Safety and immunogenicity of an inactivated SARS-CoV-2 vaccine (CoronaVac) in inadvertently vaccinated healthy children실수로 예방 접종을 받은 건강한 어린이에서 비활성화된 SARS-CoV-2 백신(CoronaVac)의 안전성 및 면역원성Article Published on 2021-12-062022-09-12 Journal: Revista do Instituto de Medicina Tropical de São [Category] MERS, SARS, 진단, [키워드] ACE2 receptor binding adverse effects adverse event age Antibody titer binding Brazil children China collected contribute CoronaVac COVID-19 vaccine domain dose Follow-up healthy children IgG immunogenic inactivated increase in Local Mild positive positive serology presenting Protein robust Safe Safety SARS-COV-2 infection SARS-CoV-2 S1 SARS-CoV-2 vaccine serological response serology seronegative serum sample Seven Sinovac state Symptom tested vaccination Vaccine [DOI] 10.1590/S1678-9946202163083 PMC 바로가기 [Article Type] Article
The Humoral Immune Response to BNT162b2 Vaccine Is Associated With Circulating CD19+ B Lymphocytes and the Naïve CD45RA to Memory CD45RO CD4+ T Helper Cells Ratio in Hemodialysis Patients and Kidney Transplant RecipientsImmunology Published on 2021-12-032022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] alteration analyzed anti-SARS-CoV2 antibodies antibody production Antibody Response Antibody titer association B cell B cells B lymphocyte baseline BNT162b2 CD19+ CD19+ B lymphocytes CD4+ CD45RA CD45RO Cellular immune response circulating correlation dose first dose flow cytometry fraction helper Hemodialysis humoral Immunosuppressed in both group in both groups kidney transplant recipient kidney transplant recipients lymphocyte material memory memory CD4+CD45RO+ T helper cells naïve CD4+CD45RA+ T helper cells naïve Patient positive correlation provide Ratio recipient response Result SARS-CoV-2 vaccination SARS-CoV2 second dose seronegative seropositive subpopulation T cell T helper cell Transplant vaccination vaccination efficacy vaccine dose vaccine-induced antibody response [DOI] 10.3389/fimmu.2021.760249 PMC 바로가기 [Article Type] Immunology
COVID-19 mRNA Based Vaccine Immune-Response Assessment in Nursing Home Residents for Public Health DecisionArticle Published on 2021-12-022022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] addressed antibodies antibody approved assessment cellular cellular response cellular-immune response competent complement COVID-19 COVID-19 infection decision Europe Frequency higher risk home humoral immune immune response Infection mRNA mRNA vaccine mRNA-based vaccine Nursing nursing home nursing home residents outcome Public public health resident SARS-CoV-2 seronegative Spain subject T cell the vaccine vaccination Vaccine vaccine response were measured [DOI] 10.3390/vaccines9121429 PMC 바로가기 [Article Type] Article
COVID-19 prevention with subcutaneous administration of the monoclonal antibodies casirivimab and imdevimab: Subgroup analysis in participants with cardiovascular disease and diabetesConference abstract Published on 2021-12-012022-10-05 Journal: American heart journal [Category] 임상, [키워드] 1:1 Administered administration adverse event Analysis Asymptomatic Asymptomatic COVID-19 baseline Baseline serology cardiovascular disease COVID-19 CVD diabete diabetes diagnosed Efficacy Evidence figure headache hypertension Immunity increased risk index case individual monoclonal antibody monoclonal antibody combination participant performed phase Placebo positive post-hoc analysis prevented primary endpoint proportion Randomized reduced REGEN-COV reported Result risk risk reduction RT-qPCR SARS-CoV-2 seronegative severe disease study participant subcutaneously symptomatic infection symptomatic SARS-CoV-2 infection table Treatment Trial [DOI] 10.1016/j.ahj.2021.10.067 [Article Type] Conference abstract
Safety, tolerability, and immunogenicity of an aerosolised adenovirus type-5 vector-based COVID-19 vaccine (Ad5-nCoV) in adults: preliminary report of an open-label and randomised phase 1 clinical trial성인에서 에어로졸화된 아데노바이러스 5형 벡터 기반 COVID-19 백신(Ad5-nCoV)의 안전성, 내약성 및 면역원성: 공개 및 무작위 1상 임상 시험의 예비 보고서Clinical Trial Published on 2021-12-012022-09-12 Journal: The Lancet. Infectious Diseases [Category] Fulltext, SARS, 임상, 진단, [키워드] 95% CI Adenovirus adverse event age allergy anti-SARS-CoV-2 approved assigned booster booster vaccination Booster vaccine caused China Chinese Chronic illness clinical trial common adverse event computer-generated COVID-19 COVID-19 vaccine deaths development dose Efficacy elicited enrolled evaluate evaluated fatigue Fever FIVE five group for inclusion geometric mean concentration geometric mean titre group headache High dose IgG IgG antibody individual initial intramuscular Intramuscular injection intramuscular vaccination Laboratory low dose Major material neutralising antibody Neutralising antibody responses occurred Open-label outcome participant Participants phase 1 trial pregnant women preliminary report primary immunogenicity randomisation randomised Randomly receptor Receptor binding Registered reported Safety SARS-CoV-2 Science screened sequence Serious Adverse Event seronegative stratified by sex technology Tolerability translation Trial vaccination Vaccine Viral particles were excluded Wuhan, China [DOI] 10.1016/S1473-3099(21)00396-0 PMC 바로가기 [Article Type] Clinical Trial
