Response to three doses of the Pfizer/BioNTech BNT162b2 COVID-19 vaccine: a retrospective study of a cohort of haemodialysis patients in France화이자/바이오엔텍 BNT162b2 코로나19 백신 3회 투여에 대한 반응: 프랑스 혈액투석 환자 집단에 대한 후향적 연구Observational Study Published on 2022-05-182022-09-12 Journal: BMC Nephrology [Category] COVID19(2023년), MERS, SARS, 임상, 진단, [키워드] Anti-spike blood sample BNT162b2 body mass index booster Clinical practice Cohort Comirnaty coronavirus disease COVID-19 defined dialysis dose Factor France French Haemodialysis humoral humoral immune response identify IgG Immunoglobulin injection Injections kidney mortality rate mRNA vaccine National non-responder of BNT162b2 Patient patients performed Pfizer/BioNTech receive Registered remained Responder response retrospective Retrospective study SARS-CoV-2 serological serum albumin significantly significantly higher study population the mean the median titre U/mL Vaccine vaccine doses venous [DOI] 10.1186/s12882-022-02751-5 PMC 바로가기 [Article Type] Observational Study
Analyzing inherent biases in SARS-CoV-2 PCR and serological epidemiologic metricsSARS-CoV-2 PCR 및 혈청학적 역학적 지표에 내재된 편향 분석Observational Study Published on 2022-05-132022-09-11 Journal: BMC Infectious Diseases [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody Antibody detection basic reproduction number bias caution Chain Reaction clearance conducted coronavirus Course cross-sectional survey Cross-sectional surveys detectable develop diagnose Effect Epidemic epidemic peak Epidemics epidemiological estimation incidence Infection Inference inherent biase investigated mathematical mathematical model Measures Metrics MONITOR Observational data outcome PCR PCR positivity PCR testing polymerase chain polymerase chain reaction populations positive predicted Prevalence progression Prospective respiratory SARS-CoV-2 SARS-CoV-2 PCR serological Serological testing Seroprevalence severe acute respiratory syndrome Coronavirus tested [DOI] 10.1186/s12879-022-07425-z PMC 바로가기 [Article Type] Observational Study
A simple reverse genetics method to generate recombinant coronaviruses재조합 코로나바이러스를 생성하는 간단한 역유전학 방법Article Published on 2022-05-042022-09-11 Journal: EMBO Reports [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] accelerate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 advance Antiviral assays antivirals biological property Biology cDNA Characteristics Complete coronavirus coronavirus genome coronavirus genomes Diagnosis effective Engineering facilitate fluorescent generate genetics genomic genomic variant genomic variants in vivo in vivo experiment in vivo experiments molecular Mutation Pathogens reagents reconstruction reporter reporter strain reverse genetics SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 variants serological serology severe acute respiratory syndrome Coronavirus simplicity Specific specific mutations Strains the SARS-CoV-2 the SARS-CoV-2 genome therapeutic variants viral pathogen virus wild-type [DOI] 10.15252/embr.202153820 PMC 바로가기 [Article Type] Article
COVID-19 patient serum less potently inhibits ACE2-RBD binding for various SARS-CoV-2 RBD mutantsCOVID-19 환자 혈청은 다양한 SARS-CoV-2 RBD 돌연변이에 대한 ACE2-RBD 결합을 덜 강력하게 억제합니다Article Published on 2022-05-032022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] ACE2 ACE2 binding ACE2 receptor ACE2-RBD ACE2-RBD binding Affect Analysis analyzed antibody bead binding classical correlated COVID-19 patient COVID-19 patient serum disease severity displaying E484K E484K mutation examined extension IgG levels immune protection increasingly Infectious virus inhibit Interaction less Longevity mimicking multiplex Multiplex assay mutant NAbs neutralization test neutralization tests Neutralizing activity Neutralizing antibodies positively correlated proceed protective immunity RBD RBDs Receptor binding domain reduced SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 variant SARS-CoV-2 variants serological serum sample serum samples severity the RBD therapy vaccination variant variants variants of interest virus neutralization test VoC VOCs VOIs was reduced WHO wild-type [DOI] 10.1038/s41598-022-10987-2 PMC 바로가기 [Article Type] Article
Seroprevalence of hepatitis B and C viruses in moderate and severe COVID-19 inpatients: A cross-sectional study at a referral center in Mexico중등도 및 중증 COVID-19 입원 환자에서 B형 및 C형 간염 바이러스의 혈청 유병률: 멕시코의 의뢰 센터에서 단면 연구Article Published on 2022-05-012022-09-12 Journal: Annals of hepatology [Category] B형 간염, COVID19(2023년), MERS, SARS, 진단, [키워드] Anti-HCV antibody Antigen Blood Transfusion Care cause caused coronavirus disease Coverage COVID-19 COVID-19 hospitalization cross-sectional Elimination HBsAg HBV HBV surface antigen HCV Healthcare system help hepatitis B Hepatitis B virus hepatitis C hepatitis C virus hospital laboratory result material medical records moderate Patient performed plan positive Prevalence Protective retrieved Retrospective study risk factor SARS-CoV-2 Screening serological seronegative patients Seroprevalence severe COVID-19 tested undetectable vaccination virus [DOI] 10.1016/j.aohep.2022.100684 PMC 바로가기 [Article Type] Article
