Ready, Set, Fuse! The Coronavirus Spike Protein and Acquisition of Fusion CompetenceReview Published on 2012-04-122022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] activate angiotensin converting enzyme 2 antiviral therapies Carcinoembryonic antigen cathepsin cofactor competence coronavirus Coronavirus infection endocytosis Endosomes fusion highlight Interaction interactions membrane fusion other protease protease Proteins receptor response S protein S proteins spike Spike protein transmembrane protease transmembrane serine protease triggers TTSPs viral pathogenesis viral spike virus virus entry virus-cell membrane fusion [DOI] 10.3390/v4040557 PMC 바로가기 [Article Type] Review
Yeast Based Small Molecule Screen for Inhibitors of SARS-CoVResearch Article Published on 2011-12-022022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] activities activity Alter bypasse Cell culture cells cellular connection conserved Course demonstrated deubiquitinase Diversity expressed functional growth human coronaviruses induce induction Influenza virus inhibit inhibited inhibiting the function inhibitor inhibitory compounds investigated likelihood mammalian cells mechanism modify molecule Mortality NIH outbreak Papain-like protease phenotype PLP precursor protease Protease activity Replication reservoir Respiratory Coronavirus resulting S. cerevisiae SARS-CoV Screen severe shown small molecule suppressor toxic effect virus replication yeast [DOI] 10.1371/journal.pone.0028479 PMC 바로가기 [Article Type] Research Article
Profiling of Substrate Specificities of 3C-Like Proteases from Group 1, 2a, 2b, and 3 CoronavirusesResearch Article Published on 2011-11-022022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] 3CL pro acute respiratory syndrome Betacoronavirus cleaved coronavirus correlated CoV CoVs different finding Gln group human CoV hydrophobic residue hydrophobicity IBV Infection Infectious Bronchitis Virus inhibitor NL63 OC43 polyprotein Profiling protease Proteases protein sequences Proteolytic processing residue residues SARS-CoV secondary structure sequence similarity Specificities specificity structural property Substitution substrate variant viral replication Volume [DOI] 10.1371/journal.pone.0027228 PMC 바로가기 [Article Type] Research Article
New Tetromycin Derivatives with Anti-Trypanosomal and Protease Inhibitory Activities †Article Published on 2011-09-262022-10-30 Journal: Marine Drugs [Category] Coronavirus, [키워드] activity Analysis anti-trypanosomal antiparasitic assigned Axinella cathepsin B cathepsin L Compound cysteine protease derivative derivatives Leishmania major marine sponge New NMR spectroscopy protease protease inhibition SARS-CoV M Streptomyce Streptomyces axinellae Structure tested tetromycin Trypanosoma [DOI] 10.3390/md9101682 PMC 바로가기 [Article Type] Article
Profiling of Substrate Specificity of SARS-CoV 3CL proResearch Article Published on 2010-10-062022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] 3CL pro autocleavage charged residue cleavage Coronaviral correlated demonstrated detected different electrostatic interaction energy transfer finding fluorescent protein found Gln hydrophobic hydrophobic residue in vitro Infection inhibitors Mutagenesis polyprotein Profiling protease required residue residues SARS-CoV sequence solvent specificity Structural properties substitutions substrate variant wild-type β-sheet [DOI] 10.1371/journal.pone.0013197 PMC 바로가기 [Article Type] Research Article
Cleavage of the SARS Coronavirus Spike Glycoprotein by Airway Proteases Enhances Virus Entry into Human Bronchial Epithelial Cells In VitroResearch Article Published on 2009-11-172022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] 16HBE ACE2 ACE2 binding Activation acute respiratory syndrome against SARS-CoV airway Amino acid analysis arginine residue bronchial bronchial epithelial cell cell entry Chromatography cleavage cleaved coronavirus demonstrated dependent on different Efficacy Efficiency exhibited expand expressing expression Extracellular finding full-length glycoprotein host cell HPLC Human implication in vitro investigated lack liquid mechanism molecular basis mutant not affect performance potential therapeutic agent protease Proteases Protein R667 R797 Receptor binding regulate Respiratory system S-protein SARS-CoV SARS-CoV infection Sequencing shown spike susceptibility susceptible Treatment trimer trypsin viral entry viral envelope virus virus entry [DOI] 10.1371/journal.pone.0007870 PMC 바로가기 [Article Type] Research Article
SARS-Coronavirus Replication/Transcription Complexes Are Membrane-Protected and Need a Host Factor for Activity In VitroResearch Article Published on 2008-05-022022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] activity acute respiratory syndrome addition Author cause centrifugation characteristic complex complexes connection Critical cytoplasm cytoplasmic Degradation dependent on develop digestion dissect eight enzyme Enzymes Factor fraction functional genomic RNA Host host cell membranes host cells in vitro in vitro activity Infected infected cell life-threatening membrane membrane structure membrane structures membranes non-structural protein NSP Nsps polyproteins precursor produced protease PROTECT protein synthesis released remained replicate Replication required RNA RNA synthesis robust RTC SARS-coronavirus SARS-CoV SARS-CoV-infected cells Structure subgenomic mRNA subgenomic mRNA synthesis subunit susceptible Transcription Treatment viral genome replication Viral RNA viral RNA synthesis virus-induced membrane structure virus-induced membrane structures [DOI] 10.1371/journal.ppat.1000054 PMC 바로가기 [Article Type] Research Article
Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main ProteasesResearch Article Published on 2005-10-062022-10-28 Journal: PLoS Biology [Category] Coronavirus, [키워드] anti-CoV drug antigens Antiviral antiviral activity assays cellular cellular entry Cluster complexes Compound conserved coronavirus CoV CoVs crystal structure disease Diseases drug enzyme enzyme activity gastroenteritis Gene Expression Genetic homology model host receptor Human in viral in vitro inactivation Infection inhibitor M pro mechanism Modification Mutation NO pathogen prevalent Prevent protease recombination rate Replication representing structural protein Structure supported targeting Toxicity Vaccines virus [DOI] 10.1371/journal.pbio.0030324 PMC 바로가기 [Article Type] Research Article
Expanding the frontiers of existing antiviral drugs: Possible effects of HIV-1 protease inhibitors against SARS and avian influenzaArticle Published on 2005-05-122022-11-01 Journal: Journal of Clinical Virology [Category] Coronavirus, Fulltext, 조류인플루엔자, [키워드] acute respiratory syndrome antiretroviral Antiviral antiviral drug Clinical studies computational simulation coronavirus disease docking Effect Evidence HIV-1 protease inhibitor humans imperative in silico in vivo Influenza Influenza virus influenza viruses inhibition assay PI Possible potential benefit potential therapeutic agent protease provided public health RNA-dependent RNA polymerase Safe SARS SARS Coronavirus SARS-CoV subunit suggested therapy these compound Type-A influenza viral disease [DOI] 10.1016/j.jcv.2005.03.005 PMC 바로가기 [Article Type] Article