Mutations in spike protein and allele variations in ACE2 impact targeted therapy strategies against SARS-CoV-2
스파이크 단백질의 돌연변이와 ACE2의 대립유전자 변이는 SARS-CoV-2에 대한 표적 치료 전략에 영향을 미칩니다
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[키워드] ACE2
ACE2 expression
ACE2 receptor
ACE2 receptors
acute respiratory syndrome
acute respiratory syndrome coronavirus
acute respiratory syndrome coronavirus 2
allele
Amino acid
analyzed
angiotensin
angiotensin converting enzyme
angiotensin converting enzyme 2
antiviral agent
Antiviral agents
binding
caused
Chinese
clinical
Clinical data
Comorbidities
Comorbidity
coronavirus
coronavirus disease
Coronavirus disease 2019
COVID-19
COVID-19 patient
COVID-19 patients
COVID-19 progression
docking
domain
drug
drug therapy
effective
English
enzyme
enzyme-linked immunosorbent assays
exhibited
genetic data
interact
Mortality
mutant
Mutation
pandemic
Patient
peptide
Point mutation
populations
Protein
Receptor binding
Receptor-ligand docking
Renin
renin-angiotensin system
Research
SARS-CoV-2
SARS-CoV-2 pandemic
Sequence analysis
severe acute respiratory syndrome Coronavirus
spike
Spike protein
Spread
Symptom
target
targeted therapy
targets
the SARS-CoV-2
the spike protein
Transmission
treat
Treatment
treatment of COVID-19
Vaccine
variant
Variation
[DOI] 10.24272/j.issn.2095-8137.2020.301 PMC 바로가기 [Article Type] Article
[DOI] 10.24272/j.issn.2095-8137.2020.301 PMC 바로가기 [Article Type] Article