Defining the Syrian hamster as a highly susceptible preclinical model for SARS-CoV-2 infectionResearch Article Published on 2020-12-252022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, MERS, SARS, [키워드] adaptive age approved caused Course COVID-19 COVID-19 patients death disease Disease model FIVE hamster immune Infection infection model infectious dose interleukin 2 intranasal lung Mild moderate pandemic Particles Pneumonia receptor responsible SARS-CoV-2 SARS-COV-2 infection Severity of disease Sex Spread susceptibility susceptible Treatment Vaccine viral persistence virus [DOI] 10.1080/22221751.2020.1858177 PMC 바로가기 [Article Type] Research Article
Infectivity and pathogenicity of different hepatitis E virus genotypes/subtypes in rabbit modelResearch Article Published on 2020-12-242023-06-09 Journal: Emerging Microbes & Infections [Category] E형 간염, Fulltext, [키워드] hepatitis E virus Infectivity pathogenicity rabbit model susceptibility [DOI] 10.1080/22221751.2020.1858178 PMC 바로가기 [Article Type] Research Article
Anxiety and Suicidal Thoughts During the COVID-19 Pandemic: Cross-Country Comparative Study Among Indonesian, Taiwanese, and Thai University StudentsOriginal Paper Published on 2020-12-242022-10-30 Journal: Journal of Medical Internet Research [Category] COVID-19, MERS, SARS, [키워드] addition Anxiety association Care Comparative concerning COVID-19 COVID-19 pandemic Cross-country cross-sectional survey examined Facebook Factor groups Health highest Indonesia Infection information lowest mental health negatively affected objective pandemic Psychological question recruit resource response Result Risk perception social media platform student study population suicidal thoughts Support susceptibility Taiwan thought university university students WhatsApp [DOI] 10.2196/24487 PMC 바로가기 [Article Type] Original Paper
The role of children in the transmission of SARS-CoV2: updated rapid reviewResearch Theme 7: UNCOVER - Usher Institute Network of COVID-19 Evidence Reviews Published on 2020-12-232022-10-31 Journal: Journal of Global Health [Category] COVID-19, MERS, SARS, [키워드] Asymptomatic category children Community contribute COVID-19 COVID-19 patient Evidence FIVE France highest identify infect lowest New outbreak paediatric patients performed proportion provided pupil reported Result risk SARS-CoV-2 SARS-CoV-2 transmission School Schools secondary cases Seven South Spain Spread susceptibility Transmission transmission of SARS-CoV-2 transmission potential understanding virus [DOI] 10.7189/jogh.10.021101 PMC 바로가기 [Article Type] Research Theme 7: UNCOVER - Usher Institute Network of COVID-19 Evidence Reviews
Human Leukocyte Antigen (HLA) Class I Susceptible Alleles Against COVID-19 Increase Both Infection and Severity RateInfectious Disease Published on 2020-12-232022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute respiratory syndrome addition Affect Against allele allele frequency Antigen binding calculated class coronavirus correlation correlation coefficient country COVID-19 CTL cytotoxic T lymphocyte cytotoxic t lymphocyte (ctl) death explained had no Haplotype HLA HLA class I HLA-A hla-a/b haplotype HLA-A1 HLA-B HLA-B allele Human increase infected case Infection infection rate less leukocyte linear no correlation Rate reactivity Result SARS-CoV-2 SARS-CoV-2 peptide Severity rate susceptibility susceptible was obtained [DOI] 10.7759/cureus.12239 PMC 바로가기 [Article Type] Infectious Disease
Investigation of CD26, a potential SARS-CoV-2 receptor, as a biomarker of age and pathology잠재적인 SARS-CoV-2 수용체인 CD26을 연령 및 병리의 바이오마커로 조사Immunology & Inflammation Published on 2020-12-232022-08-31 Journal: Bioscience Reports [Category] MERS, SARS, 바이오마커, 유전자 메커니즘, [키워드] A significant reduction acute respiratory distress acute respiratory syndrome acute respiratory syndrome coronavirus age age-related dementia Analysis ARD bind binding Biomarker Blood blood clotting blood plasma blood smears cardiovascular disease CD26 Cell cells cellular cerebrospinal fluid Cluster cluster of differentiation collected Comorbidities controls Corona virus COVID-19 coronavirus Coronavirus-2 COVID-19 Covid-19 biomarker COVID-19 infection CSF Dementia diabetes Diabetes Mellitus differentiation dipeptidyl peptidase Dipeptidyl peptidase 4 dipeptidyl peptidase 4 (DPP4) DPP4 explain expressed glycoprotein help heterogeneity high risk host cell hypertension identify immune system in some individual individuals Infection Inflammatory inhibiting investigation leads membrane natural killer neutrophil pathology Platelet Platelets PROTECT receptor Regulatory reported respiratory respiratory distress risk of infection SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor serum serum sample serum samples subject subjects susceptibility Symptoms T-cell type 2 diabete Type 2 diabetes mellitus variety Viral viral entry viral infection virus [DOI] 10.1042/BSR20203092 PMC 바로가기 [Article Type] Immunology & Inflammation
