Intracerebral Hemorrhage and Thrombocytopenia After AstraZeneca COVID-19 Vaccine: Clinical and Diagnostic Challenges of Vaccine-Induced Thrombotic ThrombocytopeniaInfectious Disease Published on 2021-09-012022-10-31 Journal: Cureus [Category] COVID-19, [키워드] adverse effect antibody AstraZeneca AstraZeneca vaccine ChAdOx1 nCoV-19 challenge clinical clinical history coronavirus disease COVID-19 COVID-19 vaccine described Diagnosis disorder ELISA enzyme-linked immunosorbent first dose functional heparin HIPAA immune individual Intracerebral hemorrhage Oxford-AstraZeneca Patient PF4 platelet activation positive prothrombotic receiving SARS-CoV-2 tested thrombocytopenia thrombosis thrombotic Vaccines [DOI] 10.7759/cureus.17637 PMC 바로가기 [Article Type] Infectious Disease
Imbalance of von Willebrand factor and ADAMTS13 axis is rather a biomarker of strong inflammation and endothelial damage than a cause of thrombotic process in critically ill COVID-19 patients폰 빌레브란트 인자와 ADAMTS13 축의 불균형은 코로나19 중환자에서 혈전 과정의 원인이라기보다는 오히려 강한 염증과 내피 손상의 바이오마커Article Published on 2021-09-012022-09-11 Journal: Journal of thrombosis and haemostasis : JTH [Category] SARS, 바이오마커, [키워드] ADAMTS13 ADAMTS13 conformation Admission alveolar capillaries alveolar capillary Antigen Biological Biomarker Biomarkers Clinical features contribute coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 patient Critically ill critically ill COVID-19 patients Critically ill patient critically ill patients D-dimer deaths deficiency disintegrin driver Drivers elevated endothelial damage enrolled factor V fibrinogen hallmark hemolytic anemia hospital Imbalance Immune-mediated induce Inflammation Laboratory parameters male-to-female ratio median age microangiopathic hemolytic anemia microthrombi Microthrombosis Mortality open Patient patients Platelet Pulmonary embolism pulmonary embolisms purpura Quantitative reported Seven severe deficiency specificity thrombocytopenia thrombocytopenic purpura thrombotic thrombotic microangiopathy Thrombotic thrombocytopenic purpura type I von Willebrand factor vWF [DOI] 10.1111/jth.15445 PMC 바로가기 [Article Type] Article
An Update on COVID-19 Vaccine Induced Thrombotic Thrombocytopenia Syndrome and Some Management RecommendationsReview Published on 2021-08-182022-10-30 Journal: Molecules [Category] COVID-19, [키워드] absence Adenovirus-vectored vaccine Affect appear AstraZeneca bleeding characterized complication of COVID-19 country COVID-19 COVID-19 disease COVID-19 vaccine Disseminated intravascular coagulation events female fibrinogen level heparin induced thrombocytopenia heparin-induced thrombocytopenia individuals induced Ischemia mass vaccination occur Patient Platelet platelet factor 4 risk risk factor syndrome thrombocytopenia thrombosis thrombotic thrombotic thrombo-cytopenic purpura Treatment Vaccine vaccine induced thrombocytopenia and thrombosis Vaccines venous venous thromboembolic worsening younger patient [DOI] 10.3390/molecules26165004 PMC 바로가기 [Article Type] Review
Association Between COVID-19 Outcomes and Patient Characteristics: A Study in an Inner-City Community HospitalInternal Medicine Published on 2021-08-172022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute respiratory syndrome Admission admitted to ICU age association average black blood cell count C-reactive protein (CRP Caucasians CCI center Characteristics Charlson Comorbidity Index Clinical characteristics Community Comorbidities Complete conditions coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients CRP level D-dimer level Data collection evaluate female FEU fibrinogen Francis hematological hematological parameters hospital hospitalized patient ICU admission in-hospital mortality increased mortality Infection Latinx Lymphocyte count lymphopenia majority male mechanical ventilation Mortality no statistical difference Odds ratio Older age other variable outcome overall mortality Patient patient population patients patients hospitalized patients who survived pilot study plasma Platelet positive Primary outcome Result retrospective Saint SARS-CoV-2 SARS-COV-2 infection secondary Sepsis serum CRP severity Sex shown significant difference significantly lower statistically significant statistically significant difference Steroids study population survivor the mortality group the patient thrombocytopenia use of steroids white White blood cell [DOI] 10.7759/cureus.17255 PMC 바로가기 [Article Type] Internal Medicine
Pathogenic Mechanisms of Vaccine-Induced Immune Thrombotic Thrombocytopenia in People Receiving Anti-COVID-19 Adenoviral-Based Vaccines: A Proposal항-COVID-19 아데노바이러스 기반 백신을 접종받는 사람들에서 백신 유도 면역 혈전성 혈소판 감소증의 병원성 기전: 제안Immunology Published on 2021-08-132022-09-11 Journal: Frontiers in Immunology [Category] MERS, 유전자 메커니즘, 진단, [키워드] ACE2 receptor activate adenoviral vectors administration affected amplify antibodies binding blood stream cell activation characterized Combination complexes component endothelia erythrocytes erytrocyte extracellular DNA favor heparin IL-6 immune immune response immune responses individual Infection Inflammatory injection leucocyte life-threatening mandatory mast cell Mast cells mechanism natural antibodies occur pathophysiological mechanism PF-4 PF4 Platelet platelet activation Platelets promote Protein receiving serum IgG spike Spike protein Spread Symptom syndrome thrombocytopenia thrombotic thrombotic event Thrombotic events Thrombotic thrombocytopenia Trigger triggering Vaccine Vaccines vector VITT [DOI] 10.3389/fimmu.2021.728513 PMC 바로가기 [Article Type] Immunology
