Study protocol of the Edinburgh and Lothian Virus Intervention Study in Kids: a randomised controlled trial of hypertonic saline nose drops in children with upper respiratory tract infections (ELVIS Kids)어린이에 대한 에딘버러 및 로시안 바이러스 중재 연구의 연구 프로토콜: 상부 호흡기 감염이 있는 어린이의 고장성 식염수 점비제에 대한 무작위 대조 시험(ELVIS Kids)Article Published on 2021-05-052022-09-11 Journal: BMJ Open [Category] SARS, 임상, [키워드] 24 hour 24 hours 48 hour 48 hours age All participant All participants approved asked Asymptomatic board Care Child child health children chloride clinical Community community child health Complete Contact control arm Controlled trial determine Edinburgh Ethics events Health hypertonic hypertonic saline immunisation Infection Infectious disease Intervention intervention arm Local media nasal swab National Health Service neonatology nose drop nose drops nostril office Open-label paediatric infectious disease & Participation partnership peer-reviewed primary care protocol provided questionnaire randomised randomised controlled trial recruited recruitment registration number Research Research Ethics satisfaction questionnaire service Sodium chloride standard care Symptom symptomatic university upper respiratory tract upper respiratory tract infection URTI URTI symptom URTI symptoms Virology website West wheeze [DOI] 10.1136/bmjopen-2021-049964 PMC 바로가기 [Article Type] Article
Standard Care Versus Awake Prone Position in Adult Nonintubated Patients With Acute Hypoxemic Respiratory Failure Secondary to COVID-19 Infection—A Multicenter Feasibility Randomized Controlled TrialCOVID-19 감염에 따른 급성 저산소성 호흡부전이 있는 성인 삽관되지 않은 성인 환자의 깨어 있는 자세와 깨어 있는 자세 비교 - 다기관 타당성 무작위 대조 시험Randomized Controlled Trial Published on 2021-05-052022-08-13 Journal: Journal of Intensive Care Medicine [Category] MERS, 임상, [키워드] 6 hour 6 hours acute hypoxic respiratory failure acute respiratory distress acute respiratory distress syndrome adverse events Awake prone positioning clinical trial conditions conducted Controlled COVID-19 COVID-19 pneumonia exceeded failure feasibility Feasibility study feasible group help hypoxia hypoxic respiratory failure knowledge maintain no significant difference non-intubated patient non-intubated patients observational studies observational study outcome oxygen pandemic parallel group Patient Pneumonia position Primary outcome prone prone group Prone position prone positioning proportion protocol Randomized rationale recruited requiring supplemental oxygen respiratory respiratory distress Respiratory failure Result Safe saturation secondary outcome Secondary outcomes secondary to significant difference Standard standard care supine supine group supplemental oxygen syndrome Trial with COVID-19 [DOI] 10.1177/08850666211014480 PMC 바로가기 [Article Type] Randomized Controlled Trial
Tocilizumab plus standard care versus standard care in patients in India with moderate to severe COVID-19-associated cytokine release syndrome (COVINTOC): an open-label, multicentre, randomised, controlled, phase 3 trial인도에서 중등도에서 중증의 COVID-19 관련 사이토카인 방출 증후군(COVINTOC) 환자에 대한 토실리주맙과 표준 치료 대 표준 치료: 공개, 다기관, 무작위 배정, 대조, 3상 시험Clinical Trial Published on 2021-05-012022-09-12 Journal: The Lancet. Respiratory Medicine [Category] Fulltext, SARS, 임상, 진단, [키워드] 1:1 Action acute respiratory distress adverse event adverse events analyses anti-IL-6 receptor antibody assigned baseline Block randomisation Cipla clinical country COVID-19 COVID-19 progression Cytokine release syndrome death decrease discharge education effective eight Evidence FIVE Follow-up grade 3 hospital India intensive care investigated mechanical ventilation medication Ministry of Health moderate modified intention-to-treat multicentre occurred one patient Open-label participant Patient patients died phase 3 trial positive SARS-CoV-2 PCR post-hoc Prevent primary endpoint progression Racial randomised randomised controlled trial Randomly randomly assigned patients receive recruited reduced Registered registry reported Roche routine Safety Serious Adverse Events Seven severe COVID-19 shown standard care standard care group supported syndrome the primary endpoint Tocilizumab Treatment Trial with COVID-19 [DOI] 10.1016/S2213-2600(21)00081-3 PMC 바로가기 [Article Type] Clinical Trial
