Immune Profile and Clinical Outcome of Breakthrough Cases After Vaccination With an Inactivated SARS-CoV-2 Vaccine비활성화된 SARS-CoV-2 백신 접종 후 면역 프로필 및 돌발 사례의 임상 결과Clinical Trial Published on 2021-09-292022-09-12 Journal: Frontiers in Immunology [Category] SARS, 임상, 진단, [키워드] acute respiratory syndrome analyzed approved breakthrough cases carried circulating clinical clinical trial Comorbidities constant CoronaVac coronavirus CoV COVID-19 defined disease Effectiveness Efficacy effort Emergency use exhibited Factors IgG IgG antibody immune response immunization immunological profile inactivated increase in Infection information interferon-γ-secreting T cell lack mechanical ventilation Mild moderate neutralizing capacity nine occur phase 3 clinical trial Prevent profile reduce reported required risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine second dose Seven severe disease significant increase subjects symptomatic cases symptomatic infection symptomatic SARS-CoV-2 infection symptoms onset vaccination vaccination schedule Vaccine Vaccine-induced immunity Vaccines [DOI] 10.3389/fimmu.2021.742914 PMC 바로가기 [Article Type] Clinical Trial
MHC Variants Associated With Symptomatic Versus Asymptomatic SARS-CoV-2 Infection in Highly Exposed Individuals고도로 노출된 개인의 무증상 SARS-CoV-2 감염 대 무증상 SARS-CoV-2 감염과 관련된 MHC 변이Immunology Published on 2021-09-282022-09-11 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age allele analyzed antigen-presentation association Asymptomatic Combination comparable contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytotoxic activity develop downregulating DRB1 DRB1*04:01 Epigenetic explained expression Factor Factors followed by Genetic genetic factors Genotype genotypes Haplotype haplotypes histocompatibility complex HLA HLA-A HLA-DRB1 identify immune modulation immune response immunological individual individuals infected individual infected individuals Infection involved low expression major histocompatibility complex MHC MICA MICB modulate natural killer NK cell one individual partner pathway Quantitative remained residue resistance respiratory SARS-CoV-2 seronegative serum severe acute respiratory syndrome Coronavirus susceptibility Symptom symptomatic symptomatic COVID-19 symptomatic infection symptomatic infections uninfected variant variants whole-exome sequencing women [DOI] 10.3389/fimmu.2021.742881 PMC 바로가기 [Article Type] Immunology
Reduced subgenomic RNA expression is a molecular indicator of asymptomatic SARS-CoV-2 infection Research Published on 2021-09-222022-10-05 Journal: Communications Medicine [Category] 유전자 메커니즘, 진단, 치료제, [키워드] absence acute respiratory syndrome Analysis Asymptomatic asymptomatic infections asymptomatic patient caused changes in Clinical severity collected conducted coronavirus correlated correlation defined Deletion disease disease severity effort expression Genetic variant genomic host responses hosts identify in viral individual induce Infection less mechanism molecular mutational burden observé quasispecy repressed Result RNA expression RNA viruses RNAs robust SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-COV-2 infection SARS-CoV-2 proteome sgRNA significantly single nucleotide specimen Structural variant symptomatic and asymptomatic symptomatic individuals symptomatic infection Symptoms transcript transcriptomic treatment responses unique Vaccine development variant Variation virulence virus while widespread [DOI] 10.1038/s43856-021-00034-y [Article Type] Research
Prevention of SARS-CoV-2 (COVID-19) transmission in residential aged care using ultraviolet light (PETRA): a two-arm crossover randomised controlled trial protocol자외선 (PETRA)을 사용한 주거 노화 치료에서 SARS-COV-2 (COVID-19) 전송 예방 : 2ARM 크로스 오버 무작위 대조 시험 프로토콜Study Protocol Published on 2021-09-172022-09-10 Journal: BMC Infectious Diseases [Category] SARS, 임상, 치료기술, [키워드] addition adjunct baseline benefit Care care providers changes in Characteristics clinical Complication conducted Contact contribute Controlled trial correlation COVID-19 COVID-19 outbreak crossover detect determine droplet transmission effective Efficacy Evidence facility focus followed by genomic germicidal Germicidal ultraviolet light hand hygiene Health care quality hospitalisation hygiene incidence rate incidence rates include Infection infection control infection rate initial Intervention Laboratory measure Measures morbidity and mortality Mortality multicentre New Other respiratory viruses outcome partnership pathogen transmission Prevent prevention Primary outcome protocol randomised randomised controlled trial rate ratio reduce reducing reduction in Registered registry Residential aged care respiratory Respiratory illness respiratory illnesses respiratory infection respiratory infections respiratory viral respiratory virus Respiratory virus infection respiratory viruses risk Sample size SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 transmission secondary Secondary outcomes separated severe disease social distancing South Spread symptomatic symptomatic infection Transmission transmission of SARS-CoV-2 Two-arm ultraviolet ultraviolet light Viral vulnerable population zone [DOI] 10.1186/s12879-021-06659-7 PMC 바로가기 [Article Type] Study Protocol
