NICEdrug.ch, a workflow for rational drug design and systems-level analysis of drug metabolismTools and Resources Published on 2021-08-032022-10-31 Journal: eLife [Category] COVID-19, [키워드] alleviate Analysis anticancer candidate drug Cell COVID-19 database dataset drug drug clustering drug design drug metabolic fate drug similarity E. coli enzyme Enzyme inhibition evaluate explain golden standard high risk Human human host identify include inhibitory Intensive ligand-based drug discovery malaria mechanism metabolism metabolite nutraceuticals P. falciparum reactive reactivity reduce Research resource Side effects similarity small molecule targets toxicities Toxicity unique [DOI] 10.7554/eLife.65543 PMC 바로가기 [Article Type] Tools and Resources
A systems‐level study reveals host‐targeted repurposable drugs against SARS‐CoV‐2 infection시스템 수준의 연구에 따르면 SARS -COV -2 감염에 대한 숙주 대상 재구성 가능한 약물이 밝혀졌습니다.Article Published on 2021-08-022022-08-31 Journal: Molecular Systems Biology [Category] MERS, SARS, 신약개발, 유전자 메커니즘, 치료제, [키워드] A549 A549 cell A549 cells activities Analysis antiviral activities antiviral activity approach autophagy brompheniramine Cell Cell fusion cells Chemical biology Compound connectivity COVID‐19 COVID‐19 patients disease drug drug candidate Effects exhibited Ezetimibe gene expression signature HEK293T hexylresorcinol host cells Hyperinflammatory response hyperinflammatory responses identify imipramine independent inhibitory linsitinib Map mechanism Microbiology, Virology & Host Pathogen Interaction mTOR mTOR inhibitor predicted Quantitative repertoire reveal rottlerin salmeterol SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2‐infected SARS‐CoV‐2‐infected cell transcriptomics screened small molecule Small molecules syncytia formation target host cell Therapeutics Transcriptome understanding Viral viral entry viral–host interactions [DOI] 10.15252/msb.202110239 PMC 바로가기 [Article Type] Article
TRP channels in COVID-19 disease: Potential targets for prevention and treatmentReview article Published on 2021-08-012022-10-05 Journal: Chemico-biological interactions [Category] 치료법, [키워드] acute respiratory syndrome Ageusia angiotensin-converting enzyme 2 Anosmia antibodies caused Compound coronavirus Coronavirus disease 2019 cough COVID-19 COVID-19 disease desensitization Effectiveness expressed Fever Health highlight Inflammation literature mechanism Neurological complication Pain Patient Pneumonia Potential Potential treatment prevention problems protease Protein provide SARS-CoV-2 serine 2 small molecule Symptom Symptoms target Treatment TRP TRP channels various tissue [DOI] 10.1016/j.cbi.2021.109567 [Article Type] Review article
A multimodal deep learning-based drug repurposing approach for treatment of COVID-19COVID-19의 치료를위한 멀티 모달 딥 러닝 기반 약물 재검사 접근법Article Published on 2021-08-012022-08-31 Journal: Molecular diversity [Category] 신약개발, [키워드] applied approach chemical structures Cluster computational method COVID-19 deep deep learning demonstrated differentially expressed gene Differentially expressed genes distribution drug Drug repurposing drugs dysregulated feature Features information machine medication Medicine Medicines modality Multimodal data fusion perturbations Probability probability distribution problem RBM Restricted Restricted Boltzmann machine. resulting Side effects small molecule Small molecules source code Structure therapeutic treat Treatment was used were used [DOI] 10.1007/s11030-020-10144-9 PMC 바로가기 [Article Type] Article
Remdesivir for the treatment of Covid-19: the value of biochemical studies코로나19 치료를 위한 렘데시비르: 생화학 연구의 가치Review Published on 2021-08-012022-09-11 Journal: Current opinion in virology [Category] SARS, 치료제, [키워드] acting active form animal model animal models Antiviral Antiviral effect antiviral effects benefit biochemical cause cell cultures copy Delayed drug target effort expected incorporation infection with SARS-CoV-2 inhibited mechanism mechanism of action nucleotide patients Proofreading provide Remdesivir RNA genome RNA polymerase RNA synthesis RNA-dependent RNA polymerase small molecule Template Treatment viral load reduction Viral RNA viral RNA-dependent RNA polymerase [DOI] 10.1016/j.coviro.2021.04.014 PMC 바로가기 [Article Type] Review
