Identification of a novel conserved HLA-A*0201-restricted epitope from the spike protein of SARS-CoVResearch article Published on 2009-12-032022-10-27 Journal: BMC Immunology [Category] Coronavirus, [키워드] acute respiratory syndrome analyzed assays autologous binding Candidates Cell-mediated immune responses cleavage conserved coronavirus CoV CTL dendritic cell different Donor eight epitope Ex vivo full-length S protein glycoprotein healthy help identification IFN-γ immunized immunized mice immunopathology lysed mechanism Pathogenesis PBL peptide peptides Plasmid predict processed Protein Region released Result S protein SARS-CoV SARS-CoV infection sequence target cell tested the S protein the spike protein transgenic mice virus virus clearance [DOI] 10.1186/1471-2172-10-61 PMC 바로가기 [Article Type] Research article
Respiratory Disease in Adults during Pandemic (H1N1) 2009 Outbreak, ArgentinaLetter to the Editor Published on 2009-12-012023-06-08 Journal: Emerging Infectious Diseases [Category] Fulltext, 신종인플루엔자, [키워드] Argentina expedited H1N1 Human Influenza Latin America letter virus [DOI] 10.3201/eid1512.091062 PMC 바로가기 [Article Type] Letter to the Editor
Cleavage of the SARS Coronavirus Spike Glycoprotein by Airway Proteases Enhances Virus Entry into Human Bronchial Epithelial Cells In VitroResearch Article Published on 2009-11-172022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] 16HBE ACE2 ACE2 binding Activation acute respiratory syndrome against SARS-CoV airway Amino acid Analysis arginine residue bronchial bronchial epithelial cell cell entry Chromatography cleavage cleaved coronavirus demonstrated dependent on different Efficacy Efficiency exhibited expand expressing expression Extracellular finding full-length glycoprotein host cell HPLC Human implication in vitro investigated lack liquid mechanism molecular basis mutant not affect performance potential therapeutic agent protease Proteases Protein R667 R797 Receptor binding regulate Respiratory system S-protein SARS-CoV SARS-CoV infection Sequencing shown spike susceptibility susceptible Treatment trimer trypsin viral entry viral envelope virus virus entry [DOI] 10.1371/journal.pone.0007870 PMC 바로가기 [Article Type] Research Article
Specific real-time reverse transcription-polymerase chain reaction for detection and quantitation of turkey coronavirus RNA in tissues and feces from turkeys infected with turkey coronavirusArticle Published on 2009-11-142022-11-01 Journal: Journal of virological methods [Category] Coronavirus, MERS, [키워드] 3′ end acute enteritis amplified antibody assays average Bacteria base-pair cause collected conducted coronavirus coronavirus RNA Critical detected determine Diagnosis different DPI economic loss FAM fecal Fecal sample fluorescent highest IFA immunofluorescence indicated Infected Infection inoculated interval intestine Other PCR primer positive primer probe progression quantitation Rapid reached real-time RT-PCR reporter RNA sensitivity serial dilution Specific specificity spike gene Swab swabs TaqMan probe the disease tissue Trial trials Turkey Turkey coronavirus viral genome Viral RNA viral RNA load virus was performed [DOI] 10.1016/j.jviromet.2009.11.012 PMC 바로가기 [Article Type] Article
MicroRNome Analysis Unravels the Molecular Basis of SARS Infection in Bronchoalveolar Stem CellsResearch Article Published on 2009-11-132022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] ACE2 Activation acute infectious disease acute respiratory syndrome Basis bronchoalveolar caused CD45 Cell cellular miRNA complex interaction coronavirus SARS-CoV Data analysis Deterioration develop diagnostic Disease progression downregulated downregulation enrichment analysis epithelial evade Factors host cell host–virus interaction immune Infection inflammatory chemokines interact knowledge lung lung failure lung tissue marker microRNA miRNA miRNAs molecular mechanism Mortality observation pathway Protein target pulmonary fibrosis Replication reveal SARS-CoV SARS-CoV infection severe spike Stage STEM stem cell subset suppress target target cell the SARS epidemic Transmission viral genome Viral transmission virus [DOI] 10.1371/journal.pone.0007837 PMC 바로가기 [Article Type] Research Article
