Stable trimer formation of spike protein from porcine epidemic diarrhea virus improves the efficiency of secretory production in silkworms and induces neutralizing antibodies in miceResearch Article Published on 2021-07-072022-10-28 Journal: Veterinary Research [Category] Coronavirus, [키워드] cause contributing to coronavirus demonstrated diarrhea economic loss Efficiency elicit epidemic diarrhea evaluated expression expression vector Genetic high mortality rate homotrimer host cell Humoral immunity IgG immunization IMPROVE induce Infection intrinsically less mice motif mouse Neonatal neutralizing antibody pathogen PEDV platform Porcine epidemic diarrhea virus PROTECT protective effect Protein provide S protein S proteins sera serum Silkworm-baculovirus expression vector system Spike protein STABLE strain Subunit vaccine supplementary material the S protein trimer trimeric trimeric motif Vaccine Vaccine development Vero Cell viral membrane virus watery [DOI] 10.1186/s13567-021-00971-5 PMC 바로가기 [Article Type] Research Article
Immunogenicity Studies of Plant-Produced SARS-CoV-2 Receptor Binding Domain-Based Subunit Vaccine Candidate with Different Adjuvant FormulationsArticle Published on 2021-07-052022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] addition adjuvant adjuvants aluminum Antibody Response candidate Cell Cellular immune response clinical trials coronavirus disease COVID-19 demonstrated domain effective vaccine Efficacy and safety elicited evaluated Formulation Frequency fused gel groups Head-to-head comparison hydroxide IgG IgG1 IgG2a Immune profile immune response immunogenicity MF59 mice Neutralizing antibodies neutralizing antibody no significant difference performed plant-based vaccine problem public health RBD RBD-Fc Receptor-binding domain Research responses Salmonella SARS-CoV-2 significantly increased subtype Subunit vaccine subunit vaccines tested Transmission vaccination Vaccine virus spread [DOI] 10.3390/vaccines9070744 PMC 바로가기 [Article Type] Article
The impact of spike mutated variants of SARS-CoV2 [Alpha, Beta, Gamma, Delta, and Lambda] on the efficacy of subunit recombinant vaccinesSARS-CoV2[알파, 베타, 감마, 델타 및 람다]의 스파이크 돌연변이 변이체가 소단위 재조합 백신의 효능에 미치는 영향Review Published on 2021-07-012022-09-11 Journal: The Brazilian journal of infectious diseases : an [Category] SARS, 변종, 진단, [키워드] (alpha (Alpha) (Beta ACE2 Alpha alpha and delta variants Alpha variant Analysis angiotensin Angiotensin-converting enzyme antibody Antigen B.1.1.7 B.1.351 B.1.617 Beta bind binding COVID-19 Delta delta variant described Efficacy elicited focus Gamma greater host cell human infection humans immune response immunization infection process Invasion Lambda mutated variant mutated variants Mutation neutralize Prevent Protein RBD receptor Receptor binding domain recombinant vaccine recombinant vaccines reported robust SARS-CoV-2 SARS-CoV-2 variants SARS-CoV2 specific antibodies specific antibody spike Spike protein subunit subunit protein vaccine Subunit vaccine subunit vaccines Vaccine Vaccine development vaccine efficacy variant variants variants of SARS-CoV-2 virus [DOI] 10.1016/j.bjid.2021.101606 PMC 바로가기 [Article Type] Review
Delivery Routes for COVID-19 VaccinesReview Published on 2021-05-192022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] cause COVID-19 COVID-19 vaccine COVID-19 vaccines deaths delivery determine effective Efficacy Future Immunity IMPROVE inactivated include infections intramuscular intramuscular vaccination intranasal lack local immune response mechanism mucosal mucosal vaccine Novel coronavirus nucleic acid pandemic Pathogens platform Prevent Research route Safe SARS-CoV-2 Spread Subunit vaccine underlie vaccination Vaccinations Vaccine vaccine candidate Vaccines Viral vector vaccines [DOI] 10.3390/vaccines9050524 PMC 바로가기 [Article Type] Review