High-throughput human primary cell-based airway model for evaluating influenza, coronavirus, or other respiratory viruses in vitroArticle Published on 2021-07-222022-10-04 Journal: Scientific Reports [Category] SARS, 치료제, [키워드] absence ACE2 air–liquid interface airway airway epithelial cell animal models Antiviral antiviral agent biomedical engineering Camostat mesylate can be used Combination coronavirus Coronavirus infections Coronaviruses COVID-19 Culture Donor effective Efficacy evaluate expression HCoV-NL63 host cell Human human primary cells immortalized cell line in vitro Infection Influenza influenza A virus inhibitor National other respiratory virus Pandemics platform Population Predictive priming protease TMPRSS2 public health robust SARS-CoV-2 small molecule Spike protein strain therapeutic efficacy tissue viral infection [DOI] 10.1038/s41598-021-94095-7 PMC 바로가기 [Article Type] Article
Nodosome Inhibition as a Novel Broad-Spectrum Antiviral Strategy against Arboviruses, Enteroviruses, and SARS-CoV-2아르보바이러스, 엔테로바이러스 및 SARS-CoV-2에 대한 새로운 광범위한 항바이러스 전략으로서의 Nodosome 억제Article Published on 2021-07-162022-09-11 Journal: Antimicrobial Agents and Chemotherapy [Category] SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alphaviruses Antiviral antiviral activity Antiviral effect arbovirus Arboviruses Brain broad spectrum broad-spectrum antiviral broad-spectrum antivirals causative agent Cell coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 coxsackievirus downstream drug enhancement expression fetal function Host induce Infection inhibit inhibition inhibitor interferon interferon response NOD2 nodosome. novel nucleotide observation oligomerization pathogenic promote Protein protein kinase Replication RIPK2 RNA viruses SARS-CoV-2 Serine severe acute respiratory syndrome Coronavirus shown small molecule Spread Strategy target the interferon threonine Zika virus ZIKV [DOI] 10.1128/AAC.00491-21 PMC 바로가기 [Article Type] Article
Rapid and Sensitive Inhibitor Screening Using Magnetically Modulated BiosensorsArticle Published on 2021-07-142022-10-29 Journal: Sensors (Basel, Switzerland) [Category] COVID-19, SARS, [키워드] ACE2 acute respiratory syndrome angiotensin-converting enzyme 2 binding biosensor coronavirus COVID-19 pandemic drug candidates ELISA enzyme-linked immunosorbent faster in vitro inhibitor Inhibitor screening Interaction magnetically aggregated biosensors modulated Neutralizing antibodies neutralizing antibody non-specific Rapid receptor SARS-CoV-2 Screening sensitive small molecule Small molecules Spike protein the spike protein [DOI] 10.3390/s21144814 PMC 바로가기 [Article Type] Article
Current Perspectives in the Discovery of Newer Medications Against the Outbreak of COVID-19Molecular Biosciences Published on 2021-07-122022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] ACE-2 ACE-2 receptor Against age approaches Asymptomatic bind candidate cardiovascular disease clinical trials coronavirus COVID-19 COVID-19 disease current death diagnostic Effect effort Health Host human lung identify in-silico manuscript medication Mild new strain outbreak pandemic disease patients patients of COVID-19 peptides Perspective PROTECT researcher Respiratory disease SARS-CoV-2 severe respiratory illness small molecule Spike protein Spread spread of COVID-19 suggested target the spike protein the vaccine therapeutic targets treat Treatment viral entry virus [DOI] 10.3389/fmolb.2021.648232 PMC 바로가기 [Article Type] Molecular Biosciences
Detection of Binding Sites on SARS-CoV-2 Spike Protein Receptor-Binding Domain by Molecular Dynamics Simulations in Mixed Solvents혼합 용매의 분자 역학 시뮬레이션을 통한 SARS-CoV-2 스파이크 단백질 수용체 결합 도메인의 결합 부위 검출Article Published on 2021-07-012022-09-11 Journal: IEEE/ACM transactions on computational biology and [Category] SARS, 신약개발, 치료기술, 치료제, [키워드] accelerate accelerated ACE2 ACE2 binding ACE2 receptor addition angiotensin antibody attachment binding site Compound described detection domain Drug discovery Drug repurposing Dynamics effective drug effective drugs finding identify inhibit inhibitor insight Interaction molecular dynamics Molecular dynamics simulation molecular dynamics simulations observation offer pathogen Prevent probe Protein protocol RBD RBD-ACE2 receptor S protein SARS-CoV-2 SARS-COV-2 infection Simulation Site small molecule Small molecules solvent spike suggested the disease the S protein viral entry Virtual screening [DOI] 10.1109/TCBB.2021.3076259 PMC 바로가기 [Article Type] Article