The role of direct oral anticoagulants in the era of COVID-19: are antiviral therapy and pharmacogenetics limiting factors?코로나19 시대 직접 경구용 항응고제의 역할: 항바이러스제와 약물유전학이 제약 요인인가?Article Published on 2022-06-222022-09-11 Journal: Croatian Medical Journal [Category] 유전자 메커니즘, 치료제, [키워드] Anticoagulant Anticoagulant treatment Anticoagulants anticoagulation Antiviral agents antiviral therapy cause Coagulation system COVID-19 COVID-19 patient COVID-19 patients diagnosis of COVID-19 DOAC DOACs drug heparin Hospital admission hospitalized patient limit morbidity morbidity and mortality oral anticoagulant Outpatient outpatients Pathogenesis Patient patients with COVID-19 pharmacokinetic required therapy Thromboinflammation Treatment [DOI] 10.3325/cmj.2022.63.287 PMC 바로가기 [Article Type] Article
Remdesivir and GS-441524 Retain Antiviral Activity against Delta, Omicron, and Other Emergent SARS-CoV-2 Variants렘데시비르와 GS-441524는 델타, 오미크론 및 기타 신종 SARS-CoV-2 변이체에 대해 항바이러스 활성을 유지한다Article Published on 2022-06-212022-09-11 Journal: Antimicrobial Agents and Chemotherapy [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] 50% effective concentration activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral antiviral activity Antiviral agents Antiviral treatment change circulating Combination conserved coronavirus COVID-19 Delta disease severity Effectiveness ELISA enzyme-linked immunosorbent enzyme-linked immunosorbent assay Evidence evidence of exhibited fold Genetic variation GS-441524 highlight isolate Neutralizing antibodies Nsp12 nucleoside omicron Omicron variants Other P323L pandemic parent nucleoside potency predominant prevalent RdRP RDV reduction remained Remdesivir retained RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sequence sequences severe acute respiratory syndrome Coronavirus Spread Substitution Support susceptible sustained tested the SARS-CoV-2 Treatment Vaccine variant variants Variation Veklury Viral transmission virus viruses WA1 [DOI] 10.1128/aac.00222-22 PMC 바로가기 [Article Type] Article
Broadly Applicable, Virus-Free Dual Reporter Assay to Identify Compounds Interfering with Membrane Fusion: Performance for HSV-1 and SARS-CoV-2막 융합을 방해하는 화합물을 식별하기 위해 광범위하게 적용 가능한 바이러스 없는 이중 보고자 분석: HSV-1 및 SARS-CoV-2에 대한 성능Article Published on 2022-06-212022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] alkaline alkaline phosphatase antiviral agent Antiviral agents cell-cell fusion cell–cell fusion Compound doxycycline dual reporter assay Efficacy enzyme expressed expression fluorescent fusion inhibition HSV-1 identify inhibitors Internal control marker membrane fusion nanoluciferase nuclear Pathogens performance phosphatase quantification Replication reported reporter reporter fusion reporter gene SARS-CoV-2 secreted secreted alkaline phosphatase secreted nanoluciferase. Sensitivity and specificity Tetracycline transient transfection Vero Cell Vero cells viral pathogens was tested [DOI] 10.3390/v14071354 PMC 바로가기 [Article Type] Article
Death and invasive mechanical ventilation risk in hospitalized COVID-19 patients treated with anti-SARS-CoV-2 monoclonal antibodies and/or antiviral agents: A systematic review and network meta-analysis protocol항SARS-CoV-2 단클론항체 및/또는 항바이러스제로 치료받은 입원한 COVID-19 환자의 사망 및 침습적 기계 환기 위험: 체계적인 검토 및 네트워크 메타 분석 프로토콜Article Published on 2022-06-172022-09-11 Journal: PLoS ONE [Category] MERS, meta-analysis, 변종, 진단, 치료제, [키워드] (risk ratio 95% confidence interval acceptance Analysis anti-SARS-CoV-2 Antiviral Antiviral agents approach assessment assumption best claimed Comorbidities confidence COVID-19 pandemic COVID-19 patient Critically ill cumulative death development diagnosed effect size Evidence high risk hospitalized COVID-19 patient hospitalized patient hospitalized