Clonal analysis of immunodominance and cross-reactivity of the CD4 T cell response to SARS-CoV-2SARS-CoV-2에 대한 CD4 T 세포 반응의 면역우세 및 교차 반응성의 클론 분석Report Published on 2021-05-182022-09-10 Journal: Science (New York, N.y.) [Category] MERS, SARS, 변종, 치료법, [키워드] CD4 Clonal analysis clone clones conserved Coronaviruses cross-reactive cross-reactivity effector Endemic epitope Epitopes helper HLA-DP HLA-DR identify immunodominance immunodominant individual individuals memory T cells nucleoprotein processed robust S protein S proteins SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variants Subunit vaccine subunit vaccines T cell T cell epitope T cell epitopes T cell response T cells the RBD Vaccination strategies Vaccination strategy [DOI] 10.1126/science.abg8985 PMC 바로가기 [Article Type] Report
Plant-Produced Receptor-Binding Domain of SARS-CoV-2 Elicits Potent Neutralizing Responses in Mice and Non-human PrimatesPlant Science Published on 2021-05-132022-10-31 Journal: Frontiers in Plant Science [Category] COVID-19, [키워드] acute respiratory syndrome administration affected affinity column approved caused clinical trials coronavirus coronavirus disease COVID-19 demonstrated domain effective elicited enzyme-linked immunospot assay expressed Fc fragment Fc fusion protein fused global public health human IgG1 IFN-γ immune response immunized mice intramuscular investigated knowledge mice neutralization titer Nicotiana benthamiana Non-human non-human primates plant-produced recombinant protein potent primate Protein protein A purified RBD RBD of SARS-CoV-2 RBD-Fc RBD-Fc fusion protein Receptor-binding domain response SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 RBD protein spreads Stage subunit Subunit vaccine the disease Vaccine vaccine candidate [DOI] 10.3389/fpls.2021.682953 PMC 바로가기 [Article Type] Plant Science
Mice Immunized with the Vaccine Candidate HexaPro Spike Produce Neutralizing Antibodies against SARS-CoV-2Communication Published on 2021-05-122022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] aluminum Antigen candidate collected comparable COVID-19 vaccine equity feasibility Genetic variation HexaPro high-titer neutralizing antibody hydroxide immunization immunized Infection initial live SARS-CoV-2 mice neutralization activity offer physical prefusion prime-boost regimen Produce produced raising RBD receiving recombinant reported S-2P Safe SARS-CoV-2 sera shown spike spike trimer spike trimers subunit Subunit vaccine the receptor-binding domain the SARS-CoV-2 the spike protein Vaccine [DOI] 10.3390/vaccines9050498 PMC 바로가기 [Article Type] Communication
SARS-CoV-2 vaccines: a triumph of science and collaborationSARS-CoV-2 백신: 과학과 협력의 승리Review Published on 2021-05-102022-09-10 Journal: JCI Insight [Category] SARS, 변종, 임상, [키워드] altruism clinical trial clinical trials COVID-19 demonstrated distribution Effectiveness Efficacy Emergency use evade Evidence harmonization Immunity less mRNA mRNA vaccine open overcome Phase III clinical trials protein subunit vaccine reduction in risk S-protein safety profile SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants Sequencing severe COVID-19 Side effect Study participants Subunit vaccine Surface glycoprotein symptomatic symptomatic COVID-19 vaccination against COVID-19 Vaccine Vaccines Viral Viral vector [DOI] 10.1172/jci.insight.149187 PMC 바로가기 [Article Type] Review
Hemagglutinin Functionalized Liposomal Vaccines Enhance Germinal Center and Follicular Helper T Cell Immunity헤마글루티닌 기능화 리포솜 백신은 배아 중심 및 여포 도우미 T 세포 면역을 강화합니다Article Published on 2021-05-012022-09-12 Journal: Advanced Healthcare Materials [Category] SARS, 진단, [키워드] Antigen B cell center draining lymph nodes driving effective vaccine elicit follicular follicular helper T cells Germinal Germinal center germinal centers helper helper T cell hemagglutinin highly pathogenic HIV immunization immunogen Influenza influenza vaccines Influenza virus life-threatening Liposome liposomes mice microfluidic mixers nanoparticle-based vaccines. pathogen Protective Protein provide public health reported responses Safe SARS-CoV-2 serum antibody Subunit vaccine subunit vaccines Toxicity Vaccine Vaccines virus [DOI] 10.1002/adhm.202002142 PMC 바로가기 [Article Type] Article
Multifunctional Immunoadjuvants for Use in Minimalist Nucleic Acid VaccinesReview Published on 2021-05-012024-09-02 Journal: Pharmaceutics [Category] 대상포진, [키워드] adjuvant mRNA nonviral vaccine pDNA Subunit vaccine [DOI] 10.3390/pharmaceutics13050644 PMC 바로가기 [Article Type] Review