The PDZ-binding motif of the avian NS1 protein affects transmission of the 2009 influenza A(H1N1) virusArticle Published on 2014-06-202023-06-24 Journal: Biochemical and Biophysical Research Communication [Category] 신종인플루엔자, [키워드] influenza A virus interferon NS1 protein PDZ-binding motif Transmission [DOI] 10.1016/j.bbrc.2014.04.132
Structural Basis for the Ubiquitin-Linkage Specificity and deISGylating Activity of SARS-CoV Papain-Like ProteaseResearch Article Published on 2014-05-222022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] 3D structure abrogated activate activated activity acute respiratory syndrome amino acid residue B-cell Basis binding cleaving complex coronavirus distal domain DUB ENCODE enzyme function Genome help higher affinity highlight Host host cell hydrolysis identify in viral inhibited innate immune response interact Interaction interferon involved ISG15 mechanism MERS Middle East molecular mutant mutated NFκB nuclear Papain-like protease Pathogenesis PLPro polyprotein post-translational modification Protease activity Protein Proteins provide reduced required residue residues respiratory reveal SARS virus SARS-CoV short circuit signaling molecule signaling pathway significantly similar study specificity stimulated substrate substrates thumb unique viral replication virus was determined X-ray [DOI] 10.1371/journal.ppat.1004113 PMC 바로가기 [Article Type] Research Article
High-dose dietary zinc oxide mitigates infection with transmissible gastroenteritis virus in pigletsResearch Article Published on 2014-03-282022-10-28 Journal: BMC veterinary research [Category] Coronavirus, MERS, [키워드] added addition Apoptosis cause chloride Concentration control group coronavirus cytokine decrease detectable diarrhea Diseases down-regulation Electrophysiology epithelial evaluate the effect fecal Fecal consistency Final gastroenteritis group groups humoral immune response IFN in vivo incidence Infection interferon intestinal intestinal tract mechanism mitigate Morphometry mucosal immune OAS oral physiological PROTECT protective effect receiving reduce response Result secretion serum antibody response severity shown SLC30A1 SLC30A5 SLC39A4 stimulate TGEV three group transmissible gastroenteritis virus villus virus virus infection was performed Zinc zinc oxide Zinc transporters [DOI] 10.1186/1746-6148-10-75 PMC 바로가기 [Article Type] Research Article
SARS coronavirus papain-like protease inhibits the type I interferon signaling pathway through interaction with the STING-TRAF3-TBK1 complexResearch Article Published on 2014-03-142022-10-29 Journal: Protein & Cell [Category] Coronavirus, [키워드] activated Activation antagonistic antiviral activity complex component deubiquitinase develop disrupt domain elicit evade explain expression form host innate immunity IFN IFN response IKKε inhibit interact Interaction interferon IRF3 mechanism Papain-like protease pathway Phosphorylation physically PLPro previous study reduce regulate RIG-I robust SARS Coronavirus SARS-CoV signaling pathway STING-TRAF3-TBK1 complex suggested TBK1 TRAF3 Type I IFN type I interferon yielding [DOI] 10.1007/s13238-014-0026-3 PMC 바로가기 [Article Type] Research Article
Antiviral strategies for hepatitis E virusReview Published on 2014-02-012023-06-11 Journal: Antiviral Research [Category] E형 간염, Fulltext, [키워드] antiviral therapy hepatitis E virus Host factor inhibitor interferon ribavirin [DOI] 10.1016/j.antiviral.2013.12.005 PMC 바로가기 [Article Type] Review
Strain-specific innate immune signaling pathways determine malaria parasitemia dynamics and host mortalityArticle Published on 2014-01-282024-08-28 Journal: Microbial Cell Factories [Category] 말라리아, [키워드] interferon MAVS MDA5 phagocytosis rodent
Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational studyArticle Published on 2014-01-062023-06-14 Journal: International Journal of Infectious Diseases [Category] MERS, [키워드] interferon MERS-CoV Pegylated interferon ribavirin [DOI] 10.1016/j.ijid.2013.12.003 PMC 바로가기 [Article Type] Article
Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirusArticle Published on 2013-10-032023-06-14 Journal: The Journal of Infection [Category] Fulltext, MERS, [키워드] Antiviral coronavirus interferon Middle East mycophenolic acid ribavirin [DOI] 10.1016/j.jinf.2013.09.029 PMC 바로가기 [Article Type] Article
Cutthroat trout virus as a surrogate in vitro infection model for testing inhibitors of hepatitis E virus replicationArticle Published on 2013-10-012023-06-12 Journal: Antiviral Research [Category] E형 간염, [키워드] Antiviral Cutthroat trout virus hepatitis E virus interferon Pregnancy ribavirin [DOI] 10.1016/j.antiviral.2013.07.013
The antiviral activity of poly-γ-glutamic acid, a polypeptide secreted by Bacillus sp., through induction of CD14-dependent type I interferon responsesArticle Published on 2013-09-062023-06-15 Journal: Biomaterials [Category] MERS, [키워드] antiviral agent hepatitis C virus interferon Poly-γ-glutamic acid SARS Coronavirus TLR4 [DOI] 10.1016/j.biomaterials.2013.08.067 PMC 바로가기 [Article Type] Article