The derived allele of a novel intergenic variant at chromosome 11 associates with lower body mass index and a favorable metabolic phenotype in Greenlanders11번 염색체에 있는 새로운 유전자간 변이의 파생된 대립유전자는 그린랜더의 낮은 체질량 지수 및 유리한 대사 표현형과 관련이 있습니다Research Article Published on 2020-01-242022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adipose Adipose tissue affected affecting Alaska allele alteration Analysis Arctic association Author Beta biological processe biological processes BMI body mass body mass index body-mass body-mass index cholesterol chromosome chromosome 11 Cohort cohorts contribute derived allele expand Fat mass Frequency G allele G-allele Genetic genetic architecture genetic loci Genetic predisposition Genetic variant genetic variants genome-wide significant HDL-cholesterol identify independent insulin insulin resistance knowledge lean mass measure mechanism Meta-analysis Native obesity performed phenotype physical activity populations remained replicate Replication required risk significantly Stage stage 2 study population target targets the stage tissue traits Treatment Triglyceride variant visceral Waist circumference weight were assessed [DOI] 10.1371/journal.pgen.1008544 PMC 바로가기 [Article Type] Research Article
Roles of Candida albicans Mig1 and Mig2 in glucose repression, pathogenicity traits, and SNF1 essentiality포도당 억제, 병원성 특성 및 SNF1 본질에서 Candida albicans Mig1 및 Mig2의 역할Research Article Published on 2020-01-212022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acquisition addition biofilm Candida Candida albican Candida albicans carbon carbon metabolism carbon source Cell cell wall colonize connection Control distinctive features endothelial cells eukaryotic explain expression feature function fungal Gene Expression Gene regulation Genes Genetic Glucose help Host hyphae identify include indication Infection inhibitors Macrophage mediators metabolic metabolism opportunistic pathogen organism ortholog orthologs pathogen pathogenicity pathway Protein protein kinase regulated Regulation repressed required role Saccharomyces cerevisiae second tissues Tolerance traits transcription factor transcription factors unique viability yeast [DOI] 10.1371/journal.pgen.1008582 PMC 바로가기 [Article Type] Research Article
Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations정밀 의학(TOPMed)을 위한 100,000개 이상의 NHLBI Trans-Omics 컨소시엄 전체 게놈 서열의 사용은 아프리카 및 히스패닉/라틴계 혼합 인구 집단에서 전가 품질 및 희귀 변이 연관성 검출 개선Research Article Published on 2019-12-232022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 1000 Genomes Project addition African allele Analysis Anemia approach association average blood cell complex complex diseases conducted demonstrated European Frequency genetic architecture Genetic studies genetic study genome coverage genome-wide association genome-wide genotyping genome-wide significant Genotype genotype data genotype imputation genotypes Haplotype Reference Consortium HBB HBB gene HCT hematocrit hematological hemoglobin highlight homozygous impair IMPROVE imputation increase in independent individual information Linkage disequilibrium low frequency MAF mapping Medicine minor allele frequency MOST NHLBI phase Population populations power Quantitative rare variant Rare variants reference panel replicated rescued sequence Sequencing sequencing data subsequent traits utility variant variants WBC White blood cell white blood cell count whole genome whole genome sequence Whole genome sequencing [DOI] 10.1371/journal.pgen.1008500 PMC 바로가기 [Article Type] Research Article
The genetic architecture of helminth-specific immune responses in a wild population of Soay sheep ( Ovis aries )Soay 양의 야생 개체군에서 기생충 특이적 면역 반응의 유전적 구조( Ovis aries )Research Article Published on 2019-11-072022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Adults Affect antibody antibody level antibody levels blood plasma chromosome CIITA class CLEC16A collected complex condition conditions Containing contribute driver Drivers ecological Effect Evidence evidence of Genetic genetic architecture genetic control Genetic variation genomic region heritable variation histocompatibility Host hosts humans identify IgA IgA level IgA levels IgE IgG IgG antibodies IgG antibody IgG level IgG levels IGH immune Immune profile immune response immune responses Immunity Immunoglobulin immunological Infection influence investigated knowledge Laboratory lectin loci maintain Major major histocompatibility complex MHC natural populations natural selection nematodes offer Organisms Ovis parasite parasites Population prevalent provide response sheep significantly the major histocompatibility traits understanding Variation while [DOI] 10.1371/journal.pgen.1008461 PMC 바로가기 [Article Type] Research Article
Causal relationships between obesity and the leading causes of death in women and men비만과 여성과 남성의 주요 사망 원인 사이의 인과 관계Research Article Published on 2019-10-242022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adjusted Affect Analysis association blood pressure BMI body mass body mass index cardiometabolic disease cardiometabolic diseases causal relationship causal relationships cause Chronic kidney disease chronic liver disease chronic obstructive chronic obstructive pulmonary disease chronic renal failure Cochran’s Q-test Coronary artery Coronary artery disease death diabete diabetes Diabetes Mellitus disease disease risk downstream Effect etiological Fatty liver fatty liver disease genetic data genetic risk score genetic variants glycemic GRS heart disease higher risk implicated implication increase increased risk indicate instrumental variable instrumental variables investigated involved Kidney disease lung cancer majority mediators men men and women mendelian randomization Mortality Non-alcoholic fatty liver disease non-communicable diseases obesity obstructive pulmonary disease preventative measure public health pulmonary disease renal renal failure risk smoking Still stroke traits type 2 diabete type 2 diabetes UK biobank waist waist-hip ratio Waist-hip-ratio WHR women [DOI] 10.1371/journal.pgen.1008405 PMC 바로가기 [Article Type] Research Article
