Relationship of Problematic Smartphone Use, Sleep Quality, and Daytime Fatigue Among Quarantined Medical Students During the COVID-19 PandemicPsychiatry Published on 2021-11-102022-10-31 Journal: Frontiers in Psychiatry [Category] COVID-19, [키워드] 95%CI accounted Addiction addition AIS association Athens Insomnia Scale Beijing conducted COVID-19 COVID-19 pandemic daytime examined fatigue female Health Health status hospital information mediating effect Mental multiple regression model participant physical positive correlation problematic smartphone use problems psychological symptom Quality relationship scale Significant significantly Sleep Sleep disturbance sleep quality Smartphone Spearman correlation coefficient structures student Subjective total effect Version were used [DOI] 10.3389/fpsyt.2021.755059 PMC 바로가기 [Article Type] Psychiatry
Anatomical structures, cell types and biomarkers of the Human Reference Atlas Reviews Published on 2021-11-082022-10-05 Journal: Nature cell biology [Category] 바이오마커, [키워드] anatomical Anatomy Atla Biomarker Biomedical research Cell cell type cell types Clinical practice consortia example HRA Human International reference structures utility [DOI] 10.1038/s41556-021-00788-6 [Article Type] Reviews
Factors influencing access and utilization of health services among older people during the COVID − 19 pandemic: a scoping reviewResearch Published on 2021-11-072022-10-27 Journal: Archives of Public Health [Category] COVID-19, [키워드] access affecting Analysis article articles Care conducted contributing to COVID COVID-19 COVID-19 pandemic database determinant elderly eligibility criteria Evidence Factor Health Health Service healthcare healthcare service healthcare services India initial Intervention majority mental health services Older pandemic Result searched social determinants structures supplementary material the United State thematic analysis utilization was performed was used Web of Science were used [DOI] 10.1186/s13690-021-00719-9 PMC 바로가기 [Article Type] Research
In silico binding profile characterization of SARS-CoV-2 spike protein and its mutants bound to human ACE2 receptorSARS-CoV-2 스파이크 단백질 및 인간 ACE2 수용체에 결합된 돌연변이체의 인 실리코(in silico) 결합 프로필 특성화Article Published on 2021-11-052022-09-11 Journal: Briefings in Bioinformatics [Category] MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus affected approach binding binding affinities binding affinity binding free energies binding free energy complexes coronavirus country COVID-19 decomposition domain drug resistance free energies free energy Free energy calculation and decomposition Free energy calculations G476S hACE2 hACE2 protein hotspot Hotspot residues human ACE2 human ACE2 receptor infect interfere investigated MD simulation molecular molecular dynamics Molecular mechanics mutant nine Novel coronavirus pandemic Poisson Protein–protein interaction protocol prototype provide RBD RBD mutations RBDs receptor Receptor-binding domain respiratory SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 Spike RBD severe acute respiratory syndrome Coronavirus small molecule small molecule drug small molecule drugs spike spike glycoprotein Spike RBD/hACE2. Structure structures surface area V367F V483A Vaccine virus [DOI] 10.1093/bib/bbab188 PMC 바로가기 [Article Type] Article
Improving sampling of crystallographic disorder in ensemble refinementCcp4 Published on 2021-11-012022-10-27 Journal: Acta crystallographica. Section D [Category] Coronavirus, SARS, [키워드] Affect approach component conformation conformational demonstrated described disorder disorder modelling effective ensemble refinement heterogeneity improvement Improving inherent Local macromolecular macromolecule molecular molecular dynamics physically protease robust shown strained Structure structure refinement structures the SARS-CoV-2 utility [DOI] 10.1107/S2059798321010044 PMC 바로가기 [Article Type] Ccp4
Preparedness and response to covid-19 in Woreta Town, North West EthiopiaResearch article Published on 2021-11-012022-10-05 Journal: Scientific African [Category] 신약개발, [키워드] adopted adverse impact Analysis approach collected Community conducted country COVID-19 COVID-19 vaccines declining develop early response effort Ethiopia Government Health Health care worker health worker implementation less Local measure mechanisms North outcomes pandemic preparedness preventive measure response risk South-Gondar structures the disease town transfer well were used West Woreta [DOI] 10.1016/j.sciaf.2021.e01037 [Article Type] Research article
virusMED: an atlas of hotspots of viral proteinsResearch Papers Published on 2021-11-012022-10-29 Journal: IUCrJ [Category] COVID-19, [키워드] antigen epitope antiviral drugs atomic binding binding site characterized Critical database drug DrugBank Epitopes FDA-approved drugs functional Google Map HIV-1 hosts hotspot in viral Influenza Interaction metal metal ions Protein Research SARS-CoV-2 viruses specific antibody Strains structures therapeutic agent valuable resource viral infections viral metal proteins Viral protein viral protein structures Viral proteins virus virus hotspots virus strain virusMED database [DOI] 10.1107/S2052252521009076 PMC 바로가기 [Article Type] Research Papers
Early detection of change patterns in COVID-19 incidence and the implementation of public health policies: A multi-national studyResearch article Published on 2021-11-012022-10-05 Journal: Public Health in Practice [Category] 치료기술, [키워드] Algorithm Americas appear approach B-spline B-spline trend fitting and prediction Bayesian caused Change point models changes in Confidence intervals correlated country COVID-19 COVID-19 case COVID-19 disease COVID-19 incidence COVID-19 pandemic disease Early detection effective effort Europe European Evidence examined Express extension genomic data global pandemic Health policy heterogeneous identify implementation incidence Incidences indicated management National objective observational study P-value pandemic posterior probability predicted Prevalence Prevent public health regions Regression model Research response Result SARS-CoV-2 coronavirus Social distancing measure spread of COVID-19 statistical statistically structures the mean translated union West WHO widespread World Health Organization [DOI] 10.1016/j.puhip.2020.100064 [Article Type] Research article
PTSD as an Endothelial Disease: Insights From COVID-19Neuroscience Published on 2021-10-292022-10-31 Journal: Frontiers in Cellular Neuroscience [Category] COVID-19, [키워드] activate affected ANG angiotensin receptor blocker Antigen BDNF Brain cell types cleaving conditions COVID-19 Critical disorder disorders disrupt dysfunction Effect endothelia Endothelial cell endothelial cells enzyme fibrinolytic system furin Host individuals inhibitor inhibitors insight Lactate microvascular permeability Mitochondria mitochondrial molecular NSP6 Orf9b pandemic Pathogenesis pathology Pathways populations Posttraumatic Stress potential treatments Premature Prevalence Psychological PTSD receptor renin-angiotensin system S2 antigen SARS-CoV-2 SARS-CoV-2 virus senescent Stress structures supported survivor susceptibility the SARS-CoV-2 virus therapy trauma Trigger upregulate virus [DOI] 10.3389/fncel.2021.770387 PMC 바로가기 [Article Type] Neuroscience
Design of functionalised circular tandem repeat proteins with longer repeat topologies and enhanced subunit contact surfacesArticle Published on 2021-10-292022-10-31 Journal: Communications Biology [Category] COVID-19, MERS, SARS, [키워드] binding affinity Circular Contact de novo demonstrated domain domains inefficient Interaction motif Nanobiotechnology Particle Protein protein sequence Proteins Receptor binding domain repeated SARS CoV-2 significantly stability structures subunit subunits Topology trimeric viral neutralization X-ray crystallography [DOI] 10.1038/s42003-021-02766-y PMC 바로가기 [Article Type] Article