Sequence variation does not confound the measurement of plasma PfHRP2 concentration in African children presenting with severe malaria서열 변이는 중증 말라리아를 앓고 있는 아프리카 어린이의 혈장 PfHRP2 농도 측정을 혼란스럽게 하지 않는다.Research Published on 2012-08-162024-08-14 Journal: Malaria Journal [Category] 말라리아, [키워드] Africa Falciparum Histidine-rich protein malaria severe tandem repeat [DOI] 10.1186/1475-2875-11-276 PMC 바로가기 [Article Type] Research
Severe acute respiratory syndrome coronavirus accessory proteins 6 and 9b interact in vivoArticle Published on 2012-07-202022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] accessory protein accessory proteins acute respiratory syndrome Amino acid Analysis analyzed approach cellular conditions coronavirus Coronaviruses cytoplasm described eight ENCODE experiment Factor functions Genome homology immunoprecipitation in vivo infective Interaction involved LC–MS pathogenicity Protein Protein 6 Protein 9b protein–protein interactions Proteins proteomic Replication SARS Coronavirus SARS-CoV SARS-CoV infected cell SARS-CoV infected cells severe shown structural protein Viral protein virus [DOI] 10.1016/j.virusres.2012.07.012 PMC 바로가기 [Article Type] Article
Mechanism of Nucleic Acid Unwinding by SARS-CoV HelicaseResearch Article Published on 2012-05-152022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] acid base-pair carried catalytic demonstrated determined DNA double-stranded double-stranded RNA dsDNA dsRNA Efficiency ENhance enzyme experimental evidence Helicase hydrolysis IMPROVE kinetic analysis mechanism non-structural protein Nsp12 nsp13 nucleic acid nucleotide RdRP respiratory RNA synthesis RNA-dependent RNA polymerase SARS-CoV severe viral replication virus was used [DOI] 10.1371/journal.pone.0036521 PMC 바로가기 [Article Type] Research Article
Immunization with SARS Coronavirus Vaccines Leads to Pulmonary Immunopathology on Challenge with the SARS VirusResearch Article Published on 2012-04-202022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] acute respiratory syndrome antibody C57BL/6 candidate vaccine caution challenge change changes in China component control group country dosage eosinophil evaluated exhibited ferret Histopathology Human hypersensitivity immunopathology inactivated indicated Infection infiltration Influenza initiated led to Live virus lung Lung disease mice NHP occurred Occurrence pathologic PBS pulmonary responses Result S protein SARS Coronavirus SARS-CoV SARS-CoV vaccine serum antibody Serum neutralizing antibody severe Significant reduction significantly spread to Th2-type the vaccine Vaccine Vaccine development virus VLP [DOI] 10.1371/journal.pone.0035421 PMC 바로가기 [Article Type] Research Article
Reverse Genetics of SARS-Related Coronavirus Using Vaccinia Virus-Based RecombinationResearch Article Published on 2012-03-072022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] absence acute respiratory syndrome Analysis antiviral drug approach caused cDNA Cell characterization classical cloned Comparative analysis culture supernatant dendritic cell effective expressing facilitate Gene Expression generate Genome HCoV-229E Health Heterologous human coronavirus 229E in vitro transcription infectious Infectious virus led to less original form outbreak parental pathogenic plaque produced public health measures released Renilla luciferase Renilla luciferase gene Replication replication kinetics reporter reverse genetic system risk RNA transcript RNA transcripts robust SARS-CoV SARS-CoV Frankfurt-1 SARS-related coronavirus severe transfection Vaccines vaccinia vaccinia virus vectors virulent virus zoonotic disease [DOI] 10.1371/journal.pone.0032857 PMC 바로가기 [Article Type] Research Article