Modelling COVID-19 severity in the Republic of Ireland using patient co-morbidities, socioeconomic profile and geographic location, February to November 2020Article Published on 2021-09-162022-10-29 Journal: Scientific Reports [Category] COVID-19, [키워드] 95% CI Admission admitted to ICU age approach co-morbidities conditions COVID-19 COVID-19 infection COVID-19 progression COVID-19 severity death demonstrated diagnoses died Diseases form Gender geographic location Health Health care hospitalisation Hospitalization ICU ICU admission ICU treatment incidence increased risk increasingly intensive care Ireland laboratory-confirmed Linear model Model Mortality National obese patient outcome Patient patient triage predictor prognostic progression receive required retrospective cohort study risk factor Risk factors Severe obesity Surveillance symptomatic symptomatic infection understanding urban vaccination were used [DOI] 10.1038/s41598-021-98008-6 PMC 바로가기 [Article Type] Article
Management and short-term outcomes of neonates born to mothers with active perinatal SARS-CoV-2 infectionResearch Published on 2021-09-132022-10-28 Journal: BMC Pediatrics [Category] COVID-19, SARS, [키워드] age Asymptomatic database eligible enrolled Evidence febrile illness Follow-up Hospitalization In-hospital Infant management mother Neonate objective outcome positive Prospective Study remained reported Result risk SARS-CoV-2 SARS-COV-2 infection Support symptomatic infection symptoms of infection tested Transmission transmission of SARS-CoV-2 [DOI] 10.1186/s12887-021-02872-0 PMC 바로가기 [Article Type] Research
Asymptomatic or mild symptomatic SARS-CoV-2 infection elicits durable neutralizing antibody responses in children and adolescents무증상 또는 경증의 증상이 있는 SARS-CoV-2 감염은 소아 및 청소년에서 지속적인 중화 항체 반응을 유발합니다Research Article Published on 2021-09-082022-09-10 Journal: JCI Insight [Category] SARS, 진단, 치료기술, [키워드] acute infection Adaptive immunity All participants Antibody Response Antibody responses Asymptomatic children comparable contribute detectable elicit evaluated generate humoral immune response humoral immune responses IgA IgG IgM immune response immune responses immunology Infectious disease Mild Neutralizing activity Neutralizing antibody response Participants populations question Reinfection robust SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-COV-2 infection sera Spread strength symptomatic infection symptomatic SARS-CoV-2 infection virus-neutralizing [DOI] 10.1172/jci.insight.150909 PMC 바로가기 [Article Type] Research Article
Effectiveness of BNT162b2 and mRNA-1273 covid-19 vaccines against symptomatic SARS-CoV-2 infection and severe covid-19 outcomes in Ontario, Canada: test negative design studyBNT162B2 및 mRNA-1273 증상 SARS-COV-2 감염에 대한 COVID-19 백신의 효과 및 캐나다 온타리오 주 온타리오의 심각한 COVID-19 결과 : 테스트 부정적인 설계 연구Research Published on 2021-08-202022-09-10 Journal: The BMJ [Category] MERS, SARS, 변종, 진단, [키워드] 95% confidence interval adjusted BNT162b2 Canada Chain Reaction Clinical characteristics Community comparable death died dose doses E484K E484K mutation effective Effectiveness estimate first dose hospital Hospital admission Hospital admissions interval intervals Logistic regression Moderna mRNA mRNA COVID-19 vaccines mRNA-1273 multivariable logistic regression objective of BNT162b2 Older Older adults outcome outcome measure outcomes participant people with symptoms Pfizer-BioNTech polymerase chain polymerase chain reaction positive Result reverse transcription reverse transcription polymerase chain reaction RT-PCR SARS-CoV-2 SARS-COV-2 infection setting Symptom symptomatic infection symptomatic SARS-CoV-2 infection Test test negative tested Vaccine variant variants younger people [DOI] 10.1136/bmj.n1943 PMC 바로가기 [Article Type] Research
Detection of Anti-SARS-CoV-2-S2 IgG Is More Sensitive Than Anti-RBD IgG in Identifying Asymptomatic COVID-19 PatientsImmunology Published on 2021-08-192022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] addition anti-RBD anti-S2 antibody Antibody detection Antibody Response Antibody titer Asymptomatic asymptomatic infection asymptomatic infections asymptomatic patient asymptomatic patients collected contribute correlation Course COVID-19 COVID-19 patients detection dominant elicit Epidemic evaluated feature FIVE identify identifying IgA IgG IgG antibody IgG level IgM IgM antibody ill patient Immunoglobulin imperative improve diagnostics induce isotype linear Neutralizing antibodies neutralizing antibody nucleic acid plasma sample post infection profile Protein provide RBD response responses S2 protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 transmission SARS-CoV-2-RBD sensitive sensitivity severely ill patients structural proteins symptomatic infection Symptomatic patients the disease the RBD protein [DOI] 10.3389/fimmu.2021.724763 PMC 바로가기 [Article Type] Immunology
Early and High SARS-CoV-2 Neutralizing Antibodies Are Associated with Severity in COVID-19 Patients from India초기 및 높은 SARS-CoV-2 중화 항체는 인도의 COVID-19 환자의 중증도와 관련이 있습니다Article Published on 2021-08-172022-09-12 Journal: The American Journal of Tropical Medicine and Hygi [Category] MERS, SARS, 진단, [키워드] 1:1 association Asymptomatic asymptomatic individual Asymptomatic individuals asymptomatic infection clinical disease Clinical presentations comparable Contact COVID-19 COVID-19 patient defined died disease disease severity examined exhibited fatality females group immune correlates Immunopathogenesis index cases India Live virus male males Mild mild illness mild infections NAb NAb titer NAb titers NAbs neutralization test Neutralizing antibodies neutralizing antibody onset of disease outcome Patient plaque reduction neutralization Plaque reduction neutralization test plasma progression proportion SARS-CoV-2 SARS-COV-2 infection screened Seropositivity serum severe disease severity significantly higher symptomatic infection titers were measured [DOI] 10.4269/ajtmh.21-0014 PMC 바로가기 [Article Type] Article