Monoclonal gammopathy of undetermined significance and risk of infections: a population-based studyOriginal Articles and Brief Reports Published on 2012-06-012024-09-04 Journal: Haematologica [Category] 대상포진, [키워드] Bacteria infections monoclonal gammopathy of undetermined significance Multiple myeloma virus [DOI] 10.3324/haematol.2011.054015 PMC 바로가기 [Article Type] Original Articles and Brief Reports
IFN-γ protects from lethal IL-17 mediated viral encephalomyelitis independent of neutrophilsResearch Published on 2012-05-292022-10-30 Journal: Journal of Neuroinflammation [Category] Coronavirus, [키워드] affecting Autoimmune blockade CD4 CD4+ T cells Central nervous system clinical consequence CNS compared complex coronavirus cytokine Demyelination detrimental disease downstream effector molecule Encephalomyelitis expression Factor feedback loops GM-CSF IFN-γ IFN-γ IL-17 independent Infected inflammatory condition inflammatory disease Interaction mechanism memory mice morbidity Mortality murine Neurotropic coronavirus neutrophil neutrophil infiltration Neutrophils not express pathogenic positive PROTECT provided recipient reduced reducing relative contribution rescued response Result survival T cell T cells Th1 Th17 Th17 cell tissue damage Transcription transcriptional regulation transfer upregulation virus was used wild-type [DOI] 10.1186/1742-2094-9-104 PMC 바로가기 [Article Type] Research
CD200 Receptor Controls Sex-Specific TLR7 Responses to Viral InfectionResearch Article Published on 2012-05-172022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] absence Activation administration anti-viral response Author blocker Cancer CD200 clearance clinical trial Control dependent on determine determined different disease disease symptom ENhance Factor female female patient females Host humans Hypothesis IFN immune immune inhibitory immune response immune system immunological impair implication IMPROVE in vitro in vivo Infection influenza A virus Influenza virus inhibit inhibitory inhibitory signal lack Ligand lung MHV mice microbial infection mouse hepatitis neutrophil observé outcome overactive pathogen pathology pathway predict Prevent provided receptor receptors Release reported response Sex Sex difference Signaling supported suppresse therapeutic targeting therapeutic use threshold TLR7 Treatment Type I IFN type I interferon viral clearance viral infection virus virus infection [DOI] 10.1371/journal.ppat.1002710 PMC 바로가기 [Article Type] Research Article
Mechanism of Nucleic Acid Unwinding by SARS-CoV HelicaseResearch Article Published on 2012-05-152022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] acid base-pair carried catalytic demonstrated determined DNA double-stranded double-stranded RNA dsDNA dsRNA Efficiency ENhance enzyme experimental evidence Helicase hydrolysis IMPROVE kinetic analysis mechanism non-structural protein Nsp12 nsp13 nucleic acid nucleotide RdRP respiratory RNA synthesis RNA-dependent RNA polymerase SARS-CoV severe viral replication virus was used [DOI] 10.1371/journal.pone.0036521 PMC 바로가기 [Article Type] Research Article
Regulatory T Cells in Arterivirus and Coronavirus Infections: Do They Protect Against Disease or Enhance it?Review Published on 2012-05-152022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] Activation adaptive Against antigenic arterivirus, porcine reproductive and respiratory syndrome virus CD25 CD28 CD4 CD8 Cell cells chronic inflammation Coronaviral coronavirus cytokine described develop disease Express expression form hallmark homeostasis host response IL-10 Immune homeostasis immune response immune tolerance induction Infection interleukin 2 lactate dehydrogenase lactate dehydrogenase-elevating virus maintain mean mouse hepatitis virus natural Other Pathogenesis PROTECT receptor Regulatory Regulatory T cell reproductive responsible subset syndrome T cell T cell subset T helper TGF-β the disease transcription factor Type viral persistence virus [DOI] 10.3390/v4050833 PMC 바로가기 [Article Type] Review
Protection conferred by a recombinant Marek’s disease virus that expresses the spike protein from infectious bronchitis virus in specific pathogen-free chickenResearch Published on 2012-05-042022-10-28 Journal: Virology Journal [Category] Coronavirus, MERS, [키워드] Clinical sign develop disease effective expresse Genome IBV IBV infection Infectious Bronchitis Virus isolate Marek’s disease virus Mild Mortality predominant Prevent protection Protein Result Specific specific pathogen-free SPF Spike protein strain the S1 subunit the spike protein Vaccine virulent virus [DOI] 10.1186/1743-422X-9-85 PMC 바로가기 [Article Type] Research
A Single Polar Residue and Distinct Membrane Topologies Impact the Function of the Infectious Bronchitis Coronavirus E ProteinResearch Article Published on 2012-05-032022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] activities adopted affected Antiviral strategies Author coronavirus correlated defined different disrupt disrupting domain E protein examined found function functions Golgi Host hydrophobic IBV identify Impact implicated in vitro independent infected cells Infection infectious Infectious Bronchitis Virus Infectious virus less mapped mechanism of action membrane membrane protein mutant occur Particle Particles predicted promote Protein reported required residue secretory pathway Substitution thought Topology transmembrane virion assembly virus [DOI] 10.1371/journal.ppat.1002674 PMC 바로가기 [Article Type] Research Article
Post-Transcriptional Control of Type I Interferon Induction by Porcine Reproductive and Respiratory Syndrome Virus in Its Natural Host CellsReview Published on 2012-05-022022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] Control defined dsRNA molecules gastroenteritis host cell inducer induction inhibit interfere less natural post-transcriptional regulation PRRSV Regulation reproductive respiratory syndrome TGEV translational translational control Type type I interferon virus [DOI] 10.3390/v4050725 PMC 바로가기 [Article Type] Review
Suppression of feline coronavirus replication in vitro by cyclosporin AResearch Published on 2012-04-302022-10-28 Journal: Veterinary Research [Category] Coronavirus, [키워드] activated bind cause Cell cells cellular changed coronavirus Coronavirus replication cyclosporin cyclosporin A Factor FK506 FKBP growth immunosuppressive agent in vitro in vivo incurable infectious inhibited inhibitory effect not affect nuclear pathway Protein Replication suppression T-cell target Treatment viability virus [DOI] 10.1186/1297-9716-43-41 PMC 바로가기 [Article Type] Research
Co-circulation of Four Human Coronaviruses (HCoVs) in Queensland Children with Acute Respiratory Tract Illnesses in 2004Article Published on 2012-04-232022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] aetiology age ARI assay assigned children circulation clinical impact clinical severity score compared coronavirus detected develop diagnostic different HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 Human infectious Patient peaked positive random Real-time PCR reduce respiratory Respiratory illness respiratory specimen respiratory syncytial virus respiratory virus RT-rtPCR Screening serology Severity Score specimen tested tract transcriptase virus were used [DOI] 10.3390/v4040637 PMC 바로가기 [Article Type] Article