Employing bioactive compounds derived from Ipomoea obscura (L.) to evaluate potential inhibitor for SARS‐CoV‐2 main protease and ACE2 proteinResearch Article Published on 2020-07-062022-10-31 Journal: Food Frontiers [Category] COVID-19, [키워드] Ipomoea Obscura (L.) ACE2 ACE2 protein ADME Analysis angiotensin converting enzyme Antiviral effect Compound determine evaluate exhibit GC‐MS Genome host cell host cells inhibitor inhibitory activity involved Ipomoea molecular docking Molecular docking study Pro protease Replication Result SARS‐CoV‐2 SARS‐CoV‐2 suggested target protein target proteins viral genome viral replication [DOI] 10.1002/fft2.29 PMC 바로가기 [Article Type] Research Article
Glecaprevir and Maraviroc are high-affinity inhibitors of SARS-CoV-2 main protease: possible implication in COVID-19 therapyBioinformatics Published on 2020-06-262022-10-28 Journal: Bioscience Reports [Category] COVID-19, SARS, [키워드] approach checked clinical manifestations clinical trial Computational methods conserved coronavirus 2 Coronavirus disease 2019 COVID-19 disease drug drug candidate drug design Drug repurposing drug target Effectiveness enzyme Evidence existing pool experimental validation FDA approved Drugs FDA-approved drug glecaprevir inhibitors of SARS-CoV-2 inhibitory interactions lack limitations M pro management Maraviroc molecular docking performed protease provide residue respiratory SARS-CoV-2 target protein the SARS-CoV-2 therapeutic therapeutic option therapy Virtual screening [DOI] 10.1042/BSR20201256 PMC 바로가기 [Article Type] Bioinformatics
Interaction of certain monoterpenoid hydrocarbons with the receptor binding domain of 2019 novel coronavirus (2019-nCoV), transmembrane serine protease 2 (TMPRSS2), cathepsin B, and cathepsin L (CatB/L) and their pharmacokinetic propertiesArticle Published on 2020-06-212022-10-29 Journal: Turkish Journal of Biology [Category] COVID-19, [키워드] 2019 novel coronavirus 2019-nCoV ACE2 addition Analysis binding binding energy cathepsin cathepsin B cathepsin L caused cellular protease coronavirus coronavirus disease COVID-19 cross death docking dose drug-likeness effective evaluated IC50 inhibit Interaction liver cells molecular interaction monoterpene P-glycoprotein pharmacokinetic predicted Receptor binding domain serine protease Spike protein target target protein TMPRSS2 toxic effect transmembrane serine protease [DOI] 10.3906/biy-2005-46 PMC 바로가기 [Article Type] Article
Virtual Screening of Natural Products against Type II Transmembrane Serine Protease (TMPRSS2), the Priming Agent of Coronavirus 2 (SARS-CoV-2)Article Published on 2020-05-122022-10-30 Journal: Molecules [Category] COVID-19, MERS, SARS, [키워드] ACE2 activity acute respiratory syndrome agent angiotensin-converting enzyme 2 approach binding energy block Camostat mesylate caused causes comparable Compound compounds coronavirus coronavirus 2 coronavirus disease COVID-19 death develop distribution docking drug design Environment enzyme facilitate feature greater Host host cells in silico Approach in vitro in vivo Infection inhibitor metabolism molecular molecular docking natural natural product physicochemical product protease Registered residue responsible restrict retained SARS-CoV-2 SARS-CoV-2 pathogenesis screened Screening serine 2 serine protease significant interaction Source Specy Structure target protein the disease three-dimensional structure TMPRSS2 Toxicity transmembrane turn Type viral particle virus were used [DOI] 10.3390/molecules25102271 PMC 바로가기 [Article Type] Article
Molecular docking and dynamics simulation of FDA approved drugs with the main protease from 2019 novel coronavirusResearch Article Published on 2020-03-312022-10-28 Journal: Bioinformation [Category] COVID-19, [키워드] 2019 novel coronavirus 2019-nCoV azelastine binding binding pocket conivaptan docking drug dynamics simulation effective FDA approved drug feature hydrophobic interaction in vitro in vivo involved main protease maintain protease repurposing residues SARS-CoV sequence homology target protein These data [DOI] 10.6026/97320630016236 PMC 바로가기 [Article Type] Research Article
The coronavirus macrodomain is required to prevent PARP-mediated inhibition of virus replication and enhancement of IFN expressionResearch Article Published on 2019-05-162022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] abundantly expressed activity addition ADP-ribose ADP-ribosylation Affect antiviral activities Antiviral effect antiviral therapy cellular Coronaviridae coronavirus Coronavirus replication Critical disease enzyme expression facilitate host cell host response human cells identify IFN immune response in vivo independent inhibited inhibitor Innate immunity interferon knockdown less macrodomain Macrophage mice Modification monomer murine mutant mutant virus Mutation PARP PARP12 PARP14 PARPs pathogenic Polymer post-translational modification Prevent Protein Regulation Replication required significantly siRNAs target protein These data Togaviridae virulence virus virus infection virus replication Virus-host interaction viruses while wild-type wild-type virus [DOI] 10.1371/journal.ppat.1007756 PMC 바로가기 [Article Type] Research Article
Neutralizing antibodies against porcine epidemic diarrhea virus block virus attachment and internalizationResearch Published on 2018-08-302022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] 2B11 antibody attachment B cell binding blocked cause Cell conformational defined epidemic diarrhea epitope expression generate host cell receptor identify Infection inhibit inhibited Isolating mAb mechanism monoclonal antibody neutralized neutralizing antibody pathogenic coronavirus PEDV Porcine epidemic diarrhea virus prokaryotic expression system qPCR receptor-binding domains Result S protein secrete specific antibodies suggested supplementary material Surface glycoprotein target protein the receptor-binding domain Vero cells Vero E6 cell viral spike virions virus virus entry virus infection was performed was used were used [DOI] 10.1186/s12985-018-1042-3 PMC 바로가기 [Article Type] Research
The Caenorhabditis elegans Protein FIC-1 Is an AMPylase That Covalently Modifies Heat-Shock 70 Family Proteins, Translation Elongation Factors and HistonesCaenorhabditis elegans 단백질 FIC-1은 Heat-Shock 70 계열 단백질, 번역 연장 인자 및 히스톤을 공유적으로 수정하는 AMPylase입니다Research Article Published on 2016-05-032022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] approach ATP bacterial pathogen biochemical Caenorhabditis Caenorhabditis elegan Caenorhabditis elegans connection consequence conserved core histone domain elegan elegans elongation elongation factors Endoplasmic reticulum Factor Factors family family members functional Heat shock heat shock protein heat-shock protein histone identify in vitro in vivo innate immune response Innate immunity modify novel nuclear ortholog P . aeruginosa pathogen phenotype post-translational modification Previous studies previous study Protein Proteins Pseudomonas aeruginosa sequence identity substrate susceptibility target protein target proteins three-dimensional structure translation unfolded protein response UPR [DOI] 10.1371/journal.pgen.1006023 PMC 바로가기 [Article Type] Research Article