Transcriptome-module phenotype association study implicates extracellular vesicles biogenesis in Plasmodium falciparum artemisinin resistancearticle Published on 2022-08-312024-09-01 Journal: Frontiers in Cellular and Infection Microbiology [Category] 말라리아, [키워드] Artemisinin resistance association Extracellular vesicles modules Plasmodium falciparum transcriptomics [Article Type] article
Lung epithelial and myeloid innate immunity in influenza-associated or COVID-19-associated pulmonary aspergillosis: an observational studyResearch article Published on 2022-08-242022-10-05 Journal: The Lancet. Respiratory Medicine [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, 진단, [키워드] admitted to ICU Affect affecting Analysis Antwerp Aspergillus autophagy Belgium Bronchoalveolar lavage fluid bronchoalveolar lavage sample bronchoalveolar lavage samples calculate Cell chemokines collected Concentration conidia COVID-19 Critically ill patient Cytokines development diagnose differentially expressed disrupting downregulated downregulation elevated Eligible patients encoding protein enrichment analysis epithelial European expression expression data finding foundation fraction France function funding Gene expression analysis growth factor Horizon hospital hyphae ICU IFNγ IL-1β Immunity in vivo increased mortality Influenza Influenza virus Innate immunity intensive care invasive invasive ventilation investigated kill killing lung epithelial Max Planck Society network neutrophil Neutrophils Non-invasive pathophysiology pathway Pathway analysis Pathways Patient patients patients with COVID-19 patients with influenza performed phagocytosis Protein recruited Regional retrieved SARS-COV-2 infection SARS-CoV-2 RNA several gene significantly significantly lower spores TNF-α tracheobronchial transcriptomics Treatment Type I IFN type II IFN university University Hospitals Leuven were used [DOI] 10.1016/S2213-2600(22)00259-4 [Article Type] Research article
Primary cilia and SHH signaling impairments in human and mouse models of Parkinson’s disease Research Published on 2022-08-162022-10-05 Journal: Nature Communications [Category] 유전자 메커니즘, 진단, 치료기술, [키워드] accompanied alteration arise Cell cellular ciliary detect dysfunction environmental factors Gene Expression Genetic hedgehog impairment inhibition mitochondrial dysfunction morphology mouse model neurodegenerative disorder neurons observé overactive Parkinson’s disease pathological mechanism pathway patients phenotype precursor required SHH Signal transduction Signaling single-cell therapy transcriptomics [DOI] 10.1038/s41467-022-32229-9 [Article Type] Research
Antibody therapy reverses biological signatures of COVID-19 progression항체 요법은 COVID-19 진행의 생물학적 특징을 역전시킵니다.Randomized Controlled Trial Published on 2022-08-162022-09-11 Journal: Cell Reports Medicine [Category] SARS, 바이오마커, 임상, 진단, 치료기술, [키워드] 1:1 Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antibody therapy antibody treatment Biomarkers clinical decision clinical trial coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 progression Decision making decrease Disease progression disease severity e parameters effective facilitate greater Hospitalized identify Infection Laboratory parameters lymphocyte marker monoclonal antibody Nasopharyngeal samples neutrophil Neutrophil-to-lymphocyte ratio NLR normalization occur parameter participant Placebo prediction Predictive profiles progression provide Randomized respiratory risk risk for disease SARS-CoV-2 serologic test severe acute respiratory syndrome Coronavirus severe coronavirus disease severe disease Sotrovimab study participant Study participants Transcriptome transcriptomic profile transcriptomics Treatment understanding Viral Viral RNA [DOI] 10.1016/j.xcrm.2022.100721 PMC 바로가기 [Article Type] Randomized Controlled Trial
