Whole-genome sequencing reveals host factors underlying critical COVID-19
전체 게놈 시퀀싱은 중요한 COVID-19의 기저에 있는 숙주 요인을 밝힙니다
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Journal: Nature [Category] COVID19(2023년), MERS, SARS, 바이오마커, 변종, 유전자 메커니즘, 임상, 진단, 치료기술, 치료제,
Journal: Nature [Category] COVID19(2023년), MERS, SARS, 바이오마커, 변종, 유전자 메커니즘, 임상, 진단, 치료기술, 치료제,
[키워드] Adhesion Molecule
Antigen
association
associations
ATP11A
BCL11A
caused
CD209
Coagulation
coagulation factor
Colocalization
Control
COVID-19
Critical
Critical care
Critical disease
Critical illness
Critically ill
disease
disease severity
Evidence
expression
Factor
failure
FUT2
Gene Expression
Genetic variation
genetics
Genome
genomes
GenOMICC
Hospitalization
Host
ICAM5
identify
IL10RB
Immune-mediated
increased expression
independent
individual
infection with SARS-CoV-2
inflammatory lung injury
influence
interferon
intravascular coagulation
involved
leucocyte
life-threatening
Lung injury
mechanism
mechanisms
membrane
mendelian randomization
MUC1
mucin
myeloid cell
pathophysiology
PLSCR1
provide
pulmonary inflammation
reduced
replicate
reveal
SELE
Sequencing
significantly
Support
targets
transcriptome-wide
underlying disease
variant
variants
Viral
viral replication
whole-genome sequencing
[DOI] 10.1038/s41586-022-04576-6 PMC 바로가기 [Article Type] Article
[DOI] 10.1038/s41586-022-04576-6 PMC 바로가기 [Article Type] Article