Targeted Mitochondrial Therapy With Over-Expressed MAVS Protein From Mesenchymal Stem Cells: A New Therapeutic Approach for COVID-19Cell and Developmental Biology Published on 2021-06-112022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] ACE2 addition affecting approach cause Cell cellular cellular immunity COVID-19 damaged cell damaged tissue disease Diseases element expression expression of SARS-CoV-2 healthy host cell IFN immune immune response Impaired IMPROVE induce Inflammation innate immune response innate immune responses innate immune system interferon Ligand MAVS mesenchymal stem cell Mitochondria mitochondrial mitochondrial antiviral-signaling protein MSC MSCs New outer membrane pathogenesis of COVID-19 Probability Protein pulmonary involvement reduce regenerative regulate Regulatory rejection Replication S protein SARS-CoV-2 STEM stem cell Stress Symptom the SARS-CoV-2 these cell tissue inflammation transferring Transport viable treatment viral spike protein virus [DOI] 10.3389/fcell.2021.695362 PMC 바로가기 [Article Type] Cell and Developmental Biology
Anticipated impact of stem cell and other cellular medicine clinical trials for COVID-19COVID-19에 대한 줄기 세포 및 기타 세포 의학 임상 시험의 예상 영향Short Communication Published on 2021-06-112022-09-10 Journal: Regenerative Medicine [Category] MERS, SARS, 임상, [키워드] analyzed average Cell Cell therapy cellular cellular medicine clinical trial clinical trials collected COVID-19 criteria Critical defined effective Evidence material MOST MSCs regenerative medicine Safe stem cell Stem cell therapy stem cells therapy Treatment treatments for COVID-19 Trial [DOI] 10.2217/rme-2021-0025 PMC 바로가기 [Article Type] Short Communication
AI-guided discovery of the invariant host response to viral pandemics바이러스 전염병에 대한 불변 숙주 반응의 AI 유도 발견Research Paper Published on 2021-06-112022-09-11 Journal: EBioMedicine [Category] MERS, 바이오마커, 진단, 치료제, [키워드] “cytokine storm” abrogate ACE2 acting analyzed Angiotensin converting enzyme (ACE)-2 Antiviral antiviral agent Apoptosis approach Artificial intelligence/machine learning Boolean equivalent clusters candidate drugs cause cell senescence center clinical conserved Cooperative Coronavirus COVID-19 coronavirus disease Coronavirus disease 2019 COVID-19 cytokine Cytokine storm dataset determine Diego disease severity EIDD-2801 elevated ENCODE entry of SARS-CoV-2 epithelial facilitate fatal COVID-19 fatal disease fatality finding Fund funding hamster Healthcare system High-dose host cells Host immune response host response Human IL15 IL15RA immune response immunologist implicated in viral Interleukin 15 (IL15) knowledge limit limits LJI lung Lung alveoli lung epithelial Lungs myeloid cell myeloid cells natural killer (NK) cells Neutralizing antibodies neutralizing antibody NIH NK cell office over Pandemics paradoxical Patient plasma Plasma levels President Program Quantitative receptor scientist signature STEM stem cell subset supported System therapeutic to define transcriptomic University of California utility Viral virus was used [DOI] 10.1016/j.ebiom.2021.103390 PMC 바로가기 [Article Type] Research Paper
Characteristics and Developments in Mesenchymal Stem Cell Therapy for COVID-19: An UpdateReview Article Published on 2021-06-022022-10-29 Journal: Stem Cells International [Category] COVID-19, [키워드] ACE2 acute respiratory distress acute respiratory syndrome Angiotensin-converting enzyme Anti-inflammatory approaches ARDS caused Cell Characteristics clinical clinical manifestations clinical symptom coronavirus coronavirus disease cough COVID-19 current Cytokine storm development drug Evidence Fever Health help highlight humans immune function include information measure MSC MSC therapy MSCs outbreak pathogenic virus Prevent Providing receptor respiratory tract SARS-CoV-2 shown STEM stem cell syndrome target the disease transmitted treat Treatment virus [DOI] 10.1155/2021/5593584 PMC 바로가기 [Article Type] Review Article
Compassionate mesenchymal stem cell treatment in a severe COVID-19 patient: a case report중증 코로나19 환자의 온정 간엽줄기세포 치료: 증례보고Case Reports Published on 2021-06-012022-09-10 Journal: Croatian Medical Journal [Category] MERS, SARS, 신약개발, [키워드] 49 days acute respiratory distress acute respiratory distress syndrome addition affected Allogeneic Antiviral ARDS attending physicians Bacterial infection Case report Cell Clinical course cold-like symptom cold-like symptoms compassionate use COVID-19 discharged Exhaustion family general condition hospital immunosuppressive intensive care intensive care unit mechanically ventilated Mesenchymal stem cells MSC MSC therapy Patient physician rapid clinical deterioration respiratory distress severe COVID-19 severe symptom severe symptoms Side effect stem cell supportive therapy syndrome therapy Treatment Trial [DOI] 10.3325/cmj.2021.62.288 PMC 바로가기 [Article Type] Case Reports