Interactions of Spike-RBD of SARS-CoV-2 and Platelet Factor 4: New Insights in the Etiopathogenesis of ThrombosisSARS-CoV-2의 Spike-RBD와 혈소판 인자 4의 상호 작용: 혈전증의 병인 발생에 대한 새로운 통찰력Communication Published on 2021-08-092022-09-12 Journal: International Journal of Molecular Sciences [Category] MERS, 진단, [키워드] ACE2 administration adverse event aggregation anti-spike antibodies antibodies antibody binding biochemical conditions contrary cross-reactivity develop diagnosed ELISA assays evaluated evidenced expression Factor Frequency heparin insight Interaction involved much higher New pathogenic Patient PF4 Platelet platelet factor 4 Platelets pro-thrombotic Protein RBD proteins recognize reported SARS-CoV-2 SARS-CoV2 severe COVID-19 similarities similarity specific antibodies specific antibody spike Spike protein Spike-RBD Structure structures syndrome the patient therapy These data thrombocytopenia thrombosis vaccination Vaccine [DOI] 10.3390/ijms22168562 PMC 바로가기 [Article Type] Communication
COVID-19 Disease, Women’s Predominant Non-Heparin Vaccine-Induced Thrombotic Thrombocytopenia and Kounis Syndrome: A Passepartout Cytokine Storm InterplayReview Published on 2021-08-052022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] accompanied acute respiratory syndrome Adverse reactions allergenic anaphylaxis approach Better cardiovascular complication Cell complications complications of COVID-19 coronary syndrome coronavirus Coronavirus disease 2019 correlation COVID-19 COVID-19 pandemic cytokine Cytokine storm database excessive immune response glycol Google hematologic heparin heparin-induced thrombocytopenia Hypoxemia hypoxic identify immunodeficiency immunological inflammatory cell Injury Kounis syndrome manifestation mechanism microthrombi Multiorgan myocardial injury neurological Pandemics pathophysiological mechanisms pathophysiology patients with COVID-19 post vaccination post-COVID-19 vaccination Prevalence pro-inflammatory cytokine release renal rupture SARS-CoV-2 similarities storm syndrome thrombocytopenia thrombosis thrombotic event Treatment underlie Vaccine variant venous viral infection virus was performed [DOI] 10.3390/biomedicines9080959 PMC 바로가기 [Article Type] Review
Malignant cerebral infarction after ChAdOx1 nCov-19 vaccination: a catastrophic variant of vaccine-induced immune thrombotic thrombocytopeniaChAdOx1 nCov-19 백신 접종 후 악성 뇌경색: 백신 유발 면역 혈전성 혈소판 감소증의 치명적인 변종Case Reports Published on 2021-08-022022-09-10 Journal: Nature Communications [Category] MERS, SARS, 변종, 진단, [키워드] abnormality adverse effect adverse effects antibody Antimicrobial responses Arterial thrombosis catastrophic Cerebral artery ChAdOx1 ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 vaccine Coagulation system complexes contribute COVID-19 pandemic COVID-19 vaccination decompressive craniectomy described DNA vaccines effective epidemiological epidemiological links first dose geographical areas heparin immune Infarct Infarction malignant manifested middle cerebral artery observation past Patient Platelet portal Portal vein portal vein thrombosis reported stroke syndrome the patient thrombocytopenia thrombosis thrombotic Thrombotic thrombocytopenia vaccination Vaccine variant Venous thrombosis with COVID-19 [DOI] 10.1038/s41467-021-25010-x PMC 바로가기 [Article Type] Case Reports
COVID-19 vaccine-associated immune thrombosis and thrombocytopenia (VITT): Diagnostic and therapeutic recommendations for a new syndromeCOVID-19 백신 관련 면역 혈전증 및 혈소판 감소증(VITT): 새로운 증후군에 대한 진단 및 치료 권장 사항Review Published on 2021-08-012022-09-11 Journal: European journal of haematology [Category] SARS, 바이오마커, [키워드] AstraZeneca AstraZeneca vaccine carried Cerebral venous thrombosis clinically Continuous COVID-19 COVID-19 vaccination COVID-19 vaccine help heparin immune incidence information International knowledge management National occurred Pathogenesis pathogenic mechanism Patient Patient management recommendation reported syndrome therapeutic thrombocytopenia thrombosis thrombotic vaccination venous with COVID-19 [DOI] 10.1111/ejh.13665 PMC 바로가기 [Article Type] Review
Secondary Immune Thrombocytopenia (ITP) Associated with ChAdOx1 Covid-19 Vaccination – A Case ReportCase Report Published on 2021-07-302022-10-29 Journal: TH Open: Companion Journal to Thrombosis and Haemostasis [Category] COVID-19, [키워드] aquired association AstraZeneca caused ChAdOx1 ChAdOx1 nCoV-19 coagulation disorder Complication complications country COVID vaccination COVID-19 infections Efficacy Europe Hemorrhagic immune Immune thrombocytopenia Infectious diseases ITP ITP associated with AstraZeneca Covid vaccination ITP associated with Covid vaccination less life-threatening management media mRNA novel performed platelet pathology / inherited prothrombotic report reported secondary secondary ITP shown Side effect symptomatic thrombocytopenia thrombotic vaccination Vaccinations Vaccine [DOI] 10.1055/s-0041-1731774 PMC 바로가기 [Article Type] Case Report