Comprehensive fitness landscape of SARS-CoV-2 M pro reveals insights into viral resistance mechanisms
SARS-CoV-2 M pro의 종합적인 피트니스 환경은 바이러스 저항 메커니즘에 대한 통찰력을 보여줍니다
Article
[키워드] active site
acute respiratory syndrome
acute respiratory syndrome coronavirus
acute respiratory syndrome coronavirus-2
addition
Amino acid
amino acid changes
amino acids
analyzed
Anti-viral drugs
can be used
cleave
Complete
Comprehensive
conserved
contribute
Coronavirus-2
correlated
Critical
deep mutational scanning
deep sequencing
defined
drug
drug design
drug resistance
Effect
effective
elicit
evade
Evolution
Evolutionary biology
expression
functional
human population
Infectious disease
inhibitor
inhibitors
life cycle
M pro
main protease
mechanism
Microbiology
MPro
Mutation
network
new strain
performed
physically
protease
Protein
reduced
reveal
S. cerevisiae
SARS-CoV-2
SARS-CoV-2 main protease
selection pressure
Severe acute respiratory syndrome
severe acute respiratory syndrome Coronavirus
Toxicity
Vaccines
variant
viral life cycle
Viral resistance
virulent
yeast
[DOI] 10.7554/eLife.77433 PMC 바로가기 [Article Type] Article
[DOI] 10.7554/eLife.77433 PMC 바로가기 [Article Type] Article