Comparison of the diagnostic efficacy between two PCR test kits for SARS‐CoV‐2 nucleic acid detectionResearch Article Published on 2020-09-252022-10-30 Journal: Journal of Clinical Laboratory Analysis [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome analyzed Biotechnology China clinically collected coronavirus coronavirus disease COVID‐19 diagnosed diagnostic diagnostic efficacy Efficacy hospitalized patient N gene Negative predictive value NPV nucleic acid Nucleic acid detection ORF1ab PCR PCR kit PCR test performed polymerase chain positive Positive predictive value PPV Result reverse transcription RT‐PCR RT‐PCR test SARS‐CoV‐2 SARS‐CoV‐2 sensitivity Shanghai specificity swab sample Throat throat swab Variation [DOI] 10.1002/jcla.23554 PMC 바로가기 [Article Type] Research Article
Efficacy of Early Combination Therapy With Lianhuaqingwen and Arbidol in Moderate and Severe COVID-19 Patients: A Retrospective Cohort StudyPharmacology Published on 2020-09-182022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] accelerate acute respiratory syndrome adverse events Arbidol benefit Chest CT China city Combination combination therapy conducted coronavirus coronavirus disease COVID-19 COVID-19 patient drug enrolled global pandemic Hospital stay IMPROVE Inpatient LianhuaQingwen material moderate Moderate COVID-19 monotherapy negativity nucleic acid objective outbreak patients with moderate prognosis of patient reducing Result retrospective cohort study Ruijin SARS-CoV-2 severe COVID-19 patient severe group Shanghai significantly therapeutic drug time to conversion Tongji Hospital treat treated two group Wuhan Wuhan, China [DOI] 10.3389/fphar.2020.560209 PMC 바로가기 [Article Type] Pharmacology
Risks and features of secondary infections in severe and critical ill COVID-19 patientsResearch Article Published on 2020-09-082022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, MERS, SARS, [키워드] accompanied Admission Bacteria blood sample Characteristics clinical collected COVID-19 COVID-19 patient Critical critical COVID-19 patient critical COVID-19 patients Culture described diagnostic discharge rate feature fungi Infection infection rate infections intensive care intravascular devices intubation invasive Invasive mechanical ventilation laboratory data mortality rate objective pathogen Patient performed Prognosis proportion receiving respiratory respiratory infections respiratory ventilations Result risk SARS-CoV-2 Secondary infection secondary infections Sequencing severe COVID-19 Shanghai tracheal Urine Ventilation virus worsened [DOI] 10.1080/22221751.2020.1812437 PMC 바로가기 [Article Type] Research Article
Research Collaboration and Outcome Measures of Interventional Clinical Trial Protocols for COVID-19 in ChinaPublic Health Published on 2020-09-022022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] Beijing China Chinese clinical clinical trial clinical trials collaboration conducted contributed COVID-19 deficiency distribution dosage drug expression generate Hospital stay information Intervention lack measure outcome outcome measure outcome measures outcomes Primary outcome protocol Region Registered registry Research research collaboration researcher SARS-CoV-2 Science searched secondary outcome Shanghai statistical analysis technology Tongji Hospital Tongji Medical College Treatment Trial university was used Wuhan [DOI] 10.3389/fpubh.2020.554247 PMC 바로가기 [Article Type] Public Health
Severe Coronavirus disease 2019 pneumonia patients showed signs of aggravated renal impairmentResearch Article Published on 2020-08-252022-10-30 Journal: Journal of Clinical Laboratory Analysis [Category] COVID-19, MERS, SARS, [키워드] acid acute respiratory syndrome biological marker C‐reactive protein Clinical Center collected Concentration coronavirus Coronavirus disease 2019 COVID‐19 COVID‐19 patient COVID‐19 CREA creatinine erythrocyte sedimentation ESR female FIVE hs‐CRP identify indicated Infection Inflammatory response Kidney function male Mild Patient PCT Pneumonia Pro procalcitonin Protein public health renal impairment Result Sample SARS‐CoV‐2 sensitive indicator serum severe group Severe patient severe patients Shanghai significant difference tested UA urea Urine urine protein [DOI] 10.1002/jcla.23535 PMC 바로가기 [Article Type] Research Article
