University population-based prospective cohort study of SARS-CoV-2 infection and immunity (SARSSURV-ULiège): a study protocolSARS-CoV-2 감염 및 면역에 대한 대학 인구 기반 전향적 코호트 연구(SARSSURV-ULiège): 연구 프로토콜Article Published on 2022-01-252022-09-11 Journal: BMJ Open [Category] SARS, 진단, 치료기술, [키워드] activity All participant All participants Antibody Response Antibody responses Antibody testing approval blood sample Blood samples cohort study collected Complete COVID-19 COVID-19 pandemic detect determine Epidemiology Ethics ethics committee Evidence flexible higher education immune response Immunity immunology incidence Infection lack magnitude management medical histories MONITOR Neutralising Antibodies neutralising antibody participant Phase 1 Phase 2 population-based cohort positive Potential Prevalence profiles prospective cohort study protocol amendment public health questionnaire Rapid test rapid test result reference number Registered required Research Research Ethics Research Ethics Committee respond risk Risk assessment Risk management RT-qPCR Safe Saliva SARS-CoV-2 SARS-CoV-2 antibody testing SARS-COV-2 infection serological serological test Seroprevalence Stage student study period Study protocol submitted university university hospital vaccination Vaccine hesitancy Weekly [DOI] 10.1136/bmjopen-2021-055721 PMC 바로가기 [Article Type] Article
Measurement of SARS-CoV-2 Antibody Titers Improves the Prediction Accuracy of COVID-19 Maximum Severity by Machine Learning in Non-Vaccinated PatientsSARS-CoV-2 항체 역가의 측정은 백신 접종을 하지 않은 환자의 기계 학습을 통해 COVID-19 최대 심각도의 예측 정확도를 향상시킵니다Immunology Published on 2022-01-212022-09-11 Journal: Frontiers in Immunology [Category] 진단, 치료법, [키워드] Admission Analysis antibody Antibody Response Antibody responses Antibody testing association best breakthrough infections contribute COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity domain early phase four group four groups help identify IgA IgG IgM intensive care intensive care unit machine learning maximum measurement mechanical ventilatory support nucleocapsid protein Numerous oxygen oxygen supplementation physician prediction Receptor-binding domain required SARS-CoV-2 severity severity of COVID-19 Spike protein suggested symptom onset the antibody response the disease the patient the timing titer titers ventilatory ventilatory support [DOI] 10.3389/fimmu.2022.811952 PMC 바로가기 [Article Type] Immunology
Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infectionSARS-COV-2 감염 후 몇 달 후 말초 면역계의 장기 섭동Research Article Published on 2022-01-142022-09-01 Journal: BMC Medicine [Category] SARS, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adaptive Analysis anti-RBD Anti-RBD IgG Antibody responses Blood cellular controls convalescent convalescent individual convalescent individuals Convalescent patients coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID COVID-19 Critical CXCR3 deep disease severity Effects explain follicular Gene Expression healthy healthy controls IgG responses immune population immune response immune responses immune system Immunity Immunophenotyping in some increasingly individuals Infection Long COVID Mild moderate molecular Monocytes Neutrophils NK cells pandemic PASC Patient persistence Perturbation plethora Post COVID-19 condition Post-acute sequelae of COVID-19 (PASC) Post-infection referred to regulatory T cells reported Research respiratory respiratory virus response responsible Result RNA sequencing RNA-Seq SARS-CoV-2 SARS-COV-2 infection serological severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significant difference significant differences supplementary material Symptom syndrome T cell T cells T helper transcriptional transcriptional level Transcriptome uninfected [DOI] 10.1186/s12916-021-02228-6 PMC 바로가기 [Article Type] Research Article
