SARS-CoV-2 and Multiple Sclerosis: Potential for Disease ExacerbationReview Published on 2022-04-222023-07-09 Journal: Frontiers in Immunology [Category] COVID19(2023년), [키워드] Adaptive immunity blood-brain barrier COVID-19 Cytokine storm experimental autoimmune encephalomyelitis multiple sclerosis Neuroinflammation SARS-CoV-2 [DOI] 10.3389/fimmu.2022.871276 PMC 바로가기 [Article Type] Review
Binding and neutralizing antibody responses to SARS-CoV-2 in very young children exceed those in adults아주 어린 아이들의 SARS-CoV-2에 대한 결합 및 중화 항체 반응은 성인의 반응을 능가합니다.Article Published on 2022-04-222022-09-12 Journal: JCI Insight [Category] Coronavirus, COVID19(2023년), SARS, 진단, [키워드] Adaptive immunity Adults age antibody children Community COVID-19 COVID-19 vaccine disease Enrollment had more highest immune response Infection infections Infectious disease information neutralizing antibody Neutralizing antibody response Receptor binding resulting robust antibody response SARS-CoV-2 SARS-CoV-2-neutralizing antibody seropositive seropositive participant serum specimen Support [DOI] 10.1172/jci.insight.157963 PMC 바로가기 [Article Type] Article
Cross-reactive antibodies elicited to conserved epitopes on SARS-CoV-2 spike protein after infection and vaccinationArticle Published on 2022-04-202023-07-01 Journal: Scientific Reports [Category] COVID19(2023년), SARS, [키워드] Adaptive immunity antibodies Humoral immunity immunology Infectious diseases Medical research Translational research viral infection [DOI] 10.1038/s41598-022-10230-y PMC 바로가기 [Article Type] Article
Identification of B-Cell Epitopes for Eliciting Neutralizing Antibodies against the SARS-CoV-2 Spike Protein through Bioinformatics and Monoclonal Antibody Targeting생물정보학 및 단일클론 항체 표적화를 통한 SARS-CoV-2 스파이크 단백질에 대한 중화 항체 유도를 위한 B-세포 에피토프 식별Review Published on 2022-04-142022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, 진단, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adaptive Adaptive immunity Analysis antibody approach Astra Zeneca B cell B cells B-cell B-cell epitope B-cell epitopes caused cells complex coronavirus COVID-19 COVID-19 vaccine Critical effective Eliciting epitope Epitopes global public health Health crisis Hospitalization identification Immunity Impact in silico in vivo less linear B-cell epitope mapping membrane Moderna monoclonal antibodies monoclonal antibody multi-epitope peptide vaccine Neutralizing Neutralizing antibodies neutralizing antibody new SARS-CoV-2 nucleocapsid protein offer peptide Pfizer-BioNTech potent produced Protective provide reducing respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike Spike protein targeting the SARS-CoV-2 three-dimensional structure transmission of SARS-CoV-2 Vaccine Vaccines variants virus viruses Wuhan strain [DOI] 10.3390/ijms23084341 PMC 바로가기 [Article Type] Review
In-depth analysis of SARS-CoV-2-specific T cells reveals diverse differentiation hierarchies in vaccinated individualsSARS-CoV-2-특이적 T 세포에 대한 심층 분석은 백신 접종을 받은 개인의 다양한 분화 계층을 보여줍니다Article Published on 2022-04-082022-09-11 Journal: JCI Insight [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Adaptive immune response Adaptive immunity Analysis approach breadth Breakthrough infection breakthrough infections CD4+ T cell CD4+ T cells clinical trial clinical trials COVID-19 COVID-19 pandemic cytokine profile determinant effective Efficacy feature fraction Fractions identify IL-2 immune immunology indicate individual induce investigated Last Longevity magnitude majority mutant produced reactive recall Region responders reveal S-protein SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 vaccines SARS-CoV-2-specific T cell SARS-CoV-2-specific T cells T cell T cell response T cells TNF-α vaccinated individual vaccinated individuals vaccination Vaccine variants of concern [DOI] 10.1172/jci.insight.156559 PMC 바로가기 [Article Type] Article