Corticosteroid prevents COVID-19 progression within its therapeutic window: a multicentre, proof-of-concept, observational studyResearch Article Published on 2020-08-212022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, MERS, [키워드] 95% confidence interval acute respiratory distress benefit characterized Cohort control group coronavirus disease Corticosteroid Corticosteroids COVID-19 COVID-19 patient COVID-19 progression Critically ill patient early phase enrolled excessive inflammation Hypothesis Invasive mechanical ventilation LDH less limit marker multicentre Patient patients Prevent Primary outcome progression proportion Radiographic radiologic SARS-CoV-2 Shanghai significantly lower syndrome therapeutic therapeutic window treated ULN validation cohort [DOI] 10.1080/22221751.2020.1807885 PMC 바로가기 [Article Type] Research Article
Three infection clusters related with potential pre-symptomatic transmission of coronavirus disease (COVID-19), Shanghai, China, January to February 2020Outbreaks Published on 2020-08-202022-10-31 Journal: Eurosurveillance [Category] COVID-19, Fulltext, MERS, [키워드] China Cluster collected Contact coronavirus disease COVID-19 COVID-19 case COVID-19 cases demographic characteristics epidemiological Evidence FIVE hospital illness onset Incubation period indicate Infection infection cluster information Isolation Measures Novel coronavirus occur occurred person-to-person transmission polymerase chain pre-symptomatic pre-symptomatic transmission provide respiratory rRT-PCR SARS-CoV-2 secondary case Shanghai specimen tested trajectory Transmission [DOI] 10.2807/1560-7917.ES.2020.25.33.2000228 PMC 바로가기 [Article Type] Outbreaks
Genome-wide analysis of SARS-CoV-2 virus strains circulating worldwide implicates heterogeneityArticle Published on 2020-08-192022-10-04 Journal: Scientific Reports [Category] MERS, 변종, 유전자 메커니즘, [키워드] ACE2 acute respiratory syndrome Amino acid Analysis analyzed angiotensin-converting enzyme 2 annotation arginine Asia Belgium Case fatality rate circulating coding sequence Complete Computational biology and bioinformatics conserved Coronavirus-2 COVID-19 pandemic Deletion domain effective England epidemiological data epitope Europe European Evolution Frame France Frequency genetic variants genetics Genome genome sequence genomic GISAID database globe heterogeneous implication Interaction Italy lysine Microbiology Mutation Netherlands neutralizing antibody North America nucleotide ORF10 ORF1ab ORF7a pandemic polyprotein Prophylaxis Protein Proteins RBD remained reported residue responsible RNA virus SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 strain SARS-CoV-2 virus strain sequence Shanghai Spain Substitution the SARS-CoV-2 genome Variation Viral protein virus strains [DOI] 10.1038/s41598-020-70812-6 PMC 바로가기 [Article Type] Article
Massive migration promotes the early spread of COVID-19 in China: a study based on a scale-free networkResearch Article Published on 2020-08-102022-10-29 Journal: Infectious Diseases of Poverty [Category] COVID-19, MERS, [키워드] affected Analysis applied autonomous Beijing China collected coronavirus disease correlated correlation COVID-19 COVID-19 epidemic eight Epidemic Epidemics evaluate explain Lunar New Year massive Migration Nanjing nine promote R package Region regions Result scale-free network selected Shanghai Shenzhen spread of COVID-19 spring the epidemic Tianjin WGCNA Wuhan [DOI] 10.1186/s40249-020-00722-2 PMC 바로가기 [Article Type] Research Article
Early Warning Indicators of Severe COVID-19: A Single-Center Study of Cases From Shanghai, ChinaMedicine Published on 2020-07-172022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] abnormal coagulation abnormality addition Admission Adult adult COVID-19 patient age Analysis C-reactive protein CD4/CD8 center China clinical Comorbidities condition COVID-19 Critical D-dimer death develop diabete disease Disease progression early warning indicators epidemiological examined four group higher risk identify Indicator Laboratory lactate dehydrogenase Lymphocytes management Mild moderate moderate disease moderate patients Neutrophils novel coronavirus disease organ damage Patient patients predictor procalcitonin prognostic progressed progression Public remained risk factor serum severe COVID-19 severe disease severe patients Shanghai Shortness of breath survival curve treated [DOI] 10.3389/fmed.2020.00432 PMC 바로가기 [Article Type] Medicine