Impaired neutralisation of SARS-CoV-2 delta variant in vaccinated patients with B cell chronic lymphocytic leukaemiaB 세포 만성 림프구성 백혈병 백신 접종 환자에서 SARS-CoV-2 델타 변이체 중화 장애Research Published on 2022-01-092022-09-10 Journal: Journal of Hematology & Oncology [Category] 변종, 진단, [키워드] Adenovirus adenovirus-based antibody Antibody Response Antibody responses B cell BTKi therapy CD20 Chronic lymphocytic leukaemia CLL CLL patient CLL patients control group controls COVID COVID-19 vaccination delta variant dominant dual failure functional Gender groups healthy controls healthy donor healthy donors immune protection Immune suppression Immunotherapy Impaired impaired antibody response impaired antibody responses indicate Leukaemia magnitude mRNA neutralisation Patient patient cohort post treatment Post-vaccine Predictive prophylactic antibiotics reduced respond responders responses Result risk SARS-CoV-2 SARS-CoV-2 delta SARS-COV-2 infection sera Seroconversion serum spike-specific antibody response stability supplementary material the SARS-CoV-2 titre titres Treatment vaccination Vaccine vaccine platform variant [DOI] 10.1186/s13045-021-01219-7 PMC 바로가기 [Article Type] Research
Disease characteristics and serological responses in patients with differing severity of COVID-19 infection: A longitudinal cohort study in Dhaka, BangladeshCOVID-19 감염의 중증도가 다른 환자의 질병 특성 및 혈청 반응: 방글라데시 다카의 종단 코호트 연구Research Article Published on 2022-01-042022-09-12 Journal: PLoS Neglected Tropical Diseases [Category] 진단, [키워드] addition age age and sex analyzed antibody Antibody Response antibody response against Antibody responses Asymptomatic asymptomatic infection asymptomatic infections biochemical caused Characteristics clinician co-morbid condition co-morbid conditions Community conducted Control COVID-19 COVID-19 disease COVID-19 illness COVID-19 infection CRP CRP level CRP levels D-dimer disease disease severity Disease spectrum elevated enrolled Enrollment evaluate exclusion criteria ferritin ferritin level ferritin levels Follow-up visit follow-up visits Gender geographical region healthy healthy controls help hematological parameter hematological parameters hospital IgG antibodies IgG antibody IgG levels IgM and IgG immunological parameter immunological parameters infected individual Infection levels of antibody longitudinal cohort study longitudinal study lymphocyte lymphocyte counts male many cases Mild Mild disease moderate neutrophil neutrophil count NLR normal range Older age onset of symptom outcome outcomes participant Patient patients patients with COVID-19 predict progression RBD Receptor binding domain responsible risk factor Risk factors SARS-CoV-2 serological response seropositive Severe case severe cases severe COVID-19 disease severe COVID-19 illness severe disease severe disease manifestation severe patients severity of COVID-19 significantly higher Spike protein spike protein of SARS-CoV-2 the disease the spike protein Viral load [DOI] 10.1371/journal.pntd.0010102 PMC 바로가기 [Article Type] Research Article
Humoral and Cellular Immune Responses to SARS-CoV-2 Infection and Vaccination in Autoimmune Disease Patients With B Cell DepletionB 세포 고갈이 있는 자가 면역 질환 환자의 SARS-CoV-2 감염 및 예방 접종에 대한 체액 및 세포 면역 반응Article Published on 2022-01-012022-09-11 Journal: Arthritis & rheumatology (Hoboken, N.J.) [Category] SARS, 치료법, [키워드] antibodies Antibody Response Antibody responses Autoimmune disease autoimmune disease patient Autoimmune diseases B cell B cells block Cellular immune response Control controls Critical Depletion enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay enzyme-linked immunospot assay expected healthy control healthy controls humoral Humoral and cellular immune responses humoral immune response immune responses Infection interferon interferon-γ nucleocapsid nucleocapsid protein Nucleocapsid proteins Patient protective immunity response SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 vaccination T cell T cell response T cell responses tested the patient the SARS-CoV-2 therapeutic These data vaccination were assessed [DOI] 10.1002/art.41914 PMC 바로가기 [Article Type] Article
