Inducible Bronchus-Associated Lymphoid Tissue Elicited by a Protein Cage Nanoparticle Enhances Protection in Mice against Diverse Respiratory VirusesResearch Article Published on 2009-09-232022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] accelerate accelerated antibody production Antigen appear Asymptomatic B cell CAGE cause CD4+ T cell clearance described destruction develop different disparate dose ENhance finding functional Host immune response immune response immune responses Immune-mediated Immunity independent Infection Inflammation influenza viruses inherent less limit lung lung damage Lymphoid tissue mechanisms morbidity nanoparticle novel virus pathogen Primary infection primary viral infection protection protective immune response Protein pulmonary viral recruitment Replication respiratory respiratory virus Safe SARS-coronavirus significant decrease significantly significantly increased specificity survival Treatment Vaccination strategies viral antigens viral clearance virus [DOI] 10.1371/journal.pone.0007142 PMC 바로가기 [Article Type] Research Article
Distant Relatives of Severe Acute Respiratory Syndrome Coronavirus and Close Relatives of Human Coronavirus 229E in Bats, GhanaResearch Published on 2009-09-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, [키워드] 229E bat bats common cold virus Concentration coronavirus CoV CoVs detected Distant Fecal sample Ghana Hipposidero human coronavirus hypothese molecular clock morphology Prevalence relative Research respiratory RNA severe Severe acute respiratory syndrome tested virus viruses [DOI] 10.3201/eid1509.090224 PMC 바로가기 [Article Type] Research
Reverse genetic characterization of the natural genomic deletion in SARS-Coronavirus strain Frankfurt-1 open reading frame 7b reveals an attenuating function of the 7b protein in-vitro and in-vivoResearch Published on 2009-08-242022-10-28 Journal: Virology Journal [Category] Coronavirus, MERS, [키워드] Bacterial caused cDNA Cell Cell culture cells changes in chromosome cleavage cloned compared contributed deleted downstream early phase explain Frame full-length protein Genetic Genome genomic hamster identify In-vitro induction of apoptosis Infection Infectious virus inoculated interferon beta intranasally lung observation ORF outbreak over-expressed parental Patient plaque forming unit promoter Protein prototype virus reconstructed replicate replicative reveal RNA SARS-CoV secretion Spread strain Strains suggested supernatant T7 RNA polymerase the SARS epidemic transcribed transfection transmembrane domain type I interferon variant Vero cells Viral RNA virulence virus virus isolate virus replication virus RNA [DOI] 10.1186/1743-422X-6-131 PMC 바로가기 [Article Type] Research
Type I interferon receptor-independent and -dependent host transcriptional responses to mouse hepatitis coronavirus infection in vivoResearch Article Published on 2009-08-032022-10-28 Journal: BMC Genomics [Category] Coronavirus, MERS, [키워드] Analysis Antiviral association BALB/c BALB/c mice Brain brains compared coronavirus Coronavirus infection correlated CoV CoV infection Culture days post infection demonstrated detected different differentially expressed effector expression profiling Fold change Gene Gene Expression gene expression profile Host transcriptional response identify IFN response IFN-inducible gene IFN-γ in vivo inducer Infected Infection infections interferon knowledge less MHV mice mouse hepatitis performed Profiling Protective protective role receptor response responses Result robust shown significantly Strains susceptibility susceptible tissue transcriptional responses Type type I Type I IFN type I interferon type II IFN Viral load virus were used while whole-genome [DOI] 10.1186/1471-2164-10-350 PMC 바로가기 [Article Type] Research Article
Measles control – Can measles virus inhibitors make a difference?Review Published on 2009-08-012023-05-25 Journal: Curr Opin Investig Drugs [Category] Fulltext, 홍역, [키워드] Antiviral drug eradication measles Vaccine virus PMC 바로가기 [Article Type] Review
Structure and Inhibition of the SARS Coronavirus Envelope Protein Ion ChannelResearch Article Published on 2009-07-102022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] 2003 acute respiratory syndrome affecting alteration Anti-viral drugs antiviral strategy Author binding site C-terminal Cell channel characterized common cold coronavirus coronavirus protein described determined distribution drug design E protein embryonic kidney envelope envelope protein event expressed expressing feature form found full length HEK-293 Human humans in vitro inactivation infect inhibited inhibition Ion lethal disease mammalian cell mammals membrane Mild morphology N-terminal NMR pandemic Pathogenesis pharmacological target platform produced Protein Proteins provide reduced reported responsible SARS-CoV SARS-CoV E shown significantly Structure supported transmembrane domain Validity variety viral envelope viral pathogen viral replication virion virus viruses [DOI] 10.1371/journal.ppat.1000511 PMC 바로가기 [Article Type] Research Article
Genetically Diverse Coronaviruses in Wild Bird Populations of Northern EnglandDispatch Published on 2009-07-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, [키워드] Analysis Bird bronchitis cause coronavirus costly detected dispatch England Epidemiology IBV Infectious bronchitis PCR Population related respiratory viral disease virus viruses wild birds zoonoses [DOI] 10.3201/eid1507.090067 PMC 바로가기 [Article Type] Dispatch
Chinese-like Strain of Porcine Epidemic Diarrhea Virus, ThailandDispatch Published on 2009-07-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, [키워드] Analysis Chinese clade dispatch epidemic diarrhea Genotype Infection isolate Molecular epidemiology outbreak pathology PEDV Porcine epidemic diarrhea strain Thailand virus [DOI] 10.3201/eid1507.081256 PMC 바로가기 [Article Type] Dispatch
Studies on membrane topology, N-glycosylation and functionality of SARS-CoV membrane proteinResearch Published on 2009-06-182022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] acute respiratory syndrome Amino acid Analysis biochemical C-terminal Cell culture conserved coronavirus Coronaviruses ectodomain endodomain ERGIC expressing found functional glycosylated Golgi complex immunofluorescence immunogenic Interaction M protein membrane membrane protein N-glycosylation N-glycosylation site N-terminal recruitment SARS-CoV SARS-CoV M Surface glycoprotein Topology transmembrane transmembrane domain Viral particles viral spike protein virion virus [DOI] 10.1186/1743-422X-6-79 PMC 바로가기 [Article Type] Research
Toll-like receptors, chemokine receptors and death receptor ligands responses in SARS coronavirus infected human monocyte derived dendritic cellsResearch Article Published on 2009-06-082022-10-28 Journal: BMC Immunology [Category] Coronavirus, Fulltext, MERS, [키워드] 2003 Apoptosis biological significance Blood CCR chemokine Chemokine receptor compared DC DCs death dendritic cell explain expression Fa facilitate Gene Gene Expression Immune escape induce Infected Infection involved Ligand lung infiltration lymph nodes lymphocyte lymphoid mechanism Migration modulate monocyte outbreak provide receptor reported response Result SARS Coronavirus SARS patients SARS-CoV severity significantly TLRs Toll-like receptor Toll-like receptors TRAIL unique upregulation virus [DOI] 10.1186/1471-2172-10-35 PMC 바로가기 [Article Type] Research Article