Evolving geographic diversity in SARS-CoV2 and in silico analysis of replicating enzyme 3CL pro targeting repurposed drug candidates
Research
[키워드] 3CL pro
acute respiratory syndrome
African
analysed
anti-malarial drug
Anti-viral
bat-CoV
Clustal Omega
collected
Complete
Compound
cysteine protease
database
drug candidate
enzyme
fatality
Genetic
Genome
genomic sequence
GISAID
high mutation rate
host genome
host immunity
identity
implication
in silico analysis
in silico approaches
in-depth analysis
individual
infection rate
inhibitor
initiative
Interaction
isolate
Local
Multiple
mutagenic
mutations
occurred
pandemic
Pandemics
pangolin-CoV
pathogen
pathogenicity
pharmacological
populations
provide
recurrent mutation
reference genome
regulate
reported
Repurposed drug
Result
RNA
SARS Coronavirus
SARS-CoV-2
SARS-CoV-2 genome
SARS-CoV-2 infected patients
SARS-CoV2
sequence
South
South America
the SARS-CoV-2
unique
viral genome
viral pathogenicity
viral replication
viral sequence
was collected
was used
Wuhan
[DOI] 10.1186/s12967-020-02448-z PMC 바로가기 [Article Type] Research
[DOI] 10.1186/s12967-020-02448-z PMC 바로가기 [Article Type] Research