Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
생명을 위협하는 COVID-19 환자에서 I형 IFN 면역의 선천적 오류
Research Article
[키워드] a minor
acute respiratory syndrome
acute respiratory syndrome coronavirus
acute respiratory syndrome coronavirus 2
administration
Affect
affecting
age
amplification
amplification pathway
Asymptomatic
autoantibodies
autoantibody
autoantibody system
autosomal-dominant
autosomal-recessive
Beck
biochemically
BOLD
candidate gene approach
caused
cellular
clinical
Clinical course
Clinical outcome
clinical variability
complete penetrance
complex
component
components
core gene
core genes
coronavirus
coronavirus disease
Coronavirus disease 2019
Course
COVID
COVID Human Genetic Effort
COVID-19
COVID-19 patient
COVID-19 pneumonia
Critical
Critical disease
cytokine
Cytokines
damage
dampen
deficiencies
deficiency
defined
Deleterious
dendritic cell
dendritic cells
determine
Diseases
double-stranded RNA
eight
enrichment
epidemiological studies
Exome
fibroblast
fibroblasts
Genes
genes encoding
genetic defect
genetic defects
genetics
Genome
genomics study
had milder phenotype
healthy individuals
highest
Hospitalized
Human
human fibroblasts with mutations
Hypothesis
identify
IFN
IFN response
IFN-α2
IFNAR1
IFNAR1 deficiency
IFNAR2
IFNs
IKBKG
immune system
Immunity
immunological
in healthy individuals
in some
in vitro
Inborn error
Inborn errors
incomplete penetrance
individual
induction pathway
Infection
infection with SARS-CoV-2
Infectious diseases
Influenza
influenza pneumonia
Influenza virus
inheritance
interferon
interferon regulatory factor
interferon regulatory factor 7
interferons
interferons (IFNs)
involved
IRF3
IRF7
IRF9
lack
life-threatening
likelihood
loci
LOF
loss-of-function
male
mechanism
Medical conditions
minor
minor allele frequency
molecular
molecule
molecules
monogenic inborn error
monogenic inborn errors
mutated
Mutation
NEMO
NEMO/IKBKG
Neutralizing
nonsynonymous variant
other variants
outcome
pathogen
pathogen-induced inflammation
pathway
Patient
patients
Perspective
plasmacytoid dendritic cells
pLOF
Pneumonia
predicted
Prevent
produced
rare variant
Rare variants
Regulation
respiratory
reveal
risk
risk factor
SARS-CoV-2
SARS-COV-2 infection
SARS-CoV-2 infection in vitro
Science
selected
sequenced
severe acute respiratory syndrome Coronavirus
severe acute respiratory syndrome coronavirus 2
severe coronavirus disease
severe COVID-19
Severe COVID-19 pneumonia
severe disease
Severe infection
silent infection
Stat1
STAT2
subject
susceptible
TBK1
tested
Therapeutic benefit
this system
TICAM1
TICAM1/TRIF
tissue
TLR3
Toll-like receptor
Toll-like receptor 3
TRAF3
TRIF
Type
type I
Type I IFN
type I IFNs
type I interferon
UNC93B1
underlie
variant
variants
Viral
Viral illness
viral illnesses
[DOI] 10.1126/science.abd4570 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1126/science.abd4570 PMC 바로가기 [Article Type] Research Article