Signal transduction – Page 11 – Communicable Diseases Research

Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Regulates Cell Stress Response and Apoptosis

Research Article

Published on 2011-10-202022-10-29
Journal: PLoS Pathogens [Category] Coronavirus, MERS,

[키워드] absence activating Activation acute respiratory syndrome addition alleviate Apoptosis apoptotic Author Cell cell metabolism cell stress cells compared contribute contributed control cell different dissemination down-regulated drug drugs E gene E protein elicit envelope enzyme expressing expression Factor Gene Gene Expression homeostasis Host host gene expression identify immunoregulation in vivo increase in Infected Infection Inflammation involved lack mechanisms mutant pathway Pathways potential mechanism proinflammatory Proinflammatory cytokine PROTECT Protein reduced reduction reduction in regulated respiratory respiratory syncytial virus response reversed SARS-CoV SARS-CoV E severe Signal transduction signaling pathway Stress subset Transcription transcription factor treated Treatment unfolded protein response upregulated virus virus production was reduced
[DOI] 10.1371/journal.ppat.1002315 PMC 바로가기 [Article Type] Research Article

MK2-Dependent p38b Signalling Protects Drosophila Hindgut Enterocytes against JNK-Induced Apoptosis under Chronic Stress

MK2-의존성 p38b 신호는 만성 스트레스 하에서 JNK 유도 세포자멸사로부터 Drosophila Hindgut Enterocytes를 보호합니다

Research Article

Published on 2011-08-042022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] absence addressed affected antimicrobial peptides Apoptosis atrophy Author branch cascade Cell chronic complex component contribute damage damaged descendants Deterioration Diseases Drosophila Elimination Enterocyte enterocytes epithelial epithelium event form genetic analysis Gut Hindgut homeostasis Impaired induce integrity intestinal Intestinal diseases intestinal epithelium intestinal stem cell Intestinal stem cells JNK kinases leads less manifested pathogen Pathogens pathway peptides peptides) Prevent proliferation PROTECT Protective Protein protein kinase replaced REPLACED BY Replenishment required salt Signal transduction stem cell stem cells Stress Stressor stressors subsequent suppresse Trigger triggers upregulated upstream
[DOI] 10.1371/journal.pgen.1002168 PMC 바로가기 [Article Type] Research Article

Crystal Structure and Functional Analysis of the SARS-Coronavirus RNA Cap 2′-O-Methyltransferase nsp10/nsp16 Complex

Research Article

Published on 2011-05-262022-10-29
Journal: PLoS Pathogens [Category] Coronavirus,

[키워드] 2003 activating Activation antiviral drug assay association atomic resolution Author bind binding binding pocket CAP chromatin complex coronavirus crystal crystal structures disease enzyme etiological agent exhibit functional Genome Giant host cell identify inhibitor Innate immunity involved mechanism metabolism methyltransferase mRNA mutant non-structural protein Novel coronavirus nucleic acid performed Protein provide regulated Regulation replicate residue respiratory resulting RNA S-adenosylmethionine SAM severe Signal transduction stability Structure translation viruses
[DOI] 10.1371/journal.ppat.1002059 PMC 바로가기 [Article Type] Research Article

The SARS-Unique Domain (SUD) of SARS Coronavirus Contains Two Macrodomains That Bind G-Quadruplexes

Research Article

Published on 2009-05-152022-10-29
Journal: PLoS Pathogens [Category] Coronavirus,

[키워드] 2003 acute respiratory syndrome ADP-ribose amino-acid Apoptosis Author bats bind binding coding compared component concerning coronavirus crystal structure determine determined different domain Evidence extreme form found function functional G-quadruplex gel electrophoresis Genome genomic RNA help homodimer host cell humans immune response in vitro include Infected involved lysine macrodomain mild infection monomer mRNA Mutation non-structural protein nucleic acid nucleotides nucleus occur oligonucleotide other coronaviruses outbreak pathogenicity Possible Protein protein 3 reduction Region regulate related virus remained Replication residue residues responsible RNA SARS Coronavirus SARS-CoV selected Seven shown Signal transduction Structure structures target three-dimensional structure Transcription viral infection viral replication virus X-ray crystallography
[DOI] 10.1371/journal.ppat.1000428 PMC 바로가기 [Article Type] Research Article