Low risk of reinfections and relation with serological response after recovery from the first wave of COVID-19COVID-19의 첫 번째 물결에서 회복된 후 재감염 위험이 낮고 혈청학적 반응과의 관계Article Published on 2021-12-012022-09-12 Journal: European Journal of Clinical Microbiology & Infect [Category] MERS, SARS, 진단, [키워드] age antibody Asymptomatic collected COVID-19 COVID-19 reinfection female First wave Follow-up healthcare IgG IgM response immunization individuals with COVID-19 IQR Italy longitudinal longitudinal study manifested median median age Mild mild infection observation period occurred Outpatient Patient patients Reinfection risk SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 IgG SARS-CoV-2 IgM SARS-CoV-2 reinfection SARS-CoV-2 serology serological serological response serology seronegative seropositive the disease with COVID-19 [DOI] 10.1007/s10096-021-04335-x PMC 바로가기 [Article Type] Article
Analysis of Serological Biomarkers of SARS-CoV-2 Infection in Convalescent Samples From Severe, Moderate and Mild COVID-19 Cases중증, 중등도 및 경증 COVID-19 사례의 회복기 샘플에서 SARS-CoV-2 감염의 혈청학적 바이오마커 분석Comparative Study Published on 2021-11-192022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, 변종, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome addition antibodies antibody Antibody binding antibody levels Antibody Response Antibody responses Antibody Units Antigen Asymptomatic asymptomatic infection average BAU binding antibodies binding antibody binding antibody units Biomarker Biomarkers candidate Clinical severity convalescent sera correlated correlates of protection COVID-19 COVID-19 disease COVID-19 immune response COVID-19 pandemic COVID-19 patients Electroporation ELISA epidemiological studies Epidemiological study flow cytometry HCW healthcare worker Humoral immunity identify IgA IgM increasingly International international standard international units Lateral flow test microneutralisation test Mild mild or asymptomatic infections multiplex neutralisation neutralisation assay Neutralising Antibodies neutralising antibody neutralising antibody response Neutralising antibody responses nucleocapsid positive correlation Prevalence protection pseudotyped RBD Re-infection respiratory Sample SARS-CoV-2 SARS-CoV-2 antigen SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 spike SARS-CoV-2-specific IgG Serological biomarkers SEROLOGICAL STUDY seronegative seropositive Severe acute respiratory syndrome Severe acute respiratory syndrome-related coronavirus Severe acute respiratory syndrome-related coronavirus-2 severe COVID-19 patient severe COVID-19 patients severity significantly higher spike statistically to define unit vaccination Vaccine vaccine trial variants of concern Virus neutralisation virus neutralisation assay virus neutralising antibody VoC were expressed WHO WHO guideline WHO International Standard World Health Organisation [DOI] 10.3389/fimmu.2021.748291 PMC 바로가기 [Article Type] Comparative Study
Persistence of Neutralizing Antibodies to SARS-CoV-2 in First Wave Infected Individuals at Ten Months Post-Infection: The UnIRSA Cohort Study감염 후 10 개월에 첫 파동 감염된 개체에서 SARS-COV-2에 대한 항체 중화 항체의 지속성 : UNIRSA 코호트 연구Brief Report Published on 2021-11-122022-09-01 Journal: Viruses [Category] MERS, SARS, 진단, [키워드] Anti-spike antibody binding domain Bio-Techne Cohort collected COVID-19 Critical elicited first positive First wave fraction geometric geometric mean humoral IgG antibody IgG titers immune response individual Infection Italy longitudinal longitudinal analysis Mild Mild disease Month natural infection neutralization titer Neutralizing activity neutralizing antibody neutralizing humoral response pandemic PCR test performed pseudotype public health R&D Systems RBD Re-infection SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 immunity seroconverted seronegative Seropositivity serum sample subject subjects USA Vaccine development was tested Wave were infected [DOI] 10.3390/v13112270 PMC 바로가기 [Article Type] Brief Report
SARS-CoV-2 Infection in One Cat and Three Dogs Living in COVID-19-Positive Households in Madrid, SpainVeterinary Science Published on 2021-11-102022-11-01 Journal: Frontiers in Veterinary Science [Category] COVID-19, [키워드] Alpha Alpha variant Analysis Asymptomatic B.1.1.7 lineage biochemical Blood bronchoalveolar cat Clinical signs collected Complete coughing COVID-19 COVID-19-positive households cycle threshold determine discharge dog Dyspnea exhibited Fever Genome healthy household IgG response Lineage B.1.1.7 lowest Mild nasal nasopharyngeal Oropharyngeal physical exam positive profiles Real-time reverse-transcription PCR rectal swab remained RT-qPCR SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 genome sequencing SARS-COV-2 infection SARS-CoV-2 testing seroconverted serology seronegative Spain variant virus weakness [DOI] 10.3389/fvets.2021.779341 PMC 바로가기 [Article Type] Veterinary Science
Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2기존의 중합효소 특이적 T 세포가 혈청 음성 반응을 일으키지 않는 SARS-CoV-2에서 확장Article Published on 2021-11-102022-09-10 Journal: Nature [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술, 치료제, [키워드] abortive infection accumulate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody Antibody binding Cell clades clearance of SARS-CoV-2 Cohort complex conserved contribute Coronaviridae coronavirus Coronavirus infection Coronavirus infections cross-protective detectable develop Endemic epitope expand exposure to HCoV HCW HCWs healthcare worker highlight IFI27 Immunological memory in vivo increase in individual Infection memory response memory T memory T cell Neutralization assay neutralization assays pandemic PCR refs Region Replication respiratory response responses RNA polymerase robust RTC SARS-CoV-2 SARS-COV-2 infection seasonal coronavirus Sequence conservation Seroconversion seronegative severe acute respiratory syndrome Coronavirus subclinical infection Support T cell T cells target targets tested the strongest these cell These cells transcribed Transcription Vaccine variant Viral viral control [DOI] 10.1038/s41586-021-04186-8 PMC 바로가기 [Article Type] Article