SARS-CoV-2 and Other Respiratory Viruses: What Does Oxidative Stress Have to Do with It?Review Article Published on 2020-12-212022-10-29 Journal: Oxidative Medicine and Cellular Longevity [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome Affect antioxidant antiviral response antiviral therapy cellular characterized Compound coronavirus COVID-19 pandemic Inflammatory information knowledge mechanism Other oxidative pathway oxidative stress pathophysiology reactive reactive oxygen specy respiratory respiratory viral infections responses SARS-CoV-2 therapeutic targets viral infection viral infections viral pathogenesis [DOI] 10.1155/2020/8844280 PMC 바로가기 [Article Type] Review Article
SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivoSARS-CoV-2 D614G 변이체는 생체 외에서 효율적인 복제 및 생체 내 전달을 나타냅니다.Report Published on 2020-12-182022-09-10 Journal: Science (New York, N.y.) [Category] MERS, SARS, 변종, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alter angiotensin animal models Antisera appear both virus both viruses change Changing Characteristics China coronavirus D614G D614G substitution D614G variant dominant Effect Efficacy ENhance enzyme epithelial cell epithelial cells Ex vivo exhibit experiment faster glycine greater greater transmissibility hamster hamsters Human human Angiotensin-converting enzyme human cell human cells in vitro in vivo indicate infecting Infection maintain morphology Mutation neutralization Neutralizing new virus pandemic spread Pathogenesis pathogenicity Population prevalent primary human airway Primary human airway epithelial cells primary human cell primary human cells pulmonary disease replaced REPLACED BY replicate Replication respiratory respiratory tissue respiratory tissues SARS-CoV-2 SARS-CoV-2 D614G SARS-CoV-2 variant Science severe acute respiratory syndrome Coronavirus significantly Spike protein strain Strains susceptible the times These data transgenic mice Transmissibility Transmission vaccine candidate vaccine candidates variant variant of SARS-CoV-2 Viral viral pathogenesis viral spike protein viral titer virulence virus viruses wild-type virus [DOI] 10.1126/science.abe8499 PMC 바로가기 [Article Type] Report
Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic miceK18 인간 안지오텐신 전환 효소 2 형질전환 마우스에서 SARS-CoV-2 감염의 치사율Article Published on 2020-11-302022-09-10 Journal: Nature Communications [Category] 치료기술, [키워드] airway epithelium angiotensin angiotensin converting enzyme animal model animal models Antiviral benefit both lungs Brain characterization chemokine COVID-19 disease cytokeratin 18 promoter cytokine Cytokine storm enzyme expressing hACE2 human angiotensin converting enzyme 2 human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 induce Infection K18 K18-hACE2 lethality lung mice Pathogenesis peaked produced Prophylactic SARS-CoV-2 SARS-COV-2 infection severe COVID-19 disease spleen susceptible therapeutic Therapeutics transgenic mice Vaccine Viral viral infection viral pathogenesis virus [DOI] 10.1038/s41467-020-19891-7 PMC 바로가기 [Article Type] Article
In silico studies evidenced the role of structurally diverse plant secondary metabolites in reducing SARS-CoV-2 pathogenesisIn silico 연구는 SARS-CoV-2 발병기전을 감소시키는 구조적으로 다양한 식물 2차 대사산물의 역할을 입증했습니다.Article Published on 2020-11-252022-08-31 Journal: Scientific Reports [Category] SARS, 신약개발, 치료제, [키워드] active site anthocyanidins anti-SARS-CoV-2 binding Bioavailability Computational biology and bioinformatics COVID-19 Data analysis Drug discovery drug-likeness enzyme Enzymes evidenced flavonoids flavonol glycoside host cell in vitro in vivo Interaction Ligand lower binding energy molecular docking natural Occurrence plant plants platform present protease Protein provide PSM Receptor binding domain recorded reducing Replication researcher Result RNA polymerase RNA-dependent RNA polymerase SARS-CoV-2 pathogenesis Secondary Metabolite secondary metabolites selected Serine silico study small molecule Small molecules target proteins transformation transmembrane serine protease unique Viral viral pathogenesis Viral RNA viral RNA-dependent RNA polymerase viral spike viral spike protein [DOI] 10.1038/s41598-020-77602-0 PMC 바로가기 [Article Type] Article
Evolution and pathogenicity of H6 avian influenza viruses isolated from Southern China during 2011 to 2017 in mice and chickensArticle Published on 2020-11-252023-05-31 Journal: Scientific Reports [Category] Fulltext, 조류인플루엔자, [키워드] Influenza virus viral evolution viral pathogenesis [DOI] 10.1038/s41598-020-76541-0 PMC 바로가기 [Article Type] Article
