In Silico Identification and Clinical Validation of a Novel Long Non-Coding RNA/mRNA/miRNA Molecular Network for Potential Biomarkers for Discriminating SARS CoV-2 Infection SeveritySARS CoV-2 감염 중증도를 판별하기 위한 잠재적 바이오마커에 대한 새로운 Long Non-Coding RNA/mRNA/miRNA 분자 네트워크의 실리코 식별 및 임상 검증Article Published on 2021-11-092022-09-11 Journal: Cells [Category] MERS, SARS, 바이오마커, 진단, [키워드] Analysis assays bioinformatics Biomarker Biomarkers circulating RNAs clinical clinically coding and non-coding RNAs Concordance controls coronavirus COVID-19 COVID-19 infection potential biomarker COVID-19 severity CRP Cytokines database determine develop diagnostic Diagnostic markers differential expression Diseases downregulation early infection Extensive ferritin Genetic Health health problem healthy controls healthy volunteers identification IL11RA IL11RA protein overexpression in silico in-silico infected patients Infection infection control interleukins genetic network LDH Long marker Mild molecular mRNA network Non-invasive novel pandemic Potential Potential biomarker potential biomarkers Predictive procalcitonin Protein Quantitative Quantitative RT-PCR response retrieved RNA RT-PCR SARS CoV-2 infection SARS-COV-2 infection severity prediction severe cases severe pneumonia severity significantly subject Symptoms the healthy upregulated Vaccine validation Validity variety [DOI] 10.3390/cells10113098 PMC 바로가기 [Article Type] Article
Pathogenic Basis of Thromboinflammation and Endothelial Injury in COVID-19: Current Findings and Therapeutic ImplicationsCOVID-19에서 혈소판 염증 및 내피 손상의 병원성 근거: 현재 연구 결과 및 치료적 시사점Review Published on 2021-11-082022-09-10 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 유전자 메커니즘, 치료제, [키워드] activities acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Atypical B cell responses Basis cardiovascular risk factors cause caused coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 current dry cough dysregulated dysregulated immune responses Endothelial dysfunction endothelial injury exacerbated Fever finding global pandemic high mortality highlight immune evasion immune responses Inflammation interferon interferon signaling interstitial pneumonia knowledge leads mechanisms morbidity Most patients multiple organ failure Organ failure Pathogenesis pathogenesis of COVID-19 pathogenic patients platelet activation platelet hyperactivation public health respiratory respiratory distress resulting SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe cases suppression symptoms of COVID-19 syndrome T cell therapeutic strategy Therapeutics Thromboembolism Thromboinflammation thrombosis [DOI] 10.3390/ijms222112081 PMC 바로가기 [Article Type] Review
A Novel COVID-19 Diagnosis Support System Using the Stacking Approach and Transfer Learning Technique on Chest X-Ray Images흉부 X선 영상에 대한 적층 접근법 및 전이 학습 기법을 사용한 새로운 코로나19 진단 지원 시스템Research Article Published on 2021-11-052022-09-10 Journal: Journal of Healthcare Engineering [Category] MERS, SARS, 치료기술, [키워드] Accuracy Algorithm approach best chest X-ray Chest X-ray image Chest X-ray images Convolutional neural network cough COVID-19 dataset deep learning detect develop diagnosing Diagnosis disease-causing evaluate Fever Image Infectious disease knowledge learning Measures medical diagnosis novel patients with COVID-19 Pneumonia Radiographic respiratory robustness Severe case severe cases Support Support System Symptom System technique transfer Tuberculosis Viral Viral pneumonia was collected X-ray [DOI] 10.1155/2021/9437538 PMC 바로가기 [Article Type] Research Article
437. Longitudinal Plasma Cytokine Profiles Differentiating COVID-19 Severity GroupsPoster Abstracts Published on 2021-11-042022-10-29 Journal: Open Forum Infectious Diseases [Category] COVID-19, [키워드] acute COVID-19 acute respiratory syndrome age analyzed assigned association Asymptomatic blood sample cause children Clinical severity cohorts consultant convalescent convalescent plasma coronavirus coronavirus disease COVID-19 criteria CSS cytokine cytokine level cytokine profile Cytokine storm syndrome Disease progression elevated enrolled figure GCSF group hospital Hospitalization Hospitalized IL-10 IL-15 IL-8 Inc Infection Inflammatory Inflammatory response IP-10 Joshua less longitudinal Mild mild cases MIP-1β MIS-C moderate moderate-severe nothing participant Participants Patient PCR Phenotypes plasma sample polymerase chain positive profile Prospective Quantitative response Result SARS-CoV-2 SARS-CoV-2 PCR severe cases severe COVID-19 severe group Severe patient severity Severity Score significant difference syndrome Temporal tested Thomas timepoint timepoints Treatment Wolf [DOI] 10.1093/ofid/ofab466.636 PMC 바로가기 [Article Type] Poster Abstracts
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Encephalitis Is a Cytokine Release Syndrome: Evidences From Cerebrospinal Fluid Analyses중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2) 뇌염은 사이토카인 방출 증후군입니다: 뇌척수액 분석의 증거Article Published on 2021-11-022022-09-12 Journal: Clinical Infectious Diseases: An Official Publicat [Category] MERS, SARS, 진단, [키워드] Acidic Activation acute respiratory syndrome alteration Blood brain barrier cerebrospinal fluid coronavirus coronavirus 2 COVID-19 CSF CXCL13 Cytokine release syndrome Cytokine storm Cytokine storm syndrome cytokine-release syndrome dysfunction Encephalitis endothelial exhibited expressed GFAp healthy control ICANS IL-6 IL-8 Immune-mediated indicated Inflammatory Inflammatory biomarker investigated marker mechanism mechanisms myeloid cell Necrosis neurological manifestation neuronal Patient polymerase chain Protein Real-time PCR recent Release respiratory SARS-CoV-2 SARS-COV-2 infection Severe case severe cases soluble Triggering Receptor suggested TNF- α YKL-40 [DOI] 10.1093/cid/ciaa1933 PMC 바로가기 [Article Type] Article