Neutralization of SARS-CoV-2 requires antibodies against conformational receptor-binding domain epitopesSARS-CoV-2의 중화에는 구조적 수용체 결합 도메인 에피토프에 대한 항체가 필요합니다Article Published on 2022-01-012022-09-11 Journal: Allergy [Category] SARS, 변종, 진단, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibody antibody repertoire Antibody Response Antibody responses clinically conformational conformational epitopes coronavirus correlated COVID-19 Critical determinant determinants domain effective vaccine Effective vaccines epitope Epitopes exposure to humoral immune response IgG IgG antibodies IgG antibody Immunity immunization Immunoglobulin Immunoglobulin G increasingly induce likelihood Mild natural infection Neutralizing antibodies Patient peptide peptide epitope peptide epitopes peptides polyclonal polyclonal antibody Prevent Protective protective immunity RBD RBD binding RBD-specific IgG receptor Receptor-binding domain required respiratory SARS-CoV-2 SARS-CoV-2 proteins SARS-CoV-2-neutralizing antibodies SARS-CoV-2-neutralizing antibody sera severe acute respiratory syndrome Coronavirus severe COVID-19 Spike protein sterilizing immunity suppression the receptor-binding domain the SARS-CoV-2 vaccination Vaccine Vaccines variant virus Virus neutralization virus variants virus-neutralizing [DOI] 10.1111/all.15066 PMC 바로가기 [Article Type] Article
A scalable and highly immunogenic virus-like particle-based vaccine against SARS-CoV-2SARS-CoV-2에 대한 확장 가능하고 면역원성이 높은 바이러스 유사 입자 기반 백신Article Published on 2022-01-012022-09-11 Journal: Allergy [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] added addition antibody Antibody Response Antibody responses Bacterial booster booster injections candidate vaccine caused centrifugation classical convalescent COVID-19 cross-reactive dose effective hand human sera hygiene immunogenic immunologically in some induce Injections long term Masks mice mutant Neutralizing Pandemics purification RBD RBM receptor-binding motif RNA SARS-CoV-2 stability the SARS-CoV-2 the vaccine Vaccine vaccine candidate Vaccines variants variants of concern virus virus-like particles wearing masks while yield [DOI] 10.1111/all.15080 PMC 바로가기 [Article Type] Article
Defining Antibody Seroprevalence and Duration of Humoral Responses to SARS-CoV-2 Infection and/or Vaccination in a Greek Community그리스 커뮤니티에서 SARS-CoV-2 감염 및/또는 백신 접종에 대한 항체 혈청형 및 체액 반응 기간 정의Article Published on 2021-12-312022-09-12 Journal: International Journal of Environmental Research an [Category] SARS, 진단, [키워드] Abbott antibodies antibody Antibody Response Antibody responses Antibody testing Antibody titer Antibody titers Architect Community COVID-19 Duration evaluate FIVE Greece Hospitalization Hospitalized immune response Mild disease nine pandemic participant participated positive response retained SARS-CoV-2 SARS-CoV-2 IgG SARS-COV-2 infection semi-closed community Seroprevalence severe disease significantly higher subject subjects tested USA vaccination Vaccination Status virus was used with mild disease [DOI] 10.3390/ijerph19010407 PMC 바로가기 [Article Type] Article
Persistent SARS-CoV-2 infection in patients with secondary antibody deficiency: successful clearance following combination casirivimab and imdevimab (REGN-COV2) monoclonal antibody therapy2 차 항체 결핍 환자의 지속적인 SARS-COV-2 감염 : Casirivimab 및 Imdevimab (Regn-Cov2) 모노클로 날 항체 요법에 따른 성공적인 통관Case Reports Published on 2021-12-302022-09-01 Journal: Annals of Clinical Microbiology and Antimicrobials [Category] SARS, 변종, 진단, 치료기술, [키워드] accompanied administration antibody Antibody deficiency Antibody Response Antibody responses antiviral therapy B cell B cell depleting therapy benefit Case report case reports Casirivimab Chronic COVID-19 Chronic lymphocytic leukaemia clearance Clinical improvement clinical recovery clinical response clinical study Clinical use Combination convalescent plasma deficiency delivery depleting ecological ecological niche Effectiveness evade Evidence Evolution failure fatigue female follicular Follicular lymphoma Formal highlight hospitalised Ibrutinib Imdevimab immune evasion Immunotherapy increased risk individuals Infection Inflammation lack lymphoma malaise male monoclonal antibody monoclonal antibody combination nasopharyngeal swabs neutralisation omicron outcome Passive immunisation Patient patients persistent persistent infection Primary and secondary immunodeficiency raised REGN-CoV2 Remdesivir Ronapreve (REGN-COV2) SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants secondary antibody secure Sequence analysis spike variant suffered sustained therapeutic therapy treated Treatment variants variants of concern Viral viral clearance viral evolution virological clearance with COVID-19 withdrawn [DOI] 10.1186/s12941-021-00491-2 PMC 바로가기 [Article Type] Case Reports