Kallikrein 13 serves as a priming protease during infection by the human coronavirus HKU1Kallikrein 13은 인간 코로나바이러스 HKU1에 감염되는 동안 프라이밍 프로테아제 역할을 합니다.Research Article Published on 2020-11-242022-09-25 Journal: Science Signaling [Category] 유전자 메커니즘, 진단, [키워드] blocked cause Cell cell culture system cell line cells cellular cleavage cleave cleaved complex Coronaviral coronavirus demonstrated determine distribution effort elements enzyme facilitate HCoV-HKU1 help HKU1 Host host receptor Human human airway epithelial in vitro model Infection Interaction Kallikrein KLK13 mechanism mild respiratory overexpression prevalent primary determinant priming protease Protein receptor regulate required Respiratory disease respiratory epithelial cell S protein S1/S2 SARS-CoV-2 specificity target cells the spike protein These data tissue Transmission viral entry viral pathogenesis viral replication viral S protein virus [DOI] 10.1126/scisignal.aba9902 PMC 바로가기 [Article Type] Research Article
Computational Analysis of Targeting SARS-CoV-2, Viral Entry Proteins ACE2 and TMPRSS2, and Interferon Genes by Host MicroRNAsCommunication Published on 2020-11-162022-10-31 Journal: Genes [Category] COVID-19, SARS, [키워드] 3′-UTR 5′-UTR ACE2 acute respiratory syndrome Algorithm binding site biological plausibility Biomarkers cell lines Combination coronavirus coronavirus disease COVID-19 Critical dataset global pandemic health care systems host miRNA identify IFN IFN-α infected cells interactions Local mechanism microRNA miR-29a miRNA miRNA profiling miRNAs mRNA transcript ORF potential therapeutic target predict predicted proteins ACE2 provide Rapid regulated Regulatory responsible RNA RNA viruses SARS-CoV-2 SARS-CoV-2-infected cell Spread targeting the interferon the SARS-CoV-2 genome TMPRSS2 upstream viral entry viral pathogenesis virus [DOI] 10.3390/genes11111354 PMC 바로가기 [Article Type] Communication
In silico and in vitro studies reveal complement system drives coagulation cascade in SARS-CoV-2 pathogenesisResearch Article Published on 2020-11-112022-10-31 Journal: Computational and Structural Biotechnology Journal [Category] COVID-19, [키워드] Abstract AKT1 Analysis approach ARDS Cancer candidate cascades Cell changes Coagulation coagulation cascade complement Complication computational analysis COVID-19 Critical Critical case Cytokines storm degranulation degree downstream driver expression Fold change Gene ontology globe host proteins Huh7 IFN-I in silico in vitro in vitro study include Infection inhibit intravascular coagulation IRAK1 IRF3 IRF7 ISG ITGAM KEGG pathway analysis knowledge lack MAPK signaling MAPK1 MAPK1/MAPK3 MAPK3 MAVS mechanism medical intervention mitigate MOST neutrophil degranulation overlap pathway Pathways PD-L1 platelet activation predicted Protein proteomic public health emergency receptor signaling Regulatory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis severe COVID-19 patients Signaling signaling pathway similarity Spread SRC STOM therapeutic targeting thrombosis thrombotic TNF TP53 Traf6 Transcriptome up-regulated VAMP8 viral infection viral pathogenesis [DOI] 10.1016/j.csbj.2020.11.005 PMC 바로가기 [Article Type] Research Article
Perversely expressed long noncoding RNAs can alter host response and viral proliferation in SARS-CoV-2 infectionResearch Article Published on 2020-10-272022-10-31 Journal: Future Virology [Category] COVID-19, [키워드] Alter Analysis analyzed Cell cellular COVID-19 deregulated determine differentially expressed Differentially expressed genes disease expressed Gene Expression host response identify immune response in viral infections involved lncRNA long noncoding RNA lung epithelial cell material miRNA outcome proliferation protein-coding genes Regulation RNA-seq dataset SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 proteins survival viral infection viral pathogenesis viral proliferation [DOI] 10.2217/fvl-2020-0188 PMC 바로가기 [Article Type] Research Article
Phytochemicals from Selective Plants Have Promising Potential against SARS-CoV-2: Investigation and Corroboration through Molecular Docking, MD Simulations, and Quantum Computations선택적 식물의 파이토케미컬은 SARS-CoV-2에 대한 유망한 잠재력을 가지고 있습니다: 분자 도킹, MD 시뮬레이션 및 양자 계산을 통한 조사 및 확증Research Article Published on 2020-10-132022-09-10 Journal: BioMed Research International [Category] 치료제, [키워드] acute respiratory syndrome Analysis analyzed association Beta Beta coronaviruses binding binding affinity Care caused Compound compounds Coronaviridae Coronavirus-2 docked glycoside Helicase in viral in vitro in vivo Infection inhibitor investigation MERS methyltransferase Middle East Middle East respiratory syndrome molecular molecular dynamics molecular dynamics simulations Nidovirale Nidovirales nonstructural protein nonstructural proteins nsp13 pandemic Pathogenesis performed pharmacological phytochemical plant positive Potential Protein protocols quantum reactivity reported respiratory Rhamnetin Ribonucleic acid SARS-CoV-2 screened Sesquiterpene Severe acute respiratory syndrome single-stranded subject syndrome these compound these compounds these viruses treat Vaccine Viral viral pathogenesis virus viruses Wuhan Wuhan, China [DOI] 10.1155/2020/6237160 PMC 바로가기 [Article Type] Research Article