Economic evaluation of remdesivir for the treatment of severe COVID-19 patients in China under different scenarios다양한 시나리오에서 중국의 중증 COVID-19 환자 치료를 위한 렘데시비르의 경제적 평가Article Published on 2021-11-012022-09-11 Journal: British Journal of Clinical Pharmacology [Category] 치료제, [키워드] analysed Analysis Asymptomatic calibrated calibration China cost-effectiveness Cost-effectiveness analysis COVID-19 Decision tree disease Epidemic epidemic curve evaluate Evidence Health Healthcare system Hospitalized intensities life outcome parameter variation parameters Patient Perspective presymptomatic Quality of life regimen Remdesivir replaced REPLACED BY representing robust Sensitivity analyses Severe case severe cases severe COVID-19 patient severe COVID-19 patients Standard of care threshold Transmission model Treatment Wuhan [DOI] 10.1111/bcp.14860 PMC 바로가기 [Article Type] Article
[Attending COVID-19 patients during the first wave of the pandemic in a Medium Stay Hospital: Variables associated with mortality in hospitalized patients in an acute situation][코로나19 팬데믹 1차 유행하는 중형병원 입원환자 진료: 급성기 입원환자 사망률 관련 변수]Observational Study Published on 2021-11-012022-09-11 Journal: Revista española de geriatría y gerontología [Category] SARS, 임상, 치료기술, [키워드] acute mortality affected age analysed Analysis Atención hospitalaria Characteristics Charlson index collected Comorbidity Comorbilidad convalescent phase cough country COVID-19 COVID-19 patient COVID-19 patients creatinine CURB Deceased elderly elevated English Factor Fever First wave functional hospital care hospitalized patient hypoproteinemia identify independent independent risk factor independent risk factors interquartile range kidney Kidney failure Malnutrition material Mental Mortalidad Mortality Multivariate analysis observational study PaFi Pandemia pandemic Patient Persona Persona mayor. Pneumonia radiological renal respiratory Respiratory failure SARS-CoV-2 SARS-CoV-2 pandemic severe cases Spain Spanish survivor Symptom the median the patient the SARS-CoV-2 therapeutic treated urea variable [DOI] 10.1016/j.regg.2021.05.006 PMC 바로가기 [Article Type] Observational Study
Vitamin C Intervention for Critical COVID-19: A Pragmatic Review of the Current Level of EvidenceReview Published on 2021-11-012022-10-29 Journal: International Review of Cell and Molecular Biology [Category] COVID-19, [키워드] acute phase acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome adverse event antioxidant appear ARDS cause characterized clinical trial clinical trials coronavirus coronavirus disease COVID-19 COVID-19 patients current decrease dose elevated Evidence FIVE hospital IMPROVE Infection Inflammation inflammatory markers Intervention intravenous intravenous vitamin C less Level Oxygenation parameters patients with pneumonia Pneumonia randomised controlled trial Randomised controlled trials RCT RCTs reactive oxygen specy reduce reduce mortality reported respiratory infection retrospective cohort review ROS SARS-CoV-2 SARS-CoV2 Sepsis Seven severe cases severely ill patients severity survival rate syndrome the disease Trial Upcoming Vitamin Vitamin C with COVID-19 [DOI] 10.3390/life11111166 PMC 바로가기 [Article Type] Review
Serum periostin levels in COVID-19: Is it useful as a new biomarker?COVID-19의 혈청 페리오스틴 수치: 새로운 바이오마커로 유용합니까?Article Published on 2021-11-012022-09-11 Journal: International journal of clinical practice [Category] MERS, SARS, 바이오마커, [키워드] Beta Biomarker can be used control group coronavirus coronavirus disease COVID COVID-19 COVID-19 pneumonia develop disease ELISA ELISA kits enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay Follow-up groups growth factor healthy control in some interstitial pneumonia manuscript Patient patients with COVID-19 Periostin Pneumonia respiratory respiratory diseases serum Severe case severe cases severe disease severity significantly higher tested TGF-β the disease transforming growth factor two groups [DOI] 10.1111/ijcp.14728 PMC 바로가기 [Article Type] Article
Biomarkers of endothelial dysfunction and outcomes in coronavirus disease 2019 (COVID-19) patients: A systematic review and meta-analysis코로나바이러스 2019(COVID-19) 환자의 내피 기능 장애 및 결과의 바이오마커: 체계적인 검토 및 메타 분석Meta-Analysis Published on 2021-11-012022-09-11 Journal: Microvascular research [Category] 바이오마커, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis Antigen Biomarker Biomarkers Coagulopathy conducted confidence interval coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients database Deceased Endothelial cell endothelial cells Endothelial dysfunction Factor healthy control highest infect mean difference Meta-analysis observational studies observational study outcome Patient patients with COVID-19 plasma plasminogen Plasminogen activator inhibitor-1 Prognostic value PROSPERO registration number reported respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus Severe case severe cases significantly SMD systematic review thrombomodulin tissue Tissue-type plasminogen activator von Willebrand factor vWF [DOI] 10.1016/j.mvr.2021.104224 PMC 바로가기 [Article Type] Meta-Analysis