Epistatic control of intrinsic resistance by virulence genes in Listeria리스테리아의 병독성 유전자에 의한 내인성 내성의 상위성 조절Research Article Published on 2018-09-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activated Activation addition antibiotic antimicrobial resistance antimicrobial susceptibility Bacteria Bacterial bacterial cell complex conditions core genome determinant dissect drug drug-resistant Effect enzyme epistasis Evidence Evolution evolutionary dynamics fosfomycin functional Genes genomic gram gram-positive bacterium Host in vitro induce Infection Infectious disease Interaction intrinsic intrinsically isolate L . monocytogene Listeria Listeria monocytogene Listeria monocytogenes listeriosis loci locus mechanism microbe molecular molecular basis organism pathogen pathogenic Pathogens phenomenon phenotype phenotypic effect Population dynamics prfA PROTECT provide rationale reported resistance gene resistance genes Strains suppressed susceptibility susceptible traits treat Treatment understanding virulence virulence gene virulence genes virulent working [DOI] 10.1371/journal.pgen.1007525 PMC 바로가기 [Article Type] Research Article
Evolution via recombination: Cell-to-cell contact facilitates larger recombination events in Streptococcus pneumoniae재조합을 통한 진화: 세포 간 접촉은 Streptococcus pneumoniae에서 더 큰 재조합 사건을 촉진합니다Research Article Published on 2018-06-132022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 폐렴구균 감염증, [키워드] adaptation added arising Bacteria Bacterial Cell cells Cluster co-culture competent conditions Contact Culture cultures DNA Donor events Evolution facilitate gene transfer genetic transformation Genome genomes Homologous recombination horizontal gene Horizontal gene transfer Human involved Laboratory less mapped Millipore mixed cultures nasopharynx occur organism parent pathogen pneumococcal pneumococci pneumoniae purified recombinant recombinants Recombination recombination event Sequencing Sex sexual reproduction significantly significantly increased singular SNP SNPs strain Strains Streptococcus pneumoniae thought traits transfer transferred undergo WGS while whole genome Whole genome sequencing [DOI] 10.1371/journal.pgen.1007410 PMC 바로가기 [Article Type] Research Article
Functional diversification accompanies gene family expansion of MED2 homologs in Candida albicans기능적 다양화는 칸디다 알비칸스에서 MED2 상동체의 유전자 패밀리 확장을 수반합니다Research Article Published on 2018-04-092022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 3’ end accompany addressed affected aggregation biological function Biological functions buffer Candida Candida albican Candida albicans Cell Combination commensal complex component conserved contribute contributed correlated did not produce difficulty domain duplication Effect entire gene example expansion expression facilitate family members function functional functions Gene duplication gene families gene family generate Genes genetic diversity greater growth homolog identify INDEL individual gene individual genes induced Infection influence involved killing Macrophage mapped mechanism mediator Mutation natural selection neofunctionalization occurred opportunistic pathogen organism overlap pathogen pathogenic phenotype Phenotypes phenotypic phenotypic effect polymorphic site Positive selection promoter provide question regulate regulated Regulation Regulatory repeated selective pressure sequence sequence similarity Specific strain Strains subfunctionalization subunit sucrose traits transcriptional transcriptional regulator unique Variability variant virulence were assessed yeast [DOI] 10.1371/journal.pgen.1007326 PMC 바로가기 [Article Type] Research Article
Analysis of nuclear and organellar genomes of Plasmodium knowlesi in humans reveals ancient population structure and recent recombination among host-specific subpopulations인간에서 Plasmodium Knowlesi의 핵 및 소기관 게놈 분석은 고대 개체군 구조와 숙주 특이적 하위 개체군 간의 최근 재조합을 보여줍니다Research Article Published on 2017-09-182022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 말라리아, [키워드] Analysis Appropriate Asia assist chromosome complex comprehensive analysis Contact contact with deforestation described Disruption ecological Evidence evidence of Evolution expected expressed genes encoding Genetic genetics Genome genome sequence genomic genotypes growth Host hosts Human human infection human population humans infecting Infection infections Interaction isolate Isolation likelihood Lineage lineages macaque macaques malaria malaria control Malaysia molecular nuclear organelle parasite parasites Plasmodium Population population growth Prevalence Protein Rapid Recombination reference genome Region resulting reveal sampling selected stages subpopulation subpopulations Surveillance switching traits Transmission [DOI] 10.1371/journal.pgen.1007008 PMC 바로가기 [Article Type] Research Article
Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations단일 특성 및 다중 특성 게놈 전체 연관 분석을 통해 아프리카 계통 인구의 혈압에 대한 새로운 유전자좌 식별Research Article Published on 2017-05-122022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Affect African African American African Americans allele alleles analyses Analysis analyzed angiotensin biologic blood pressure CDH17 cells complications conducted contributing to Diastolic blood pressure disability disease driven by enrichment Evidence experimental models expressed expression Factor FRMD3 functional annotation Genes Genetic studies genome-wide association Genome-wide association study genome-wide significance genomic region Health health problem hypertension identify immune independent individual kidney kidney tissue LLPH loci locus mice Mortality mRNA expression nine performed Population populations provide reached reported Research risk Support susceptibility susceptibility loci systolic TARID TCF21 TMBIM4 traits variant Vascular while [DOI] 10.1371/journal.pgen.1006728 PMC 바로가기 [Article Type] Research Article