Peginterferon alpha-based therapy for chronic hepatitis B focusing on HBsAg clearance or seroconversion: a meta-analysis of controlled clinical trialsResearch Article Published on 2011-06-092023-06-02 Journal: BMC Infectious Diseases [Category] B형 간염, [키워드] HBsAg hepatitis B interferon lamivudine peginterferon [DOI] 10.1186/1471-2334-11-165 PMC 바로가기 [Article Type] Research Article
Identification and Characterization of Three Novel Small Interference RNAs That Effectively Down-Regulate the Isolated Nucleocapsid Gene Expression of SARS CoronavirusArticle Published on 2011-02-112022-10-30 Journal: Molecules [Category] Coronavirus, [키워드] analyzed Apoptosis cells characterization coding sequence conserved coronavirus different eGFP Evidence expression found function Gene Expression Host host cell identification IFNβ inhibitory effect innate immune responses Interference interferon Isolated isolates M gene N gene non-coding RNA novel Nucleocapsid gene nucleotide deletion post-transcriptionally Proinflammatory cytokine Protein reduce Region RNA RT-PCR SARS-CoV sequence sequence information significantly siRNA Substitution thought up-regulate [DOI] 10.3390/molecules16021544 PMC 바로가기 [Article Type] Article
Early gene expression events in ferrets in response to SARS coronavirus infection versus direct interferon-alpha2b stimulationArticle Published on 2010-10-282023-06-15 Journal: Virology [Category] MERS, [키워드] ferret Gene Expression interferon SARS [DOI] 10.1016/j.virol.2010.10.002 PMC 바로가기 [Article Type] Article
Small Interfering RNA Effectively Inhibits the Expression of SARS Coronavirus Membrane Gene at Two Novel Targeting SitesArticle Published on 2010-10-182022-10-30 Journal: Molecules [Category] Coronavirus, [키워드] analyzed blocked conserved coronavirus Critical demonstrated downregulate downregulated Effect eGFP expression Gene Expression information interferon isolate isolates M gene membrane Membrane gene novel nucleotide nucleotide substitution occur post-transcriptionally Protein qRT-PCR Quantitative Region RNA RNA molecule RT-PCR SARS-CoV SARS-CoV infection SARS-CoV M semi-quantitative sequence significantly siRNA Site Small interfering RNA targeting tested upregulation viral genome viral infection [DOI] 10.3390/molecules15107197 PMC 바로가기 [Article Type] Article
Cellular response to influenza virus infection: a potential role for autophagy in CXCL10 and interferon-alpha inductionResearch Article Published on 2010-07-172023-06-14 Journal: Cellular and Molecular Immunology [Category] Fulltext, 신종인플루엔자, [키워드] autophagy CXCL10 Influenza interferon [DOI] 10.1038/cmi.2010.25 PMC 바로가기 [Article Type] Research Article
SARS-CoV Pathogenesis Is Regulated by a STAT1 Dependent but a Type I, II and III Interferon Receptor Independent MechanismResearch Article Published on 2010-04-082022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] acute lung injury acute respiratory syndrome affecting alveolar inflammation ARDS Author BALB/c mice caused cell proliferation clinical disease coronavirus death demonstrated Dependent died Diffuse alveolar damage ENhance Epidemic evaluated highly pathogenic I, II independent Infected Infection innate immune innate immune response Innate immunity interferon interferon signaling knockout mice lack liver Lung disease Lung injury Lung pathology MA15 mechanism mice molecular mechanism Mortality Mouse models other tissue outcomes Pathogenesis Pathways Post-infection PROTECT Protein pulmonary fibrosis pulmonary lesion question receptor regulated respiratory respiratory virus SARS Coronavirus SARS pathogenesis SARS-CoV SARS-CoV infection severe severe disease Signaling spleen Stat1 the epidemic Type type I type III interferon viral pathogenesis virus virus pathogenesis virus titer Virus-host interaction viruses weight loss wildtype [DOI] 10.1371/journal.ppat.1000849 PMC 바로가기 [Article Type] Research Article
Dynamic Innate Immune Responses of Human Bronchial Epithelial Cells to Severe Acute Respiratory Syndrome-Associated Coronavirus InfectionResearch Article Published on 2010-01-152022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] 2B4 cell 2B4 cells Activation aggravate antiviral genes antiviral signaling bronchial bronchial epithelial cell calu-3 cells cellular cloned complementary complex coronavirus detected detrimental dynamic epithelial epithelial cell line event expression found functional growth highlight Host Human identify IFN-stimulated gene IFN-β IFN-λ Immune-mediated Infected Inflammatory cytokine Inflammatory mediators Inflammatory responses Innate interferon interferon regulatory factor ISGs limit lung epithelial cell Lungs nuclear pathology post infection Protein Replication respiratory response resulting SARS pathogenesis SARS-CoV SARS-CoV infection secreting severe Signaling Support target these cell triggered [DOI] 10.1371/journal.pone.0008729 PMC 바로가기 [Article Type] Research Article
Antagonism of Innate Immunity by Paramyxovirus Accessory ProteinsReview Published on 2009-12-282023-08-29 Journal: Viruses [Category] E형 간염, [키워드] Apoptosis Innate immunity interferon paramyxoviruses [DOI] 10.3390/v1030574 PMC 바로가기 [Article Type] Review
Type I interferon receptor-independent and -dependent host transcriptional responses to mouse hepatitis coronavirus infection in vivoResearch Article Published on 2009-08-032022-10-28 Journal: BMC Genomics [Category] Coronavirus, MERS, [키워드] Analysis Antiviral association BALB/c BALB/c mice Brain brains compared coronavirus Coronavirus infection correlated CoV CoV infection Culture days post infection demonstrated detected different differentially expressed effector expression profiling Fold change Gene Gene Expression gene expression profile Host transcriptional response identify IFN response IFN-inducible gene IFN-γ in vivo inducer Infected Infection infections interferon knowledge less MHV mice mouse hepatitis performed Profiling Protective protective role receptor response responses Result robust shown significantly Strains susceptibility susceptible tissue transcriptional responses Type type I Type I IFN type I interferon type II IFN Viral load virus were used while whole-genome [DOI] 10.1186/1471-2164-10-350 PMC 바로가기 [Article Type] Research Article
Applications of high-throughput genomics to antiviral research: Evasion of antiviral responses and activation of inflammation during fulminant RNA virus infectionArticle Published on 2009-04-162023-06-14 Journal: Antiviral Research [Category] Fulltext, 신종인플루엔자, [키워드] 1918 Influenza virus Ebola virus Filovirus Host response evasion Influenza interferon [DOI] 10.1016/j.antiviral.2009.04.004 PMC 바로가기 [Article Type] Article