Impact of COVID-19 pandemic on oncology clinical trial design, data collection and analysisCOVID-19 전염병이 종양학 임상 시험 설계, 데이터 수집 및 분석에 미치는 영향Article Published on 2022-05-012022-09-11 Journal: Contemporary clinical trials [Category] 임상, [키워드] Affect analyses Analysis ARMS assessment assessments clinical trial Clinical trial design clinical trials COVID-19 COVID-19 pandemic Data collection Data monitoring committee Decision tree disease Endpoint endpoints enrolled evaluate evaluated identify Impact impacted intent-to-treat missingness oncology overall survival Patient proportion proportions randomized trial recommendations regions robustness Simulation Sponsor statistical statistical inference Study design survival treat Treatment treatment arm Treatment effect size Trial Trial design trials [DOI] 10.1016/j.cct.2022.106736 PMC 바로가기 [Article Type] Article
Statistical Modeling for Quality Risk Assessment of Clinical Trials: Follow-Up at the Era of Remote Auditing임상 시험의 품질 위험 평가를 위한 통계 모델링: 원격 감사 시대의 후속 조치Article Published on 2022-05-012022-09-11 Journal: Therapeutic innovation & regulatory science [Category] 임상, [키워드] activity Advanced analytics assessment Audit can be used categories clinical clinical impact clinical trial clinical trials complement conducted Consent continuous surveillance COVID-19 pandemic data integrity endpoints estimate facilitate Factor Good Clinical Practice Good clinical practice (GCP) help identify impact factor integrity investigator Logistic regression methodology modeling predict Protecting Quality Quality assurance Quality monitoring remote Reporting resulting risk risk factor Safety statistical Statistical modeling target [DOI] 10.1007/s43441-022-00388-y PMC 바로가기 [Article Type] Article
Impact of COVID-19 on the Patient Enrollment for a Pragmatic, Cluster Randomized Clinical Trial for FibromyalgiaConference abstract Published on 2022-05-012022-10-05 Journal: The Journal of Pain [Category] 임상, [키워드] added addition Analysis assessment center clinical clinical trial clinician clinics Conducting coordinating COVID-19 COVID-19 pandemic decrease ENhance enrolled Enrollment facilitate fibromyalgia greater Healthcare systems heterogeneity Impact impacted IMPROVE in-person visit initiative Interaction nerve NIH Pain pandemic participant Patient Personal protective equipment Pragmatic Primary outcome PROTECT questionnaire required skin social distancing statistical Stimulation Support supported the patient Transcutaneous transitioned Trial [DOI] 10.1016/j.jpain.2022.03.125 [Article Type] Conference abstract
Mental health problems among Dutch adolescents of the general population before and 9 months after the COVID-19 outbreak: A longitudinal cohort studyResearch article Published on 2022-05-012022-10-05 Journal: Psychiatry research [Category] COVID19(2023년), SARS, 변종, [키워드] adolescents Anxiety Cohort cohorts conducted COVID-19 COVID-19 pandemic Depression fatigue General population Health incidence increased the risk longitudinal cohort study mean score Medicine mental health problem mental health service moderate nine not differ outbreak pandemic Prevalence prevalent Probability problem problems Result statistical Symptom [DOI] 10.1016/j.psychres.2022.114528 [Article Type] Research article
Speech as a Biomarker for COVID-19 Detection Using Machine Learning기계 학습을 사용한 COVID-19 탐지를 위한 바이오마커로서의 음성Article Published on 2022-04-182022-09-11 Journal: Computational Intelligence and Neuroscience [Category] 바이오마커, [키워드] Algorithm analyzed best classification algorithm classification algorithms COVID-19 COVID-19 negative decision detection diagnosing distribution evaluation metrics feature fitting forest Fourier transform healthy healthy individuals investigated machine learning Misclassification opposite parameter Physiological changes positive positive individual positive individuals recall shown speech statistical statistical analysis tuning [DOI] 10.1155/2022/6093613 PMC 바로가기 [Article Type] Article
Rational Design of CRISPR/Cas12a-RPA Based One-Pot COVID-19 Detection with Design of Experiments실험 계획을 통한 CRISPR/Cas12a-RPA 기반 One-Pot COVID-19 탐지의 합리적 설계Article Published on 2022-04-152022-09-11 Journal: ACS synthetic biology [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] accelerate addition amplification applied approach benefit buffer complex component components condition COVID-19 COVID-19 pandemic CRISPR CRISPR/Cas12a critical impact definitive screening design demonstrated design of experiments detection Detection sensitivity diagnostic Diagnostic method diagnostics DNA DNA sequence DoE Effect effective experiment Factor full-length SARS-CoV-2 Genome highlight isothermal molecular Molecular diagnosis N gene one-pot COVID-19 testing optimization polymerase reaction reaction optimization Reactions recombinase polymerase amplification recombinase polymerase amplification (RPA). reverse transcription RNA RNase RNase inhibitor robust RPA RT-qPCR sensitivity significant effect significantly simple statistical variables [DOI] 10.1021/acssynbio.1c00617 PMC 바로가기 [Article Type] Article
