Genetic drift of human coronavirus OC43 spike gene during adaptive evolutionArticle Published on 2015-06-222022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] adaptive Analysis binding binding domain characterized coronavirus CoV CoVs Critical dN/dS dominant Epidemic Evolution FIVE Genetic genetic drift Genotype HCoV-OC43 Health human coronavirus OC43 human population human populations majority mechanism N-terminal domain NTD OC43 persistence phylodynamic Phylogenetic Positive selection prevalent S gene S protein Seven spike gene Substitution sugar the S1 subunit [DOI] 10.1038/srep11451 PMC 바로가기 [Article Type] Article
Middle East respiratory syndrome coronavirus (MERS-CoV) entry inhibitors targeting spike proteinArticle Published on 2014-10-142022-11-01 Journal: Virus research [Category] Coronavirus, MERS, [키워드] Antiviral effect binding cell entry Combination coronavirus disease effective Entry inhibitor Fatality rate fusion inhibitor global public health Infection inhibitor inhibitors inhibitory laboratory-confirmed MERS MERS case MERS-CoV MERS-CoV entry MERS-CoV infection Middle East Middle East respiratory syndrome Coronavirus neutralizing antibody nonspecific Novel coronavirus outbreak peptide Prevent prophylactic strategy RBD Receptor-binding domain Replication respiratory syndrome coronavirus S protein S1 subunit S2 subunit Safe six-helix bundle Spike protein syndrome synergistic the receptor-binding domain the S1 subunit therapeutic treat Treatment virus [DOI] 10.1016/j.virusres.2014.10.007 PMC 바로가기 [Article Type] Article
Protection conferred by a recombinant Marek’s disease virus that expresses the spike protein from infectious bronchitis virus in specific pathogen-free chickenResearch Published on 2012-05-042022-10-28 Journal: Virology Journal [Category] Coronavirus, MERS, [키워드] Clinical sign develop disease effective expresse Genome IBV IBV infection Infectious Bronchitis Virus isolate Marek’s disease virus Mild Mortality predominant Prevent protection Protein Result Specific specific pathogen-free SPF Spike protein strain the S1 subunit the spike protein Vaccine virulent virus [DOI] 10.1186/1743-422X-9-85 PMC 바로가기 [Article Type] Research
SARS Vaccine DevelopmentSynopsis Published on 2005-07-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, [키워드] acute respiratory syndrome can be used Clinical use conformational coronavirus develop Developing development effective inactivated inducer Infection Neutralizing antibodies Neutralizing epitone neutralizing epitopes Prevent Protein RBD Receptor-binding domain Recombinant protein S protein Safe SARS SARS-CoV SARS-CoV vaccine sequence Spike protein the RBD the receptor-binding domain the S1 subunit Vaccine Vaccines vector [DOI] 10.3201/eid1107.050219 PMC 바로가기 [Article Type] Synopsis
Molecular analysis of S gene of spike glycoprotein of winter dysentery bovine coronavirus circulated in Korea during 2002–2003Short Communication Published on 2004-08-262022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] Amino acid Analysis analyzed avirulent Bovine coronavirus Characteristics compared conducted coronavirus strain country diarrhea French Genetic Genetic characteristics glycoprotein homologous isolate Korean molecular analysis nucleotide Phylogenetic analysis related S gene S glycoprotein sequence significantly spike glycoprotein strain Strains the S1 subunit [DOI] 10.1016/j.virusres.2004.07.003 PMC 바로가기 [Article Type] Short Communication
Molecular analysis of the S1 subunit of the spike glycoprotein of respiratory and enteric bovine coronavirus isolatesArticle Published on 2002-01-302022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] Allelic variation alteration Amino acid amino acid change amino acid substitution Analysis analyzed antigenic Bovine coronavirus Characteristics classical cleavage site Clustering compared diarrhea different Genetic group hydrophobicity isolate isolates led to nucleotide Phylogenetic analysis polymorphism predicted Probability Protein residue Respiratory and enteric BoCV S glycoprotein S1 subunit secondary structure sequence Sequencing significant changes in spike glycoprotein strain Strains the S1 subunit two subgroups variations [DOI] 10.1016/S0168-1702(02)00004-7 PMC 바로가기 [Article Type] Article