Statistical Decision Properties of Imprecise Trials Assessing Coronavirus Disease 2019 (COVID-19) DrugsResearch article Published on 2021-05-012022-10-05 Journal: Value in health : the journal of the International [Category] 임상, [키워드] Assessing average Care clinical decision clinician coronavirus disease COVID-19 criteria criterion decision decision criteria drug estimate evaluate Experimental drugs highest hypothesis test hypothesis tests IMPROVE magnitude near optimality objective outcome Patient Perspective positive Probability property randomized trial randomized trials reported Result sample sizes standard care statistical statistically significant treat Treatment treatment effect Trial trials [DOI] 10.1016/j.jval.2020.11.019 [Article Type] Research article
Therapeutic plasma exchange in patients with life-threatening COVID-19: a randomised controlled clinical trialRandomized Controlled Trial Published on 2021-05-012022-10-04 Journal: International journal of antimicrobial agents [Category] 임상, [키워드] 95% CI acute respiratory distress syndrome addition age Analysis ARDS assessment association Care clinical trial COVID-19 COVID-19 patients Cytokine release syndrome D-dimer Day distress Efficacy enrolled faster clinical recovery ferritin hyperinflammation ICU ICU patient inflammatory biomarkers intensive care unit interleukin-6 IQR Kaplan-Meier lactate dehydrogenase life-threatening LOS lymphocyte Mortality Multivariable regression analysis on mechanical ventilation Open-label Organ failure outcome PaO Patient plasma positive predictor provided randomised randomised controlled reduction in RT-qPCR secondary Sepsis serum lactate SOFA score Standard standard care standard treatment stratified Therapeutic plasma exchange therapy Thromboinflammation TPE Treatment [DOI] 10.1016/j.ijantimicag.2021.106334 PMC 바로가기 [Article Type] Randomized Controlled Trial
Interferon-beta offers promising avenues to COVID-19 treatment: a systematic review and meta-analysis of clinical trial studies인터페론 베타는 COVID-19 치료에 대한 유망한 방법을 제공합니다: 임상 시험 연구의 체계적인 검토 및 메타 분석Meta-Analysis Published on 2021-05-012022-09-11 Journal: Naunyn-Schmiedeberg's Archives of Pharmacology [Category] 임상, 치료제, [키워드] accompanied acute respiratory syndrome acute respiratory syndrome coronavirus antiviral activities antiviral drug antiviral drugs average mortality clinical trial Combination confirmed COVID-19 patients control group control groups coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients database databases discharge discharge rate early administration Google Scholar Hospitalization Host IFN IFN-β IFNs impairing innate immune system interferon Interferon-β interferons interferons (IFNs Intervention intervention group Meta-analysis Mortality offer outcome primary and secondary outcomes protocol randomized clinical trial reported review searched secondary outcome selected severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 standard care systematic review the interferon the median therapeutic strategy Type type I interferons unique [DOI] 10.1007/s00210-021-02061-x PMC 바로가기 [Article Type] Meta-Analysis
An open-label randomized controlled trial evaluating the efficacy of chloroquine/hydroxychloroquine in severe COVID-19 patients중증 COVID-19 환자에서 클로로퀸/하이드록시클로로퀸의 효능을 평가하는 공개 라벨 무작위 대조 시험Clinical Trial Published on 2021-04-272022-08-13 Journal: Scientific Reports [Category] MERS, SARS, 임상, 치료제, [키워드] 105 patient 105 patients 9-point ordinal scale acute renal dysfunction acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 added Administered all-cause mortality analyzed arrythmia Arrythmias Brazil cardiovascular complication cardiovascular complications Chloroquine chloroquine/hydroxychloroquine Clinical outcome clinical status Combination coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 doubt drugs Effect Effects Efficacy enrolled evaluate FIVE Follow-up form hospital Hydroxychloroquine incidence increased risk intention to treat intervention group Invasive mechanical ventilation KDIGO mITT Odds ratio once daily Open-label Ordinal Scale outcomes Patient patients hospitalized positive RT-PCR Primary outcome randomization Randomized Randomized controlled trial Registered renal dysfunction respiratory risk risk ratio Sample size SARS-CoV-2 secondary outcome severe acute respiratory syndrome Coronavirus severe COVID-19 severe COVID-19 patient severe renal dysfunction standard care standard treatment the disease Treatment Trial Trial registration were assessed worsening [DOI] 10.1038/s41598-021-88509-9 PMC 바로가기 [Article Type] Clinical Trial
Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19코비드-19에 걸린 중환자의 인터루킨-6 수용체 길항제Randomized Controlled Trial Published on 2021-04-222022-09-12 Journal: The New England Journal of Medicine [Category] Fulltext, MERS, 임상, 진단, [키워드] 24 hour Adaptive platform trial adjusted Adult patient Analysis antagonist antagonists assigned Bayesian control group coronavirus disease criteria Critically ill patient cumulative odds ratio Efficacy evaluated greater groups hazard ratio ICU ICUs Ill In-hospital death intensive care interleukin-6 receptor International interquartile range median multifactorial Odds ratio organ organ support outcomes Patient posterior probability Primary outcome Randomly receive receiving REMAP-CAP sarilumab secondary analysis standard care statistical model supported survival Tocilizumab Treatment Trial yielding [DOI] 10.1056/NEJMoa2100433 PMC 바로가기 [Article Type] Randomized Controlled Trial
Safety profile of enhanced thromboprophylaxis strategies for critically ill COVID-19 patients during the first wave of the pandemic: observational report from 28 European intensive care unitsObservational Study Published on 2021-04-222022-10-04 Journal: Critical Care [Category] MERS, 임상, [키워드] age Analysis anticoagulation anticoagulation treatment association bleeding body mass index clinical Clinical characteristics Clinical outcome Cohort Complication complications concern COVID COVID-19 COVID-19 patient COVID-19 patients Critical Critical illness Critically ill Critically ill patient defined demographics discharge Effect European event First wave Guidance heparin ICU ICUs increased risk Intensive care medicine intensive care unit Linear model log male Mortality multivariable occurred outcome outcomes pandemic Patient patients potential risk Prevalence Prophylaxis protocol raised receiving red blood cell reduced reduction in reported Result Safe Safety SARS-COV-2 infection standard care standard thromboprophylaxis supplementary material therapeutic anticoagulation Thromboembolic event Thromboembolic events Thromboprophylaxis thrombosis Trial was collected was used [DOI] 10.1186/s13054-021-03543-3 PMC 바로가기 [Article Type] Observational Study
Therapeutic respiratory and functional rehabilitation protocol for intensive care unit patients affected by COVID-19: a structured summary of a study protocol for a randomised controlled trialCOVID-19의 영향을 받는 중환자실 환자를 위한 치료 호흡 및 기능 재활 프로토콜: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2021-04-122022-09-10 Journal: Trials [Category] MERS, 임상, [키워드] 1:1 6-minute walk test activities activity Admission Adult patients affected age Agitation approved assessment balanced randomization blinded Blinding block blocks Borg both groups Care clinical status clinical trial Coma Comorbidities Comorbidity comparator conducted confidentiality cooperation COVID-19 criteria Critical Critical illness daily living Data collection defined discharge dissemination distribution of patient double-blind Douro Dyspnea Effect element eligible Endpoint evaluate evaluated evaluator exertion expected Follow-up for inclusion form functional functional capacity functional rehabilitation Glasgow coma scale group Handgrip strength test Health Health Service Health services Hospital stay Hospitalization Hospitalized hospitalized COVID-19 patients ICU incidence include independent intensive care intensive care unit Intervention intervention group life mechanical ventilation Medical Research Council Medicine Mobility Monday need for oxygen number Nurse nursing care objective occupational therapy occur outcome outcome measure outcomes oxygen Oxygen therapy participant Participants Patient per day Perceived physical Physical assessment physical rehabilitation Physiotherapist Physiotherapy Portugal positioning post-intensive care syndrome Potential Potential participants primary outcome measure progression protocol Quality of life question randomisation randomised randomised controlled trial randomization sequence Randomized Randomized controlled trial readmission reassurance receive recommendation recorded recruited referred to Registered registry rehabilitation rehabilitation exercises rehabilitation medicine respiratory respiratory insufficiency respiratory rehabilitation Respiratory system responsible Sample size Saturday scale Secondary objectives sequence Sex Society stability standard care Standard of care status strength test study group Study protocol subject suctioning supplementary material survey survival Test the patient therapy Tolerance treated Treatment Trial registration two groups verbal website [DOI] 10.1186/s13063-021-05210-y PMC 바로가기 [Article Type] Letter