Early Phylogenetic Diversification of SARS-CoV-2: Determination of Variants and the Effect on Epidemiology, Immunology, and DiagnosticsArticle Published on 2020-05-262022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] Analysis analyzed antigenicity base substitution bases Cluster Clustering COVID-19 Deletion Determination diagnostics drugs Effect Effectiveness epidemiological Evolution genomes immune response Immunity Immunological memory immunology indication Metadata molecular Molecular epidemiology NCBI database pandemic pathogen performed Phylogenetic phylogenetically predicted presenting primer binding site Protein Region reveal SARS-CoV-2 SARS-CoV-2 lineage SARS-CoV-2 sequence selected target region variant variants Variation virulence virus virus variant detection while whole genome sequence [DOI] 10.3390/jcm9061615 PMC 바로가기 [Article Type] Article
BBMRI-ERIC’s contributions to research and knowledge exchange on COVID-19Policy Published on 2020-05-222022-10-04 Journal: European Journal of Human Genetics [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] activity Biobank biobanking clinical trials collected COVID-19 COVID-19 pandemic diagnostics European facilitate healthcare help Host information involved knowledge Medical research platform prospective cohort recommendation Research resource risk Social sciences Treatment unique utility [DOI] 10.1038/s41431-020-0634-8 PMC 바로가기 [Article Type] Policy
Development of multi-specific humanized llama antibodies blocking SARS-CoV-2/ACE2 interaction with high affinity and avidityLetter Published on 2020-05-222022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, SARS, [키워드] ACE2 receptor antibody approach bi-specific antibody binding Combination combination therapies contribute COVID-19 development diagnostics domains facilitate high affinity host cell host cell membranes humanized humanized antibody in-silico Interaction limitation llama antibody MERS monoclonal MOST multiple mechanism nanobody overcome pandemic polyclonal Protein S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus significantly synergistic therapeutic tri-specific antibody trimeric spike unique viral disease virus entry [DOI] 10.1080/22221751.2020.1768806 PMC 바로가기 [Article Type] Letter
SARS-CoV-2 detection with CRISPR diagnosticsCorrespondence Published on 2020-05-192022-10-04 Journal: Cell Discovery [Category] 진단, [키워드] Biological techniques CRISPR diagnostics Molecular biology SARS-CoV-2 detection [DOI] 10.1038/s41421-020-0174-y PMC 바로가기 [Article Type] Correspondence
Development of a reverse transcription-loop-mediated isothermal amplification as a rapid early-detection method for novel SARS-CoV-2Article Published on 2020-05-182022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, MERS, SARS, [키워드] addition can be used collected colorimetric detection contribute Coronaviruses COVID-19 COVID-19 patient cross-reactivity detect Detection limit development Diagnostic method diagnostics disease disease-causing evaluated exhibited H3N2 H5N1 H7N9 HCoV-229E HCoV-NL63 HCoV-OC43 HRV Influenza virus isothermal amplification Laboratory less MERS-CoV Molecular diagnosis MPV Novel coronavirus Nucleocapsid gene outbreak primer set Public health response qRT-PCR researcher reverse transcription reverse transcription-loop-mediated isothermal amplification RNA copy RT-LAMP SARS-CoV SARS-CoV-2 Sensitivity and specificity specimen Spread suspected patients the SARS-CoV-2 Transmission Viral RNA virus [DOI] 10.1080/22221751.2020.1756698 PMC 바로가기 [Article Type] Article
COVID-19 pandemic: an overview of epidemiology, parthenogenesis, diagnostics and potential vaccines and therapeuticsReview Published on 2020-05-132022-10-28 Journal: Therapeutic Delivery [Category] COVID-19, SARS, [키워드] Abstract against SARS-CoV antimalarial antivirals bevacizumab clinical evaluation clinical therapy coronavirus COVID-19 death diagnostics Epidemic Epidemiology evaluated Favipiravir FDA-approved drug Genetic highlight Hydroxychloroquine immunomodulator Infection Middle East pandemic Patient preventive measures recent Remdesivir repurposed therapies Respiratory Coronavirus SARS-CoV SARS-CoV-2 shown similarity syndrome Tocilizumab Vaccine Vaccine development viruses [DOI] 10.4155/tde-2020-0035 PMC 바로가기 [Article Type] Review
Assessment of the Angolan (CHERRT) Mobile Laboratory Curriculum for Disaster and Pandemic ResponseEndemic Infections Published on 2020-05-132022-10-28 Journal: Western Journal of Emergency Medicine [Category] COVID-19, SARS, [키워드] 95% confidence interval affecting Angola assessment conducted confirmed case Contagion contagious coronavirus country COVID-19 COVID-19 testing curriculum death diagnostic diagnostics disaster Disease prevalence Ebola Effectiveness Final identify individuals lab Laboratory lack Likert scale Mobile National negative sample PCR polymerase chain positive process improvement provide question rapid response reported resource respond response Result RRT Safe statistical t-test the United State was performed was used World Health Organization [DOI] 10.5811/westjem.2020.4.47385 PMC 바로가기 [Article Type] Endemic Infections
Virus detections among patients with severe acute respiratory illness, Northern VietnamResearch Article Published on 2020-05-122022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] 95% CI acute respiratory illness Adenovirus adjusted benefit clinics coronavirus death demographics demonstrated diagnostics enrolled epidemiologically Evidence Factor analysis greater hospital increased risk infections influenza A influenza A virus influenza B lack Medicine molecular morbidity nasopharyngeal sample pathogen Patient positive prevalent respiratory viral respiratory viruses School Singapore tested treatable Undetermined viral infection virus virus detection was performed were recorded [DOI] 10.1371/journal.pone.0233117 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2/COVID-19: Viral Genomics, Epidemiology, Vaccines, and Therapeutic InterventionsReview Published on 2020-05-102022-10-28 Journal: Viruses [Category] COVID-19, MERS, SARS, [키워드] acute respiratory distress Analysis approach asymptomatic infection caused coronavirus COVID-19 COVID-19 pandemic database diagnostics Drug discovery Epidemiology etiology fatality genomic Genomics help Impact Infection information Lower respiratory tract mild respiratory symptom molecular novel SARS-CoV-2 virus pandemic protein interactions provide resource SARS-CoV-2 Scientific community severe pneumonia Symptom therapeutic intervention therapeutic interventions transcriptomic transcriptomics Transmission Treatment Vaccine Vaccine development viral genomics viral pathogenicity virus [DOI] 10.3390/v12050526 PMC 바로가기 [Article Type] Review
Point-of-care testing for COVID-19 using SHERLOCK diagnosticsArticle Published on 2020-05-082022-10-06 Journal: medRxiv [Category] 진단, [키워드] approach cause Combination comparable COVID-19 COVID-19 patient Critical diagnose diagnosed diagnostics disease detection effective effort equipment handling implementation isothermal amplification lateral flow limit of detection mitigate Nasopharyngeal swab novel coronavirus SARS-CoV-2 offer outbreak Patient point-of-care positive provide public health reagent reduced replicates reported required RT-qPCR Saliva SARS-CoV-2 SARS-CoV-2 test sensitivity significantly Testing viral genome viral spread [DOI] 10.1101/2020.05.04.20091231 PMC 바로가기 [Article Type] Article