Exosomes contribution in COVID-19 patients’ treatmentCommentary Published on 2021-05-312022-10-30 Journal: Journal of Translational Medicine [Category] COVID-19, SARS, [키워드] acute respiratory syndrome adipocyte adipose derived stem cells caused Cell clinical study coronavirus coronavirus disease COVID-19 COVID-19 infection COVID-19 patients derivative effective endothelial Exosome Exosomes Factors growth growth factor human diseases immunomodulatory activity Inflammation insulin Mesenchymal stem cells morbidity and mortality MSC MSCs NGF patient safety potential therapeutic agent public health recent SARS-CoV-2 secretion stem cell the patient therapeutic option therapeutic potential therapy Treatment Vascular VEGF [DOI] 10.1186/s12967-021-02884-5 PMC 바로가기 [Article Type] Commentary
Advances in mesenchymal stem cell therapy for immune and inflammatory diseases: Use of cell‐free products and human pluripotent stem cell‐derived mesenchymal stem cellsMesenchymal Stem Cells Published on 2021-05-192022-10-28 Journal: Stem cells translational medicine [Category] Coronavirus, SARS, [키워드] addition advance Allogeneic Autoimmune diseases autologous Cell clinical trial clinical trials COVID‐19 demonstrated Efficacy Endpoint Evidence Exosome Exosomes Extracellular vesicles graft rejection Human human pluripotent stem cells immune Immune cell immunomodulatory property Increasing indication Inflammatory inflammatory disease inflammatory disorders liver Liver cirrhosis mesenchymal stem cell mesenchymal stem/stromal cell therapy MSC MSCs organ transplantation Osteoarthritis outcome prevalent pulmonary disease pulmonary inflammation rejection stem cell Stem cell therapy supported therapeutic therapeutic use therapy tissue Trial while [DOI] 10.1002/sctm.21-0021 PMC 바로가기 [Article Type] Mesenchymal Stem Cells
Treatment of COVID-19 by stage: any space left for mesenchymal stem cell therapy?코로나19 단계별 치료, 중간엽줄기세포 치료 여지는?Review Published on 2021-05-142022-09-10 Journal: Regenerative Medicine [Category] SARS, 임상, [키워드] acute respiratory distress syndrome approach Cell Cell therapy China Controlled trial controlled trials coronavirus COVID-19 Cytokine storm death develop disease severity Diseases Efficacy effort epithelial cells focus immune immune response Infection Inflammation Inflammatory inhibit mesenchymal stem cell Mesenchymal stem cells Numerous Organ failure Pandemics Patient Premature Prevent protocol Result SARS-CoV-2 entry severe COVID-19 severity shown stem cell Stem cell therapy the cell the disease therapeutic therapy Treatment Trial USA vascular cells Viral [DOI] 10.2217/rme-2020-0189 PMC 바로가기 [Article Type] Review
Maternal respiratory SARS-CoV-2 infection in pregnancy is associated with a robust inflammatory response at the maternal-fetal interface임신 중 산모 호흡기 SARS-CoV-2 감염은 산모-태아 경계면에서 강력한 염증 반응과 관련이 있습니다Article Published on 2021-05-142022-09-11 Journal: Med (New York, N.Y.) [Category] MERS, SARS, 유전자 메커니즘, 임상, 진단, 치료기술, [키워드] absence ACE2 ACE2 expression Activation acute respiratory syndrome acute respiratory syndrome coronavirus Analysis analyzed Cell cells center Complication coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 detectable early pregnancy exhibited full term Genes had no healthy histology Hofbauer cells immortalized cell line immortalized cell lines immune immune activation immune mechanism immune responses immunohistochemistry in vitro in vivo increased expression increased risk Infection Inflammatory response Local majority marker Maternal morbidity natural killer NIH outcome pathophysiology performed Placenta placental Placentas precursor precursors preeclampsia Pregnancy pregnancy complications pregnant women PROTECT respiratory robust SARS-CoV-2 SARS-COV-2 infection shielding single-cell stem cell stem cells Support T cells transcriptomics Viral viral infection viral invasion Viral RNA women [DOI] 10.1016/j.medj.2021.04.016 PMC 바로가기 [Article Type] Article
Stem cell therapies and benefaction of somatic cell nuclear transfer cloning in COVID-19 era코로나19 시대의 줄기세포 치료제와 체세포 핵이식 복제의 장점Review Published on 2021-05-122022-09-12 Journal: Stem Cell Research & Therapy [Category] SARS, 진단, [키워드] acute respiratory distress acute respiratory distress syndrome Anti-inflammatory antivirals ARDS being benefit Bio-pharming boost caused Cell cell type Cell-based therapy cellular Clinical studies cloned COVID-19 COVID-19 patient COVID-19 patients damage dependence develop Drug testing Embryo embryonic embryos generate Genome reprogramming Health health emergency immunomodulatory effect immunomodulatory effects Interaction mesenchymal stem cell Mesenchymal stem cells MSC MSCs nuclear organ Organoid organoids potential benefit potential benefits prominence regenerative regenerative medicine Research respiratory distress Respiratory distress syndrome SARS-CoV-2 SARS-COV-2 infection SCNT somatic cell STEM stem cell stem cells structures syndrome therapeutic Therapies therapy transfer transgenic treat unique Vaccinations Vascular [DOI] 10.1186/s13287-021-02334-5 PMC 바로가기 [Article Type] Review