A Protective Role for ELR+ Chemokines during Acute Viral EncephalomyelitisResearch Article Published on 2009-11-062022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] abrogated absence acute viral infection Alter antibody Author blocking Blood Brain Central nervous system characterized chemokine Chemokine receptor chemotaxis clinical outcomes CNS compensatory mechanism consequence contribute CXCL1 CXCL2 CXCL5 CXCR2 Defense defined directional Encephalitis Encephalomyelitis Evidence expressed expressing expression facilitate functional highlight Host impair in vitro increased expression indicated Infection infiltration Inflammatory Injury inoculation involved leukocytes Ligand lymphocyte mice microbial infection Migration modulate Mortality mouse hepatitis virus myeloid cells neurotropic neutralization neutrophil Neutrophils pathogen poliomyelitis proinflammatory receptor recruitment reduced reduction required role shown Signaling survived T cell responses T cells transcript viral clearance viral infection viral replication viral-induced virus was determined [DOI] 10.1371/journal.ppat.1000648 PMC 바로가기 [Article Type] Research Article
Evasion by Stealth: Inefficient Immune Activation Underlies Poor T Cell Response and Severe Disease in SARS-CoV-Infected MiceResearch Article Published on 2009-10-232022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] activate activated Activation Adaptive immune response allergic alveolar macrophage animal model Anti-viral Antigen Author BALB/c mice caused characterized correlated CoV dendritic cell dendritic cells deplete develop DLN draining lymph node Epidemic feature Human human disease human population humans immune response individual inefficient Infected Infection inhibitory inhibitory effect initial Liposome lung lymphopenia MA15 Macrophage mice morbidity and mortality mouse-adapted SARS-CoV Novel coronavirus occurred Patient Poor Prevent prolonged virus persistence PROTECT respiratory Respiratory disease response severe severe disease severe respiratory disease T cell response T cells Therapies TLR3 Toll-like receptor transfer treated virus virus clearance virus excretion virus-specific T cell [DOI] 10.1371/journal.ppat.1000636 PMC 바로가기 [Article Type] Research Article
The Replicase Gene of Avian Coronavirus Infectious Bronchitis Virus Is a Determinant of PathogenicityResearch Article Published on 2009-10-092022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] accessory gene avirulent cell tropism Complete demonstrated determinant dominant Genome IBV in vitro Infectious Bronchitis Virus M41 pathogenicity replaced replicase S gene virulence virulent virus [DOI] 10.1371/journal.pone.0007384 PMC 바로가기 [Article Type] Research Article
RNase L Mediated Protection from Virus Induced DemyelinationResearch Article Published on 2009-10-022022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] absence Affect alteration ameliorated Anti-viral antiviral activity antiviral molecules Apoptosis apoptotic cell apoptotic cells Author Brain Cell Central nervous system characterized CNS coronavirus Coronavirus infection Critical deficiency Degradation Demyelination dependent on early Encephalitis Evidence expression foci function Host IFN-α/β immune in viral Increased induced induction of apoptosis Infected Infection Infectious virus infiltrating inhibiting Intervention majority manifested mechanism Mediated mice microglia mitigate morbidity morbidity and mortality mouse hepatitis virus neurodegeneration neuronal infection neurotropic not affect pathology pathway phenotype prevented proinflammatory PROTECT protection protective role recent reduce reflected RL RNA RNA degradation RNase severity Spread sustained tissue tissue damage translation type I interferon unique variant viral control viral replication viral spread viral tropism virus without affecting [DOI] 10.1371/journal.ppat.1000602 PMC 바로가기 [Article Type] Research Article
Avian influenza virus, Streptococcus suis serotype 2, severe acute respiratory syndrome-coronavirus and beyond: molecular epidemiology, ecology and the situation in ChinaArticles Published on 2009-09-272022-10-29 Journal: Philosophical Transactions of the Royal Society B: [Category] Coronavirus, Fulltext, 조류인플루엔자, [키워드] addition Asia Avian Influenza Bacteria caused China coronavirus disease EHEC Escherichia coli expand fatality H5N1 highly pathogenic Host host range human pathogen implication infect Infection Influenza virus Isolation mammalian Molecular epidemiology occur outbreak pathogen pathogenicity PRRSV reproductive SARS-CoV serotype severe disease Shock Spread Streptococcus Streptococcus suis subsequent syndrome variant virus viruses zoonotic zoonotic pathogens zoonotic threat [DOI] 10.1098/rstb.2009.0093 PMC 바로가기 [Article Type] Articles