The Dysregulation of the Renin-Angiotensin System in COVID-19 Studied by Serum Proteomics: Angiotensinogen Increases with Disease Severity혈청 단백질체학으로 연구한 COVID-19에서 레닌-안지오텐신 시스템의 조절장애: 질병의 중증도에 따라 안지오텐시노겐 증가Article Published on 2022-04-122022-09-11 Journal: Molecules [Category] 유전자 메커니즘, [키워드] ACE Activation AGT analyses Analysis angiotensin angiotensinogen bradykinin Cohort complement Complement activation Concentration convalescent coronavirus correlated COVID-19 COVID-19 infection CPN Critically ill critically ill patients disease severity expression expression analysis followed by group healthy probands hospitalized COVID-19 patients hospitalized patient hospitalized patients increase indicated Infection investigated Kallikrein Kallikrein-kinin system KLKB1 KNG1 mass spectrometry pathophysiological pathway patients plasminogen profile Protein protein expression proteomics RAS Renin renin-angiotensin system separated serum Serum protein significantly statistical System was performed [DOI] 10.3390/molecules27082495 PMC 바로가기 [Article Type] Article
Bioinformatics and System Biology Approach to Identify the Influences of COVID-19 on Rheumatoid Arthritis류마티스 관절염에 대한 COVID-19의 영향을 식별하기 위한 생물정보학 및 시스템 생물학 접근Article Published on 2022-04-072022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Analysis approach Arthritis association bioinformatics Biology candidate drug condition coronavirus coronavirus disease Coronavirus disease 2019 COVID COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients dataset datasets DEGs differentially expressed differentially expressed gene Differentially expressed genes drug drug molecule functional functional enrichment generate hub genes identify Infection influence interactions mechanism molecular mechanism molecular mechanisms Mortality ontological Pathway analysis performed potential molecular PPI PPI network progression protein-protein interaction proteinprotein interaction rapid increase Rheumatoid rheumatoid arthritis SARS-CoV-2 screened severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe coronavirus disease statistical System Systems biology targeted therapy Transcription transcription factor Treatment were used [DOI] 10.3389/fimmu.2022.860676 PMC 바로가기 [Article Type] Article
Safety and immunogenicity of a synthetic multiantigen modified vaccinia virus Ankara-based COVID-19 vaccine (COH04S1): an open-label and randomised, phase 1 trial합성 다항원 변형 백시니아 바이러스 앙카라 기반 COVID-19 백신(COH04S1)의 안전성 및 면역원성: 공개 및 무작위 배정, 1상 시험Clinical Trial Published on 2022-04-012022-09-11 Journal: The Lancet. Microbe [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료법, [키워드] 95% CI Administered Adults Analysis Anxiety assigned baseline body-mass body-mass index boost Cellular responses center city Cohort Comprehensive Concentration COVID-19 vaccine development dose drug eight fatigue female Fever Fisher Fisher's exact test FIVE followed by foundation Future GRADE grade 3 Haematology healthy High dose High-dose Hope IgG immunogenicity immunological increase in initiated injection interferon interferon-γ Intramuscular injection less limit low dose low-dose medium dose modified vaccinia virus modified vaccinia virus Ankara Moss negative pregnancy test nine nucleocapsid nucleocapsid antigens nucleocapsid protein nucleocapsid-specific antibody Open-label outcome participant PCR test Phase 1 phase 1 trial Placebo placebo group plaque-forming unit plaque-forming units poxvirus pregnancy test Primary outcome provided randomised Randomly receive Registered reported risk Safety SARS-CoV-2 antibody SARS-CoV-2 neutralising antibodies SARS-CoV-2 neutralising antibody SARS-CoV-2 spike Secondary objectives secondary outcome secreting Seroconversion seroconversion rate seroconversion rates Seven severe adverse event severe adverse events Spike protein statistical T cell T cells T-cell responses titre Tolerability Trial troponin USA vaccination Vaccine Viral viral neutralisation was done was measured was tested [DOI] 10.1016/S2666-5247(22)00027-1 PMC 바로가기 [Article Type] Clinical Trial
Clinical features and independent predictors for recurrence of positive SARS-CoV-2 RNA: A propensity score-matched analysis양성 SARS-CoV-2 RNA의 재발에 대한 임상적 특징 및 독립적 예측인자: 성향 점수 일치 분석Article Published on 2022-04-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 치료제, [키워드] 95% CI 95% confidence interval activated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect Analysis Blood borderline categorical variable CD3 CD4 chlorine clinic clinical confounding factors coronavirus count COVID-19 COVID-19 patient cured determine discharged elevated Factor feature hospital independent independent predictor independent predictors independent risk factor independent risk factors Logistic regression analysis marker multivariate multivariate logistic regression multivariate logistic regression analysis Odds ratio Patient positive Potassium propensity score matching prothrombinase Public recurrence regression analysis RNA SARS-CoV-2 SARS-CoV-2 RNA sensitivity analysis serum severe acute respiratory syndrome Coronavirus statistical statistically significant virus was used with COVID-19 [DOI] 10.1002/jmv.27450 PMC 바로가기 [Article Type] Article