upstream – Page 11 – Communicable Diseases Research

Ultra-High-Throughput Clinical Proteomics Reveals Classifiers of COVID-19 Infection

Article

Published on 2020-07-222022-10-04
Journal: Cell Systems [Category] SARS, 바이오마커, 유전자 메커니즘,

Cryo-EM analysis of the post-fusion structure of the SARS-CoV spike glycoprotein

Article

Published on 2020-07-172022-10-04
Journal: Nature Communications [Category] SARS, 변종, 치료제,

Protein Coding and Long Noncoding RNA (lncRNA) Transcriptional Landscape in SARS-CoV-2 Infected Bronchial Epithelial Cells Highlight a Role for Interferon and Inflammatory Response

Article

Published on 2020-07-072022-10-31
Journal: Genes [Category] COVID-19, SARS,

[키워드] activated Activation acute inflammatory response acute respiratory syndrome Analysis Antiviral antiviral response bioinformatics Biomarkers bronchial bronchial epithelial bronchial epithelial cell category caused Cell cell death cells Community coronavirus Course COVID-19 differentially expressed disease expressed gene expression functional functional annotation gene expressions gene target hallmark highlight host cells host response Ifi44 IFI44L IFIT1 IFIT2 IFIT3 IFITM1 IFN IFN response IgG immune response Immunoglobulin in vitro induction Infection innate response interferon Interferon lambda investigated involved IPA IRF9 landscape lncRNA lncRNAs Long long noncoding RNA lung tissue MAPK MX1 Necrosis network analysis NHBE OAS2 OAS3 Ontology pathogenesis of COVID-19 pathogenic Pathway analysis Patient Replication Research response RNA role SARS-CoV-2 SARS-COV-2 infection spread of COVID-19 suppressed tissue TNF Transcriptome upregulated upstream viral infection Viral protein with COVID-19
[DOI] 10.3390/genes11070760 PMC 바로가기 [Article Type] Article

Kawasaki-like diseases and thrombotic coagulopathy in COVID-19: delayed over-activation of the STING pathway?

Review

Published on 2020-07-052022-10-31
Journal: Emerging Microbes & Infections [Category] COVID-19, MERS,

[키워드] ACE2 activate Activation aneurysms Aspirin binding bleeding cell membrane children Coagulopathy Combination contribute COVID-19 COVID-19 patient cytosolic disease disorder DNA down-regulated downstream drug Herpes virus Hypothesis IL-6R immunoglobulins Inflammasome inhibit inhibited inhibitor innate cell intravenous IVIG JAK/STAT pathways Kawasaki disease lung tissue males mice monocyte-macrophages NLRP3 occur over-expressed pathway procoagulant activity promote prothrombotic pyroptosis reduce reported risk SARS-CoV2 severe COVID-19 patient severe COVID-19 patients Signaling STING thrombosis thrombotic tissue Tissue Factor Treatment triggering upstream Vasculitis viruses
[DOI] 10.1080/22221751.2020.1785336 PMC 바로가기 [Article Type] Review

How to Fight an Infodemic: The Four Pillars of Infodemic Management

Editorial

Published on 2020-06-292022-10-30
Journal: Journal of Medical Internet Research [Category] Coronavirus, SARS,

Tripartite Combination of Candidate Pandemic Mitigation Agents: Vitamin D, Quercetin, and Estradiol Manifest Properties of Medicinal Agents for Targeted Mitigation of the COVID-19 Pandemic Defined by Genomics-Guided Tracing of SARS-CoV-2 Targets in Human Cells

대유행 완화제 후보의 삼자 조합: 인간 세포에서 SARS-CoV-2 표적의 게놈 유도 추적으로 정의된 COVID-19 대유행의 표적 완화를 위한 약제의 비타민 D, 케르세틴 및 에스트라디올 매니페스트 특성