Risk perception regarding the COVID-19 outbreak among the general population: a comparative Middle East surveyResearch Published on 2020-12-222022-10-29 Journal: Middle East Current Psychiatry [Category] COVID-19, [키워드] adopted Anxiety categories contributing to coronavirus coronavirus disease COVID-19 COVID-19 outbreak COVID-19 pandemic cross-sectional design Data collection disease driving Effectiveness Efficacy General population Health Health Education IMPROVE Incubation period information Intention Jordan key factor mean score measure Middle East MOST National Novel coronavirus outbreak participant Participants populations positive correlation precautions Prevent preventive measure preventive measures promote questionnaire receive receiving recruited reducing reported Result risk Risk perception Saudi Arabia Self-efficacy Seriousness perception significantly higher significantly lower Sociodemographic susceptibility the mean Transmission Treatment was performed was used with COVID-19 [DOI] 10.1186/s43045-020-00080-7 PMC 바로가기 [Article Type] Research
Public Database-Driven Insights Into Aging Stress-Associated Defective Gut Barrier With Low SARS-CoV-2 ReceptorsMedicine Published on 2020-12-222022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] abdominal pain acute respiratory syndrome addition aging barrier Biomarker Biomarkers caused Cell clearance contributing to coronavirus COVID-19 COVID-19 severity Defense diarrhea downregulation expression expression of SARS-CoV-2 fecal Gastrointestinal symptom global pandemic Gut Gut barrier gut barrier integrity include increasing age insight integrated stress responses metabolic stress novel coronavirus disease Public pulmonary system receptor response responses SARS-CoV-2 SARS-CoV-2 receptor Stress susceptibility transcriptomic viral entry virus vomiting [DOI] 10.3389/fmed.2020.606991 PMC 바로가기 [Article Type] Medicine
Host Genetics at the Intersection of Autoimmunity and COVID-19: A Potential Key for Heterogeneous COVID-19 SeverityImmunology Published on 2020-12-222022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] affecting association Autoimmune Autoimmune disease Autoimmunity Complication COVID-19 COVID-19 severity Critical cytokine Deleterious disease dysregulated immune response effective effective strategy Factor Factors General population Genes Genetic genetic susceptibility genetics heterogeneity heterogeneous Host host genetics immune response immune system individual Intersection Mortality outcome pathophysiology Perspective polymorphism Potential question risk SARS-CoV-2 SARS-COV-2 infection Severe case severity severity of COVID-19 significantly susceptibility the disease variable virus with COVID-19 [DOI] 10.3389/fimmu.2020.586111 PMC 바로가기 [Article Type] Immunology
A modular framework for multiscale, multicellular, spatiotemporal modeling of acute primary viral infection and immune response in epithelial tissues and its application to drug therapy timing and effectivenessResearch Article Published on 2020-12-212022-10-28 Journal: PLoS Computational Biology [Category] COVID-19, MERS, SARS, [키워드] acute viral infection Administered antiviral drug Cell Cellular immune response cellular mechanism clearance clinical effectiveness Combination component COVID-19 decrease disease Disease progression dosage drug Effect effective Effectiveness epithelial epithelial cell exhibit faster Hepatitis High dose immune immune response immune-cell Infection infection mechanism Interaction interfere less low dose mechanisms multicellular multiple groups outcome outcomes platform Potential treatment primary viral infection progression promote prophylactically recruitment reduce reduced Remdesivir Replication rate Repository Side effect Simulation spatiotemporal Support susceptibility Therapies therapy tissue tissue damage tissues Treatment viral infection Viral RNA virus virus replication viruses widespread [DOI] 10.1371/journal.pcbi.1008451 PMC 바로가기 [Article Type] Research Article