Molecular detection and genetic characterization of Mycoplasma gallisepticum , Mycoplama synoviae, and infectious bronchitis virus in poultry in MyanmarResearch Article Published on 2019-07-252022-10-28 Journal: BMC veterinary research [Category] Coronavirus, MERS, [키워드] Analysis Asian Avian Influenza Avian mycoplasmosis collected disease distribution eight Genetic Genotype IBV identifying Infectious Bronchitis Virus information isolate maintain Myanmar Mycoplasma Mycoplasma gallisepticum Mycoplasma synoviae pathogen Periodic polymerase chain protocols reported required Respiratory disease Respiratory pathogens Result Sample serotype Strains Surveillance vaccination Vaccine variant [DOI] 10.1186/s12917-019-2018-2 PMC 바로가기 [Article Type] Research Article
Parallel evolution leading to impaired biofilm formation in invasive Salmonella strains침습성 살모넬라 균주에서 손상된 생물막 형성으로 이어지는 병렬 진화Research Article Published on 2019-06-242022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 살모넬라증, [키워드] acting African Amino acid amino acids Analysis Author biofilm C-terminus caused Cellulose children clade clinician colonize comparison conserved death disease eight environmental niche environmental reservoir environmental reservoirs Evidence Evolution Fever food supply gastroenteritis gene mutation Genotype Health Host hosts humans hygiene impairment Infection intestine intestines invasive invasive disease investigated isolate isolates less Lineage lineages NTS organism parallel evolution Pathogens phenotype Phylogenetic analysis Prevent profile promoter region Public raise reduced reducing Regulatory replicate reporter researcher retained Salmonella Salmonella Enteritidis Salmonella Typhi Salmonella Typhimurium salmonellosis SNP strain Strains structural gene Structure Support survival systemic infections Transcription Transmission truncation typhoid fever water [DOI] 10.1371/journal.pgen.1008233 PMC 바로가기 [Article Type] Research Article
Genetic Diversity and Phylodynamics of Avian Coronaviruses in Egyptian Wild BirdsArticle Published on 2019-01-142022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] Analysis avian coronavirus Bird characterized circulating Clustering collected consequence coronavirus country demonstrated disease spread distal Diversity Egypt eight FIVE genetic diversity Genotype globe highlight identity isolate Lineage majority monitoring Mutation rates nine nucleotide percentage phylodynamics positive reported required strain Swab the disease variant were used wild bird [DOI] 10.3390/v11010057 PMC 바로가기 [Article Type] Article
Human genetic variation in GLS2 is associated with development of complicated Staphylococcus aureus bacteremiaGLS2의 인간 유전적 변이는 복잡한 황색 포도구균 균혈증의 발병과 관련이 있습니다Research Article Published on 2018-10-052022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activate age allele Analysis association Bacteremia Bacteria Bacterial Blood cells bloodstream Bonferroni correction candidate gene capture cause causes Cell coding variant complex Complication Control correlated CRISPR CRISPR-Cas9 cumulative cumulative effect death eight ENCODE evaluated examined exhibited Exome expression expression level Factor Frequency gene-based analysis gene-expression Genetic genetic factors genetic risk factor Genetic variant genetic variants Genetic variation Genome GLS2 Glutamine growth healthy controls Hospitalization Host Human Human genome immune response individual Infection infections Interaction key factor leukocyte leukocyte activation Logistic regression analysis Macrophage macrophage cells metabolism Microarray missense variant nitric oxide plasma concentration Protein regulate Regulatory Replication risk S . aureus sequence Sequencing Sex significantly significantly lower Staphylococcus aureus susceptible the strongest These cells Transcription variant variants Variation variations WES White blood cell White blood cells wild-type cells [DOI] 10.1371/journal.pgen.1007667 PMC 바로가기 [Article Type] Research Article
Proficiency testing for the detection of Middle East respiratory syndrome coronavirus demonstrates global capacity to detect Middle East respiratory syndrome coronavirusResearch Article Published on 2018-08-272022-11-01 Journal: Journal of medical virology [Category] Coronavirus, [키워드] complex Contamination coronavirus Coronaviruses country cross death demonstrated detect eight IMPROVE in vitro Infection Laboratory majority Middle East Middle East respiratory syndrome Coronavirus nine nucleic acid testing Program quality assessment Quality assurance reduced regions reported respiratory syndrome coronavirus RNA transcript Saudi Arabia scored sensitivity specimen specimens subtype Testing Viral load was used World Health Organization [DOI] 10.1002/jmv.25266 PMC 바로가기 [Article Type] Research Article