An improved Fuzzy based GWO algorithm for predicting the potential host receptor of COVID-19 infectionResearch article Published on 2022-08-012022-10-05 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 protein acute respiratory syndrome ADAM17 Affect affected Algorithm analyzed ASGR1 Asialoglycoprotein Basigin Bone marrow Brain caused CD147 Cell CLEC4M Cluster Clustering Coronavirus-2 COVID-19 COVID-19 infection cytoplasm Differential evolution algorithm disease disintegrin domain drug effective Effectiveness eliminating entry of SARS-CoV-2 enzyme Evolution population dynamics exploratory expresse expression profile EXT1 EXT2 EXT3 Factor fusing Fuzzy clustering G protein-coupled receptor genetic diversity GLCE Glucuronic acid GPR78 Grey Grey wolf optimizer help Host host cell host cell membrane host receptor humans hybridizing I, II identify identifying IHC immunohistochemistry individual Infection inhibiting Interaction intestine kidney KREMEN1 Kringle liver lung mechanism membrane protein Membrane proteins Mutation NDST2 neuropilin NRP1 operator pathogenesis of COVID-19 pathogenesis of SARS-CoV-2 pathogenicity protease Protein PVR receptor replication of SARS-CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 virus serine protease Seurat shown Single cell RNA sequencing data single-cell Spike protein spleen Spread therapeutic target TMPRSS2 toolkit transcriptionally transcriptomics transmembrane protein Transmission virus XYLT1 XYLT2 [DOI] 10.1016/j.compbiomed.2022.106050 [Article Type] Research article
Exposure of Anopheles gambiae larvae to a sub-lethal dose of an agrochemical mixture induces tolerance to adulticides used in vector control managementArticle Published on 2022-07-312024-09-10 Journal: Aquat Toxicol [Category] 말라리아, [키워드] Agrochemical pesticides An. gambiae Clothianidin Cuticle resistance Fludora® Fusion Metabolic resistance transcriptomics PMC 바로가기
Effect of the Interaction between Viral PB2 and Host SphK1 on H9N2 AIV Replication in MammalsArticle Published on 2022-07-212023-06-22 Journal: Viruses [Category] 조류인플루엔자, [키워드] DK1-like lineage PB2 gene H9N2 avian influenza virus SphK1 transcriptomics [DOI] 10.3390/v14071585 PMC 바로가기
Are mRNA based transcriptomic signatures ready for diagnosing tuberculosis in the clinic? – A review of evidence and the technological landscapeReview article Published on 2022-07-152022-10-05 Journal: EBioMedicine [Category] 비임상, [키워드] accelerate addressed advance conducted cut-off defined develop development diagnosing diagnostic diagnostic tests disease evaluate Evidence Fold change funding group groups had no individual Interpretation limit limitations maintain management manuscript MONITOR mRNA mRNA signature New partnership Point-of-care TB diagnostics Population positive predict prognostic progression Prospective Study Sample size shown specificity STOP supported transcriptomic transcriptomics Treatment Tuberculosis working [DOI] 10.1016/j.ebiom.2022.104174 [Article Type] Review article
A single-cell liver atlas of Plasmodium vivax infectionArticle Published on 2022-07-132024-08-28 Journal: Cell Host & Microbe [Category] 말라리아, [키워드] dormancy host-parasite interactions Hypnozoites liver stage MPCC Plasmodium vivax Seq-Well single-cell transcriptomics Transmission
SARS-CoV-2 infection of human-induced pluripotent stem cells-derived lung lineage cells evokes inflammatory and chemosensory responses by targeting mitochondrial pathways인간 유도 만능 줄기 세포 유래 폐 계통 세포의 SARS-CoV-2 감염은 미토콘드리아 경로를 표적으로 하여 염증 및 화학 감각 반응을 유발합니다Article Published on 2022-07-012022-09-12 Journal: Journal of cellular physiology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] activated acute respiratory syndrome addition Affect airway alveolar alveolar cells Antiviral Apoptosis caused Cell cells chemosensory chemosensory response complexes Consequences coronavirus COVID-19 COVID-19 disease COVID-19 patients Defense developmental distal dysregulation epithelial HMOX1 IL-13 IL-6 immune responses in viral in vitro Increased induced pluripotent stem cells INF-γ infected cell Inflammatory Inflammatory response Lineage lung lung epithelial Lung epithelial cells Lung injury lung tissue maturation mechanism metabolic processe mitochondrial mitochondrial damage. pathway precursor Proinflammatory cytokine proximal replicated response resulting robust ROS ROS production SARS-CoV-2 SARS-COV-2 infection spatiotemporal therapeutic drug TNF-α transcriptomics Transport upregulated upregulation [DOI] 10.1002/jcp.30755 PMC 바로가기 [Article Type] Article