Exploratory assessment of serological tests to determine antibody titer against SARS-CoV-2: Appropriateness and limitsSARS-CoV-2에 대한 항체가를 결정하기 위한 혈청학적 검사의 탐색적 평가: 적절성 및 한계Multicenter Study Published on 2022-05-012022-09-11 Journal: Journal of Clinical Laboratory Analysis [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] Analysis analyzed antibody Antibody titer Antibody titers appropriateness can be used Definition detect determine diagnostic diagnostic test diagnostic tests effective Effectiveness Elecsy Elecsys evaluated Health highlight IgA immunoassay Immunoglobulin immunoglobulins Infection International international standard International standards laboratory data limit limitation Luminex xMAP multicenter multiplex Multiplex assay multiplicity RBD resulting Roche S1 domain SARS-CoV-2 SARS-CoV-2 IgG SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 test SARS-CoV-2 tests selected serological serological test Serological tests serum serum sample serum samples Siemen Spike protein Standard subject subjects the SARS-CoV-2 the WHO titer to define vaccination Variability WHO [DOI] 10.1002/jcla.24363 PMC 바로가기 [Article Type] Multicenter Study
Designed SARS-CoV-2 receptor binding domain variants form stable monomers설계된 SARS-CoV-2 수용체 결합 도메인 변이체가 안정적인 단량체를 형성합니다.Article Published on 2022-05-012022-09-11 Journal: Biotechnology Journal [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료제, [키워드] addressed aggregates antibody antibody assay validation Antigen antigen stability binding domain Cell convalescent sera COVID-19 COVID-19 patient cysteine cysteine residue Deletion enzyme enzyme-linked immunosorbent assay enzyme-linked immunosorbent assays eukaryotic systems expression HEK293 homogeneous intrinsic maintenance mammalian cell mammalian cells monomer monomeric Neutralizing antibodies O-glycosylation site produced Protein RBD RBD variant Receptor binding Receptor binding domain Recombinant expression reduce SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 receptor SARS-CoV-2 spike SARS-CoV-2 test sequence serological shown Substitution the SARS-CoV-2 vaccine candidates Vaccine development variant virus-neutralizing antibodies virus-neutralizing antibody [DOI] 10.1002/biot.202100422 PMC 바로가기 [Article Type] Article
A comprehensive assessment of long-term SARS-CoV-2-specific adaptive immune memory in convalescent COVID-19 Solid Organ Transplant recipients회복기 COVID-19 고형장기 이식 수혜자의 장기 SARS-CoV-2 특이 적응 면역 기억에 대한 종합적인 평가Article Published on 2022-05-012022-09-11 Journal: Kidney international [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] adaptive Adaptive immunity Asymptomatic Clinical severity controls convalescent convalescent patient Convalescent patients COVID-19 COVID-19 infection COVID-19 severity cytokine detectable determined by driven by eight ELISA IFN-γ IFN-γ producing T cells IL-2 IL12 immune immune memory individual individuals Infection kidney liver long-lasting lung memory B cell memory B cells memory response Mild organ transplantation Patient performed producing recipient reported response SARS-CoV-2 SARS-COV-2 infection serological seropositive severity significantly Solid solid organ solid organ transplant solid organ transplantation solid organ transplants T cells Transplant transplantation while [DOI] 10.1016/j.kint.2021.12.029 PMC 바로가기 [Article Type] Article
False positive Herpes Simplex IgM serology in COVID-19 patients correlates with SARS-CoV-2 IgM/IgG seropositivityCOVID-19 환자의 위양성 단순 헤르페스 IgM 혈청 검사는 SARS-CoV-2 IgM/IgG 혈청 양성과 상관관계가 있습니다Article Published on 2022-05-012022-09-12 Journal: Diagnostic microbiology and infectious disease [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Adding Adsorption cause caused correlation COVID-19 COVID-19 patient COVID-19 patients diagnosed enzyme-linked immunosorbent False positive Herpe herpes simplex Herpes simplex IgM Heterologous IgM IgM/IgG immunoassay Immunoglobulin immunoglobulins inhibiting Interference Laboratory features molecular non-specific Patient Pneumonia Polyvinylpyrrolidone positive reactive SARS-CoV-2 serological serology Significant simplex tested Viral pneumonia [DOI] 10.1016/j.diagmicrobio.2022.115653 PMC 바로가기 [Article Type] Article
Blood donor serological screening for SARS-CoV-2 as a tool to estimate the prevalence of asymptomatic infection in a low-intermediate endemic area of southern Italy after the first wave of the pandemic대유행의 첫 번째 물결 이후 이탈리아 남부의 중급 풍토병 지역에서 무증상 감염의 유병률을 추정하기 위한 도구로 SARS-CoV-2에 대한 헌혈자 혈청 검사Article Published on 2022-05-012022-09-12 Journal: Blood transfusion = Trasfusione del sangue [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] asymptomatic infection blood donor endemic area First wave Italy pandemic Prevalence SARS-CoV-2 serological [DOI] 10.2450/2021.0196-21 PMC 바로가기 [Article Type] Article