Article

Published on 2020-05-212022-09-10
Journal: Biomedicines [Category] 비임상,

[키워드] 2019 coronavirus disease ACE2 activity Affect agent Alter analyses Analysis breath build candidate cell types cellular clinical trial clinical trials Combination condition contribute coronavirus coronavirus disease Coronavirus infection COVID-19 COVID-19 pandemic deficiency disease drug drugs drugs and medicinal substance repurposing Effect elements enrichment eriodictyol estradiol experiment expression expression profiling facilitate Follow-up function functions furin FURIN expression FURIN gene GATA5 gene expression profile Gene expression profiles gene expression signature Gene Set Enrichment Analyses gene silencing Genomics GSEA HIF1a high mortality HMGA2 HNF4A Human human body human cell human cells human gene human genes hypothetical identify Immediate Immune cell immune cells Immunosuppression Impact infect Infection Inference inhibitor inhibitors of SARS-CoV-2 INSIG1 interfere Intervention intrinsically Luteolin majority male Mitigation mitigation approaches molecular Mortality observation observational study observations Older overexpression pandemic Panel Patient persistence present property Protein Protein target protein targets Proteins quercetin Randomized randomized clinical trial Regulatory reported repressor required RUNX1 SARS-CoV-2 SARS-CoV-2 coronavirus SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 viral selective severity SFTPC smoking Spread SUMMIT drug-docking screen target targets Testosterone the SARS-CoV-2 tissues tracing Transgenic mouse Treatment upstream utility Viral Viral protein Viral proteins virus Vitamin D vitamin D deficiency website
[DOI] 10.3390/biomedicines8050129 PMC 바로가기 [Article Type] Article

Identification of a novel base J binding protein complex involved in RNA polymerase II transcription termination in trypanosomes

트리파노솜에서 RNA 중합효소 II 전사 종결에 관여하는 새로운 염기 J 결합 단백질 복합체의 확인

Research Article

Published on 2020-02-212022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] Ablation addition African sleeping sickness Analysis base binding binding domain cause co-IP complex dephosphorylation derepression described DNA downstream genes Epigenetic eukaryotes expand expressed expression Factors gene cluster gene clusters Gene Expression Genome homolog Host Human humans identification identify immune evasion Interaction involved lead leads Leishmania mammalian mass spectrometry mechanism Modification mutant mutants organism Organisms organized phosphatase promoter Protein protein complex Protozoa Reciprocal recruitment regulate regulated Regulatory residue RNA RNA Polymerase II RNA-Seq RNAi RT-PCR shown significantly silent sleeping sickness specific proteins sucrose surface Surface glycoprotein termination thymine Transcription transcription start sites Trypanosoma Trypanosoma brucei Trypanosome upstream variant Variant Surface Glycoprotein Wdr82 yeast
[DOI] 10.1371/journal.pgen.1008390 PMC 바로가기 [Article Type] Research Article

The S2 Subunit of QX-type Infectious Bronchitis Coronavirus Spike Protein Is an Essential Determinant of Neurotropism

Article

Published on 2019-10-222022-10-28
Journal: Viruses [Category] Coronavirus, MERS,

Biofilm-associated toxin and extracellular protease cooperatively suppress competitors in Bacillus subtilis biofilms

생물막 관련 독소 및 세포외 프로테아제는 Bacillus subtilis 생물막에서 경쟁자를 협력적으로 억제합니다

Research Article

Published on 2019-10-172022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] aggregate Alter antibiotic Antibiotics Antimicrobials assistance B . subtilis Bacillus subtilis Bacteria Bacterial bacterial composition biofilm Cell cells combating contribute Defense DEGs demonstrated diffusion Diseases effective eliminated excluded expression Extracellular food contamination growth impair Infectious diseases inhibit leads medium multicellular mutant mutations Neutral observation overexpression penetrate peptide Polymer polymers Prevent problem problems protease PROTECT Protein Regulatory required resistance gene resistance genes secreted solid medium Space suppress Taking Tolerance Treatment type strain upstream wild-type strain
[DOI] 10.1371/journal.pgen.1008232 PMC 바로가기 [Article Type] Research Article

A new identified suppressor of Cdc7p/SepH kinase, PomA, regulates fungal asexual reproduction via affecting phosphorylation of MAPK-HogA

Cdc7p/SepH 키나아제의 새로 확인된 억제제인 PomA는 MAPK-HogA의 인산화에 영향을 주어 진균 무성 생식을 조절합니다

Research Article

Published on 2019-06-132022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,