Outbreak analysis with a logistic growth model shows COVID-19 suppression dynamics in ChinaResearch Article Published on 2020-06-292022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] Analysis average China COVID-19 growth increase in initial Isolation Logistic measure Measures Novel coronavirus occurred outbreak parameter peaked reported SARS-CoV2 sick social distancing measures the disease the epidemic virus virus growth [DOI] 10.1371/journal.pone.0235247 PMC 바로가기 [Article Type] Research Article
Overview: Systemic Inflammatory Response Derived From Lung Injury Caused by SARS-CoV-2 Infection Explains Severe Outcomes in COVID-19Immunology Published on 2020-06-262022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] ACE2 Activation acute lung injury acute phase response acute respiratory distress Adhesion Molecule alveolar macrophage ARDS Bisphosphonates Blood Bone marrow Cell Combination COVID-19 CSS cytokine Cytokine storm syndrome decrease develop dissemination Endothelium expression Factors fibrinogen IL-1β IL-6 immature Impact increase infiltration of neutrophil Inflammation Inflammatory inflammatory monocytes Intervention Kallikrein-kinin system knowledge lung lung epithelial cell Lung infection Lung injury Monocytes MOST patients Platelets pro-thrombotic proinflammatory cytokines reducing renin-angiotensin system response SARS-CoV-2 SARS-CoV2 SARS-CoV2 infection severe COVID-19 stimulate syndrome systemic systemic inflammation TNF VEGF [DOI] 10.3389/fimmu.2020.01626 PMC 바로가기 [Article Type] Immunology
GSK-3 Inhibition as a Therapeutic Approach Against SARs CoV2: Dual Benefit of Inhibiting Viral Replication While Potentiating the Immune ResponseImmunology Published on 2020-06-262022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, MERS, SARS, [키워드] adaptive Against Analysis Anti-viral CD8+ CD8+: T lymphocyte subsets connection conserved COVID COVID-19 CTL cytolytic drug ENhance function GSK-3 Hypothesis immune response information inhibit inhibition inhibitor knowledge limit mice N protein natural killer NK cell pandemic Phosphorylation protein sequences question reducing reduction in Replication residue response responses SAR SARS-CoV2 SARS-CoV2 infection Serine small molecule inhibitor T-cell T-Cells (or lymphocytes) the N protein Therapeutic approach therapeutic approaches therapy Vaccine viral (or virus) viral infection viral replication virus while [DOI] 10.3389/fimmu.2020.01638 PMC 바로가기 [Article Type] Immunology
New-Onset Seizure as the Only Presentation in a Child With COVID-19Neurology Published on 2020-06-252022-10-31 Journal: Cureus [Category] COVID-19, [키워드] 2019 novel coronavirus disease abnormality afebrile Atypical biochemical chest X-ray Child children clinical presentation coronavirus disease COVID-19 COVID-19 crisis CT scan Fever gastrointestinal complaints globe highlight Hispanic limits male medications New York observation Patient PCR pediatric pediatrics polymerase chain positive presentation profile radiological recognizing SARS-CoV2 Seizure Seizures [DOI] 10.7759/cureus.8820 PMC 바로가기 [Article Type] Neurology
Class A G Protein-Coupled Receptor Antagonist Famotidine as a Therapeutic Alternative against SARS-CoV2: An In Silico AnalysisArticle Published on 2020-06-242022-10-28 Journal: Biomolecules [Category] COVID-19, [키워드] administration Analysis antagonist Antiviral antiviral drugs Antiviral effect antiviral therapy approach binding affinity catalytic site class clinical trial Combination computational analysis contribute COVID-19 described disease drug effective Effectiveness Famotidine G protein-coupled receptor Gastroesophageal reflux HIV HIV protease inhibitor Human immunodeficiency virus Hydroxychloroquine in silico indicated inhibitors intravenous involved knowledge outcome pandemic parameter Patient pharmacokinetic pharmacological protease Proteases provided reached Replication repurposing respiratory retrospective SARS-CoV2 SARS-CoV2 infection Scientific community the United State therapeutic therapy Treatment virus replication [DOI] 10.3390/biom10060954 PMC 바로가기 [Article Type] Article
Evaluation of Protection Level, Respiratory Safety, and Practical Aspects of Commercially Available Snorkel Masks as Personal Protection Devices Against Aerosolized Contaminants and SARS-CoV2Article Published on 2020-06-192022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, SARS, [키워드] adaptation adaptor Against approved aspect benefit claimed comparable Complete concern Device effective end-tidal evaluated Face mask increase in initial Level limits Mask Masks media offer oxygen saturation pandemic performed personal protection devices physical physiological protection Protective reliability respiratory Result risk Safe Safety safety test SARS-CoV2 snorkel masks tested ventilator was performed [DOI] 10.3390/ijerph17124347 PMC 바로가기 [Article Type] Article
Three Decades of Interferon-β in Multiple Sclerosis: Can We Repurpose This Information for the Management of SARS-CoV2 Infection?Immunology Published on 2020-06-182022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] antiviral-activity Can immunoregulation Multiple multiple scleorsis (MS) SARS-CoV-2 SARS-CoV2 Type I IFN [DOI] 10.3389/fimmu.2020.01459 PMC 바로가기 [Article Type] Immunology
Impact of COVID-19 on Pediatric Asthma: Practice Adjustments and Disease BurdenArticle Published on 2020-06-172023-07-02 Journal: The journal of allergy and clinical immunology. In [Category] SARS, [키워드] adherence Asthma children Control COVID-19 COVID-19, Coronavirus disease 2019 IQR, interquartile range SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 SARS-CoV2 virus [DOI] 10.1016/j.jaip.2020.06.001 PMC 바로가기 [Article Type] Article
Virtual screening-driven drug discovery of SARS-CoV2 enzyme inhibitors targeting viral attachment, replication, post-translational modification and host immunity evasion infection mechanismsResearch Article Published on 2020-06-162023-06-15 Journal: Journal of biomolecular structure & dynamics [Category] MERS, SARS, [키워드] ADMET Antiviral COVID-19 fungal natural products molecular docking molecular dynamics SARS-CoV2 [DOI] 10.1080/07391102.2020.1776639 PMC 바로가기 [Article Type] Research Article
A potential role for Galectin-3 inhibitors in the treatment of COVID-19Cell Biology Published on 2020-06-152022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] acute respiratory syndrome Alpha anti-inflammatory effect coronavirus coronavirus disease COVID-19 COVID-19 patients Critical Cytokine release syndrome Cytokines domain effective elevated Evidence fatality galectin-3 global pandemic host cells host inflammatory response identify IL-6 implicated in vitro in vivo include inflammatory conditions inhibitor interleukin-6 mechanism morphology Necrosis outbreak patients recent reduce Research SARS-CoV2 shown Spike protein Standard of care systematic review the disease the spike protein therapy TNF-α Treatment variety World Health Organization [DOI] 10.7717/peerj.9392 PMC 바로가기 [Article Type] Cell Biology