Comparative Anti-Infectious Bronchitis Virus (IBV) Activity of (-)-Pinene: Effect on Nucleocapsid (N) ProteinArticle Published on 2011-01-252022-10-30 Journal: Molecules [Category] Coronavirus, [키워드] (-)-pinene active site activity anti-IBV activity binding energy Cell Comparative Compound Concentration determined docking Effect found IBV indicated Infectious Bronchitis Virus ingredient inhibit molecular MTT N terminus nucleocapsid occur penetration phosphorylated Protein Result TD virus [DOI] 10.3390/molecules16021044 PMC 바로가기 [Article Type] Article
Avian coronavirus infectious bronchitis virus susceptibility to botanical oleoresins and essential oils in vitro and in vivoArticle Published on 2010-01-212022-11-01 Journal: Virus research [Category] Coronavirus, MERS, [키워드] addition Administering Botanical extracts Clinical sign Compound coronavirus CPE, cytopathic effects Dilution disease effective EID50, 50% embryo infectious dose ELISA, enzyme linked immunosorbent assay essential oils examined expected greater HMA, hexamethylene amiloride Host IBV IBV, infectious bronchitis virus in vitro in vivo Infection Infectious Bronchitis Virus investigated knowledge Laboratory lesion Massachusett MHV, mouse hepatitis virus Natural ingredients Oleoresins PBS, phosphate buffered saline protection reduced RFLP, restriction fragment length polymorphism RT-PCR, Reverse transcriptase-polymerase chain reaction SARS-CoV, Severe Acute Respiratory Syndrome virus serotype severity SPF, specific pathogen free susceptibility TCID50, 50% tissue culture infectious dose Transmission Treatment Vero E6 cell Viral RNA virucidal virus Virus challenge virus inactivation virus titer viruses was determined [DOI] 10.1016/j.virusres.2010.01.006 PMC 바로가기 [Article Type] Article
Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main ProteasesResearch Article Published on 2005-10-062022-10-28 Journal: PLoS Biology [Category] Coronavirus, [키워드] anti-CoV drug antigens Antiviral antiviral activity assays cellular cellular entry Cluster complexes Compound conserved coronavirus CoV CoVs crystal structure disease Diseases drug enzyme enzyme activity gastroenteritis Gene Expression Genetic homology model host receptor Human in viral in vitro inactivation Infection inhibitor M pro mechanism Modification Mutation NO pathogen prevalent Prevent protease recombination rate Replication representing structural protein Structure supported targeting Toxicity Vaccines virus [DOI] 10.1371/journal.pbio.0030324 PMC 바로가기 [Article Type] Research Article
In vitro susceptibility of 10 clinical isolates of SARS coronavirus to selected antiviral compoundsShort Communication Published on 2004-05-182022-11-01 Journal: Journal of Clinical Virology [Category] Coronavirus, [키워드] acute respiratory syndrome antiviral activity antiviral agent Antiviral compound Antiviral compounds assay cell line cell lines Checkerboard Chinese Combination Compound different drug Epidemics glycyrrhizin interferon interferon-alpha isolate neutralisation test performed placebo controlled trial plaque reduction assays profile Prophylaxis randomised Result ribavirin SARS Coronavirus screened selected Severe acute respiratory syndrome susceptibility synergistic synergy Toxicity Treatment [DOI] 10.1016/j.jcv.2004.03.003 PMC 바로가기 [Article Type] Short Communication
Inhibition of SARS Coronavirus Infection In Vitro with Clinically Approved Antiviral DrugsResearch Published on 2004-04-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, [키워드] acute respiratory syndrome agents Antiviral Antiviral agents antiviral drug antiviral drugs antivirals approved caused clinical testing clinically Compound coronavirus Coronavirus infection Culture cultured cell Cytopathic effect drug effective in vitro Infectious disease inhibition inhibitors interferon interferons investigated leukocyte neuraminidase inhibitors nucleoside analogs protease inhibitors SARS virus SARS-CoV SARS-CoV infection severe Severe acute respiratory syndrome Subtypes Support transcriptase treat Treatment was used [DOI] 10.3201/eid1004.030458 PMC 바로가기 [Article Type] Research