SARS Coronavirus nsp1 Protein Induces Template-Dependent Endonucleolytic Cleavage of mRNAs: Viral mRNAs Are Resistant to nsp1-Induced RNA CleavageResearch Article Published on 2011-12-082022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] 40S accelerated accompany acute respiratory syndrome Antiviral Author bind binding block cells characterized circumvent classical cleavage cleavage sites coronavirus cricket paralysis viruses Degradation demonstrated different element elements events exhibited facilitate Fever found function Hepatitis Host host gene expression host genes host mRNA host protein in vitro induce infected cells Infection inhibitor leader sequence Modification mRNA mRNAs nucleotide nucleotide sequence Protein protein synthesis recognize reporter Resistant ribosome RNA RNA modification SARS Coronavirus SARS infection severe severe symptom subunit suppress the expression susceptible translation type I type I interferon unique viral mRNA Viral protein virus virus replication [DOI] 10.1371/journal.ppat.1002433 PMC 바로가기 [Article Type] Research Article
Yeast Based Small Molecule Screen for Inhibitors of SARS-CoVResearch Article Published on 2011-12-022022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] activities activity Alter bypasse Cell culture cells cellular connection conserved Course demonstrated deubiquitinase Diversity expressed functional growth human coronaviruses induce induction Influenza virus inhibit inhibited inhibiting the function inhibitor inhibitory compounds investigated likelihood mammalian cells mechanism modify molecule Mortality NIH outbreak Papain-like protease phenotype PLP precursor protease Protease activity Replication reservoir Respiratory Coronavirus resulting S. cerevisiae SARS-CoV Screen severe shown small molecule suppressor toxic effect virus replication yeast [DOI] 10.1371/journal.pone.0028479 PMC 바로가기 [Article Type] Research Article
Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Regulates Cell Stress Response and ApoptosisResearch Article Published on 2011-10-202022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] absence activating Activation acute respiratory syndrome addition alleviate Apoptosis apoptotic Author Cell cell metabolism cell stress cells compared contribute contributed control cell different dissemination down-regulated drug drugs E gene E protein elicit envelope enzyme expressing expression Factor Gene Gene Expression homeostasis Host host gene expression identify immunoregulation in vivo increase in Infected Infection Inflammation involved lack mechanisms mutant pathway Pathways potential mechanism proinflammatory Proinflammatory cytokine PROTECT Protein reduced reduction reduction in regulated respiratory respiratory syncytial virus response reversed SARS-CoV SARS-CoV E severe Signal transduction signaling pathway Stress subset Transcription transcription factor treated Treatment unfolded protein response upregulated virus virus production was reduced [DOI] 10.1371/journal.ppat.1002315 PMC 바로가기 [Article Type] Research Article
Inhibition of SARS Pseudovirus Cell Entry by Lactoferrin Binding to Heparan Sulfate ProteoglycansResearch Article Published on 2011-08-222022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] ACE2 addition against SARS-CoV aggregation Analysis angiotensin-converting enzyme 2 binding binding site Cell cell entry cells Defense disease disrupt dose-dependent manner experiment functional Host host cell host cells Host immune response Infection inhibit inhibited inhibition inhibitory Interaction Invasion investigated involved lactoferrin neutrophil NK cell Pathogenesis prevented previous study protective role Proteoglycan pseudovirus pseudovirus infection receptor reported respiratory SARS-CoV severe shown Spike protein suggested sulfate Treatment [DOI] 10.1371/journal.pone.0023710 PMC 바로가기 [Article Type] Research Article
Crystal Structure and Functional Analysis of the SARS-Coronavirus RNA Cap 2′-O-Methyltransferase nsp10/nsp16 ComplexResearch Article Published on 2011-05-262022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] 2003 activating Activation antiviral drug assay association atomic resolution Author bind binding binding pocket CAP chromatin complex coronavirus crystal crystal structures disease enzyme etiological agent exhibit functional Genome Giant host cell identify inhibitor Innate immunity involved mechanism metabolism methyltransferase mRNA mutant non-structural protein Novel coronavirus nucleic acid performed Protein provide regulated Regulation replicate residue respiratory resulting RNA S-adenosylmethionine SAM severe Signal transduction stability Structure translation viruses [DOI] 10.1371/journal.ppat.1002059 PMC 바로가기 [Article Type] Research Article