Experimental infection of dromedaries with Middle East respiratory syndrome-Coronavirus is accompanied by massive ciliary loss and depletion of the cell surface receptor dipeptidyl peptidase 4Article Published on 2018-06-272022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] accompanied addition analyzed Cell ciliary Coronavirus infections demonstrated Dipeptidyl peptidase 4 disease DPP4 eight epithelial cell expressed expressing expression level Health highlight histology immunofluorescence immunohistochemistry immunolabeling Infection information investigated lack lymphocyte Macrophage macrophages manifestation MERS MERS-CoV MERS-CoV infection Microscopy Middle East Monocytes nasal turbinate outcome Pathogenesis patients PBS positive cells post infection promote receiving recent Respiratory disease source of infection surface receptor syndrome T cells tissue vaccination viral cell virus virus entry [DOI] 10.1038/s41598-018-28109-2 PMC 바로가기 [Article Type] Article
Effect of ready-to-use supplementary food on mortality in severely immunocompromised HIV-infected individuals in Africa initiating antiretroviral therapy (REALITY): an open-label, parallel-group, randomised controlled trial항레트로바이러스 요법(REALITY)을 시작하는 아프리카의 심각한 면역 저하 HIV 감염 개인의 사망률에 대한 즉시 사용 가능한 보충 식품의 효과: 공개, 병렬 그룹, 무작위 대조 시험Article Published on 2018-04-102022-09-06 Journal: The Lancet. HIV [Category] Communicable Disease, [키워드] 1:1 95% CI adverse event adverse events age analysed anti-infection Antiretroviral therapy ART assigned block size BMI body-mass body-mass index both groups CD4 cell Cell changes in children clinic visit Clinic visits computer-generated database Department development died Dispensing Effect eight Eligible participants Evidence evidence of finding funding global health GRADE greater hazard ratio high risk HIV infection hospital hypothesise Immunocompromised in both group individual individuals infected individuals infections Intention intention to treat Interaction ISRCTN ISRCTN registry Kenya log-rank Medical Research Council medication micronutrients Mortality no evidence of nutritional status Older Open-label outcome parallel-group participant Participants peanut per day Policy present Primary outcome Prophylaxis raltegravir randomisation randomised controlled trial Randomly ready-to-use therapeutic food reducing Registered reported Safety secondary Secondary outcomes Serious Adverse Event Serious Adverse Events significantly stratified sub-Saharan Africa Symptom Trial Uganda vital status weight weight gain Wellcome Trust would increase Z score Zimbabwe [DOI] 10.1016/S2352-3018(18)30038-9 PMC 바로가기 [Article Type] Article
A metagenomic viral discovery approach identifies potential zoonotic and novel mammalian viruses in Neoromicia bats within South AfricaResearch Article Published on 2018-03-262022-10-28 Journal: PLoS ONE [Category] Coronavirus, Fulltext, 조류인플루엔자, [키워드] Adenoviridae Adenovirus African Amplicon sequencing Analysis anthropogenic approach bat bats Circoviridae coding collected Complete conserved Contact Conventional Coronaviridae coronavirus Coronaviruses Coverage determine eight fecal FIVE gene region generate genetic diversity Genome Herpesviridae highlighting Host hosts identify identity Illumina Miseq intestinal tissue lack library mammalian metagenomic metagenomic sequencing Middle East MiSeq nucleotide Papillomaviridae Parvoviridae PCR analysis PCR assay platform Population producing rectal Region regions Sample sequence sequenced sequencing data sequencing depth South Africa Specy Structure syndrome viral family Viral particles virus was determined were used widespread zoonotic [DOI] 10.1371/journal.pone.0194527 PMC 바로가기 [Article Type] Research Article
Coronavirus and paramyxovirus in bats from Northwest ItalyResearch Article Published on 2017-12-222022-10-28 Journal: BMC veterinary research [Category] Coronavirus, Fulltext, 조류인플루엔자, [키워드] Alpha bat Bat-borne viruses beta-CoV clade Cluster conserved coronavirus CoV CoVs database described detection rate eight emerging viruses Europe European expand Genetic Genetic characterization Host hosts Human Italian regions Italy knowledge management measure molecular MONITOR Myotis paramyxovirus Pathogens PCR PCR positive Performing Phylogenetic Pipistrellus Plecotus polymerase public health Result risk RNA Screening sequence Surveillance threat Transmission unique viral burden virus were used zoonotic zoonotic infection [DOI] 10.1186/s12917-017-1307-x PMC 바로가기 [Article Type] Research Article
Identification of two mutation sites in spike and envelope proteins mediating optimal cellular infection of porcine epidemic diarrhea virus from different pathwaysResearch Article Published on 2017-08-302022-10-28 Journal: Veterinary Research [Category] Coronavirus, [키워드] aa deletion absence activate affected Analysis Apoptosis arginine cellular Characteristics Comparative conserved E protein eight envelope protein epidemic diarrhea ER stress expression Frame functional protein Genes genomic variation glycine GRP78 homologous host cell identification IL-6 IL-8 independent induce Infection membrane fusion morphology Mutation pathway PEDV potential mechanism pro-inflammatory cytokine proliferate proliferation protease Protein Receptor binding Replication responsible S2′ cleavage screened single mutation strain supplementary material transmembrane domain trypsin Variation Vero cells virion virus virus titer whole genome sequence α-coronavirus [DOI] 10.1186/s13567-017-0449-y PMC 바로가기 [Article Type] Research Article