reported risk ratio robust social distancing Sociodemographic factor South Africa spread of COVID-19 STAR Study protocol Treatment university variable Wit [DOI] 10.1136/bmjopen-2020-048585 PMC 바로가기 [Article Type] HIV/AIDS
Randomized controlled trial of convalescent plasma therapy against standard therapy in patients with severe COVID-19 disease중증 COVID-19 질환 환자의 표준 요법에 대한 회복기 혈장 요법의 무작위 대조 시험Randomized Controlled Trial Published on 2021-05-112022-08-13 Journal: Scientific Reports [Category] SARS, 임상, 치료기술, 치료법, [키워드] 95% CI appear biochemical parameter Biochemical parameters clinical Clinical outcome confirmation Control Controlled trial convalescent patient Convalescent plasma therapy COVID-19 disease COVID-19 patient CP group died feasibility ferritin ferritin level higher risk hospitalized COVID-19 patient hospitalized COVID-19 patients hypoxia IMPROVE measure mechanical ventilation Mortality NIV no difference no differences no significant difference no significant differences Non-invasive not differ one patient open open label Patient pilot study plasma Primary outcome primary outcome measure Randomized Randomized controlled trials required respiratory indice respiratory indices risk risk ratio Safe secondary outcome secondary outcome measure Secondary outcomes severe COVID-19 severe COVID-19 disease severe disease Standard of care Standard therapy therapy Trial Two patient two patients Ventilation Virology [DOI] 10.1038/s41598-021-89444-5 PMC 바로가기 [Article Type] Randomized Controlled Trial