An evaluation of COVID-19 serological assays informs future diagnostics and exposure assessmentArticle Published on 2020-07-062022-10-04 Journal: Nature Communications [Category] SARS, 진단, 치료기술, [키워드] antibody Antibody testing assays Characteristics correlated COVID-19 COVID-19 pandemic cut-off detect diagnostics eight ELISA functional global pandemic Immunoglobulin implementation Laboratory techniques and procedures Medical research outcome Population screening protective antibodies Receptor binding domain SARS CoV-2 SARS-CoV-2 selected serological Serological assay serology Severity of disease Stage Support variety viral infection Virus neutralization virus neutralizing antibodies [DOI] 10.1038/s41467-020-17317-y PMC 바로가기 [Article Type] Article
COVID-19 spurs wave of innovative diagnostics News Published on 2020-07-012022-10-05 Journal: Nature biotechnology [Category] SARS, 바이오마커, 임상, 진단, 치료기술, [키워드] COVID-19 diagnostics [DOI] 10.1038/s41587-020-0597-x [Article Type] News
Body Composition Findings by Computed Tomography in SARS-CoV-2 Patients: Increased Risk of Muscle Wasting in ObesityArticle Published on 2020-06-302022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] applied assist Body body composition caused characteristic complex Complication Computed tomography COVID-19 COVID-19 patient CT scan Diagnostic imaging diagnostics evaluate fat finding frailty greater help high risk Hospitalization ICU increase in Increased increased risk Inflammation lean lean mass liver liver attenuation Long low-grade inflammation Malnutrition management muscle Muscle wasting nutritional status obese obesity paradoxical parameter Pathways Patient profile recognize reduce risk SARS-CoV-2 subjects therapy treat wasting [DOI] 10.3390/ijms21134670 PMC 바로가기 [Article Type] Article
Genomic determinants of pathogenicity in SARS-CoV-2 and other human coronaviruses530 Published on 2020-06-302022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Analysis animal coronavirus cause coronavirus coronavirus virulence Coronaviruses COVID-19 COVID-19 pandemic determinant diagnostics element Fatality rate feature Genome genomic globe Host Human human coronavirus humans identify include less MERS-CoV Middle East molecular analysis nuclear localization signal nucleocapsid nucleocapsid protein other coronavirus Outbreaks pathogenic coronaviruses pathogenicity Pathogens public health respiratory syndrome coronavirus SARS-CoV SARS-CoV-2 Significance spike glycoprotein Spike protein target unique virus [DOI] 10.1073/pnas.2008176117 PMC 바로가기 [Article Type] 530
Multiple approaches for massively parallel sequencing of SARS-CoV-2 genomes directly from clinical samples임상 샘플에서 직접 SARS-CoV-2 게놈의 대규모 병렬 시퀀싱을 위한 여러 접근 방식Research Published on 2020-06-302022-08-13 Journal: Genome Medicine [Category] SARS, 유전자 메커니즘, [키워드] (coronavirus disease 2019 Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Amplicon amplicon method Amplicon sequencing analyses Analysis applied approach approaches best capture capture method caused Characteristics clinical sample clinical samples Complete coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cultured isolate demonstrated diagnostics Dilution Efficiency eight Emerging infectious diseases Epidemic Epidemiology Evolution examined Factor full-length SARS-CoV-2 genetic information Genome Genome sequencing genomes Genomic surveillance Guidance Hybrid capture inter- and intra-individual variations inter-individual inter-individual and intra-individual variations intra-host dynamics intra-individual variation iSNV knowledge Metatranscriptomic sequencing Multiple Multiplex PCR novel multiplex PCR amplicon offer PCR amplicon Quasispecies reported respiratory Result SARS-CoV-2 SARS-CoV-2 genome scarcity sensitivity Sequencing severe acute respiratory syndrome Coronavirus Therapeutics ultra-high-throughput metatranscriptomic variations Viral Viral load viral loads viral read Viral transmission virus Virus evolution Virus-host interaction Virus-host interactions viruses whole-genome sequencing [DOI] 10.1186/s13073-020-00751-4 PMC 바로가기 [Article Type] Research