Durability of ChAdOx1 nCoV-19 vaccination in people living with HIVClinical Trial Published on 2022-04-082022-10-04 Journal: JCI Insight [Category] COVID19(2023년), SARS, 변종, 임상, 치료기술, [키워드] ACE-2 Adaptive immunity AIDS/HIV Antiretroviral therapy AZD1222 baseline Beta coronaviruses CD4 Cell-mediated immunity Cellular immune response ChAdOx1 nCoV-19 Cohort correlated COVID-19 cross-reactive detectable dose Duration Evidence greater HIV HIV-uninfected humoral IFN-γ ELISPOT IgG ELISA immune response Immunity individual majority male participant marker Meso Scale Discovery neutralization no significant difference prevaccination regimen response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike serology Support T cell T cell proliferation T cell response T cells Trial undetectable vaccinate vaccination variants of concern viral loads with HIV [DOI] 10.1172/jci.insight.157031 PMC 바로가기 [Article Type] Clinical Trial
Mechanisms and clinical evidence to support melatonin’s use in severe COVID-19 patients to lower mortalityReview article Published on 2022-04-012022-10-05 Journal: Life sciences [Category] COVID19(2023년), SARS, 변종, 신약개발, 임상, [키워드] activity adaptive Adaptive immunity added antibody formation approved Cell clinical evidence clinical trial country COVID-19 downregulate driven by Emergency use ENhance FDA fraction help high mortality Host Host immune response immune reaction include Inflammation inhibit innate immune response Innate immunity intubation less limit lower mortality main protease medication Medicine melatonin Mortality Nirmatrelvir pandemic promote reduce reducing mortality Replication Ritonavir safety margin SARS-CoV-2 SARS-COV-2 infection seasonal flu severe COVID-19 severe COVID-19 patient severe COVID-19 patients severity significantly Support suppress the cytokine storm the SARS-CoV-2 therapy tracheal treat Treatment Viral virulence virus virus infection [DOI] 10.1016/j.lfs.2022.120368 [Article Type] Review article
Streptococcus pneumoniae colonization associates with impaired adaptive immune responses against SARS-CoV-2폐렴구균 군집화는 SARS-CoV-2에 대한 손상된 적응 면역 반응과 관련이 있다.Article Published on 2022-04-012023-07-01 Journal: The Journal of Clinical Investigation [Category] COVID19(2023년), SARS, 폐렴구균 감염증, [키워드] Adaptive immunity Bacterial infections immunology T cells Virology [DOI] 10.1172/JCI157124 PMC 바로가기
Neutrophil to Lymphocyte Ratio: An Emerging Marker of the Relationships between the Immune System and Diseases호중구 대 림프구 비율: 면역 체계와 질병 간의 관계에 대한 새로운 지표Review Published on 2022-03-262022-09-11 Journal: International Journal of Molecular Sciences [Category] MERS, 바이오마커, [키워드] adaptive Adaptive immunity Biomarker Cancer concerning coronavirus coronavirus disease coronavirus disease-2019 coronavirus disease-2019 (COVID-19) COVID-19 COVID-19 pneumonia cut-off value disease FLAG General population homeostasis immune system Immunity inflammatory status intensive care intensive care unit intensive care unit (ICU) lymphocyte marker molecular basis Mortality neutrophil Neutrophil-to-lymphocyte ratio neutrophil-to-lymphocyte ratio (NLR) NLR over pathophysiology patients with COVID-19 Pneumonia Prognosis Prognostic value relationship Research Sepsis subset System unique [DOI] 10.3390/ijms23073636 PMC 바로가기 [Article Type] Review
SARS-CoV-2 infection and vaccination trigger long-lived B and CD4+ T lymphocytes with implications for booster strategiesSARS-CoV-2 감염 및 백신 접종은 부스터 전략에 영향을 미치는 수명이 긴 B 및 CD4+ T 림프구를 유발합니다Article Published on 2022-03-152022-09-11 Journal: The Journal of Clinical Investigation [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] Adaptive immunity anti-spike immunity antibody antibody levels booster booster dose booster injection breakthrough infections causative agent CD4+ T cell CD4+ T cells CD4+ T lymphocyte Cellular immune response cellular immunity clinical clinical medicine Cohort CoV COVID-19 COVID-19 infection decay Department detectable Florence funds humoral humoral and cellular immunity Humoral immunity immune response Immunological memory implication individual individuals infected individuals Infection injection Italian Longitudinal evaluation Medicine memory B memory cell Memory cells Ministry of Health mRNA vaccination naïve individuals natural infection neutralization capacity occur performed persistence PROTECT reduced Reinfection restored SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variants SARS-CoV-2-infected individuals severe disease significantly Spike protein supported T cells Tuscany university vaccinated individual vaccinated individuals vaccination [DOI] 10.1172/JCI157990 PMC 바로가기 [Article Type] Article