Coronavirus Disease Pandemic (COVID-19): Challenges and a Global PerspectiveReview Published on 2020-06-282022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] acute respiratory distress acute respiratory syndrome affected amino acid residues Analysis ancestors animal models approach ARDS bat caused challenge children clinical outcomes clinical trials Comorbidity confirmed case coronavirus coronavirus disease Coronavirus-2 COVID-19 COVID-19 pandemic Cytokine storm Diagnosis diagnostics disease disease transmission Epidemiology etiological faster fatality furin-like cleavage site genomic Genomic analysis globe high-density Host Laboratory less Measures MERS-CoV Middle East pandemic pathobiology point-of-care positioned Replication researcher reservoirs S1/S2 and S2′ SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-like CoVs similarity Spread susceptibility susceptible syndrome the spike protein Therapeutics transmission of SARS-CoV-2 Vaccine Vaccines [DOI] 10.3390/pathogens9070519 PMC 바로가기 [Article Type] Review
A new threat from an old enemy: Re-emergence of coronavirus (Review)Article Published on 2020-06-272023-06-14 Journal: International journal of molecular medicine [Category] MERS, SARS, [키워드] coronavirus COVID-19 diagnostics Epidemiology MERS-CoV pathogeny SARS-CoV virulence strains [DOI] 10.3892/ijmm.2020.4555 PMC 바로가기 [Article Type] Article
Molecular and Serological Tests for COVID-19. A Comparative Review of SARS-CoV-2 Coronavirus Laboratory and Point-of-Care DiagnosticsReview Published on 2020-06-262022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] accelerate anti-viral antibody Asymptomatic blood/serum cause clinical decision Comparative coronavirus 2 COVID-19 COVID-19 diagnosis diagnostics disease facilitate genetic material healthcare identify immunoassay in vitro diagnostic tests infection control Isolation Laboratory test Laboratory testing management Microarray National pandemic point-of-care preventative measures Protein Quantitative respiratory reverse transcription PCR review RT-qPCR SARS-CoV-2 serology serology immunoassays specimens Test Treatment [DOI] 10.3390/diagnostics10060434 PMC 바로가기 [Article Type] Review
Development and Evaluation of a Duo SARS-CoV-2 RT-qPCR Assay Combining Two Assays Approved by the World Health Organization Targeting the Envelope and the RNA-Dependant RNA Polymerase (RdRp) Coding RegionsArticle Published on 2020-06-252022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] Accuracy acute respiratory syndrome Berlin caused circulation coronavirus COVID-19 demonstrated development Diagnosis diagnostic diagnostics emerging envelope false-negative Germany impair intensity Internal control molecular Molecular diagnosis mutations outbreak parental Paris performed polymorphism preparedness Prevent RdRP Real-time PCR Region respiratory response resulting RNA robust RT-qPCR RT-qPCR assay SARS-CoV-2 screening tests selected sensitivity specificity TaqMan targeting unique university virus WHO World Health Organization [DOI] 10.3390/v12060686 PMC 바로가기 [Article Type] Article
Clinical and Analytical Performance of an Automated Serological Test That Identifies S1/S2-Neutralizing IgG in COVID-19 Patients SemiquantitativelyImmunoassays Published on 2020-06-242022-10-30 Journal: Journal of Clinical Microbiology [Category] COVID-19, MERS, [키워드] acute respiratory syndrome antibody automated average chemiluminescence CLIA clinical coronavirus CoV COVID-19 COVID-19 diagnosis Cutoff Diagnosis diagnostic diagnostics disease evaluated IgG immunoassays immunoserology Laboratory LIAISON measure Neutralization assay Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody neutralizing capacity offered pandemic performance plasma positive Predictive Protein provided ranged S1/S2 Safe SARS-CoV-2 selective sensitivity Serological testing serum specificity spike Test the SARS-CoV-2 therapeutic use to define Variation [DOI] 10.1128/JCM.01224-20 PMC 바로가기 [Article Type] Immunoassays