patients Immunocompromised indicate intensive care intensive care unit Intervention Invasive mechanical ventilation Local Meta-analysis monoclonal antibody Mortality network Network meta-analysis NMA nucleic acid nucleic acid amplification nucleic acid amplification test occur occurred outcome Patient plan PROSPERO protocol Randomized controlled trial Randomized controlled trials randomized trial randomized trials Registration reported risk risk of bia risk of infection risk ratio RoB 2 sensitivity analysis Stata Statistical Software statistical statistical significance Steroids systematic review treated Trial variants variants of concern [DOI] 10.1371/journal.pone.0270196 PMC 바로가기 [Article Type] Article
Molecular Virology of SARS-CoV-2 and Related CoronavirusesSARS-CoV-2 및 관련 코로나바이러스의 분자 바이러스학Review Published on 2022-06-152022-09-11 Journal: Microbiology and molecular biology reviews : MMBR [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료제, [키워드] accelerated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered antiviral agent Antiviral agents caused Compound coronavirus coronavirus disease Coronavirus disease 2019 Coronaviruses COVID-19 COVID-19 pandemic COVID-19 vaccine CRISPR drug effective Factor Host host cell host cell factor host cell factors involved molecular mechanism molecular mechanisms pathway Pathways public health Replication Research SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus target targets Virology [DOI] 10.1128/mmbr.00026-21 PMC 바로가기 [Article Type] Review
Long-term time trends in reactivated herpes simplex infections and treatment in Swedenarticle Published on 2022-06-152024-09-02 Journal: BMC Infectious Diseases [Category] 대상포진, [키워드] Antiviral agents Apolipoprotein E4 cohort study Epidemiology herpes simplex Seroprevalence Ultraviolet radiation [DOI] 10.1186/s12879-022-07525-w PMC 바로가기 [Article Type] article
Photodynamic Inactivation of SARS-CoV-2 Infectivity and Antiviral Treatment Effects In VitroSARS-CoV-2 감염의 광역학적 비활성화 및 시험관 내 항바이러스 치료 효과Article Published on 2022-06-142022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 antibody Antiviral Antiviral agents approach Cell cell cultures cell viability Concentration coronavirus Coronavirus-2 COVID-19 Critical Culture current death detectable Effect heat-inactivated in vivo inactivation Infection infectiousness Infectivity log measure Microscopy mitochondrial Mutation near-infrared light pandemic Pathogens PDI photodynamic inactivation photodynamic therapy photosensitizer Potential treatment qPCR reduce reduced reduction required SARS SARS-CoV-2 SARS-CoV-2 isolate severe acute respiratory syndrome Coronavirus severe disease significantly THPTS Toxicity Treatment uninfected Vaccines variety Vero Cell viability viral cytopathic effect viral infection viral infections Viral load Viral RNA virion virus virus load virus suspension viruses were assessed [DOI] 10.3390/v14061301 PMC 바로가기 [Article Type] Article
Promising Therapeutic Approach for SARS-CoV-2 Infections by Using a Rutin-Based Combination Therapy루틴 기반 조합 요법을 사용하여 SARS-CoV-2 감염에 대한 유망한 치료 접근 방식Article Published on 2022-06-032022-09-11 Journal: ChemMedChem [Category] COVID19(2023년), SARS, 치료제, [키워드] Acetylsalicylic acid addition Administered antioxidants Antiviral Antiviral agents Bacterial calcium combating combination therapy components compounds described early stage early stages flavonoids host cell indication Infection inhibit Magnesium molecular molecular recognition natural natural products noncovalent interactions offer prophylactically provide rutin Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections severe disease progression targets Therapeutic approach therapy viruses Vitamin C Vitamin D vitamins [DOI] 10.1002/cmdc.202200157 PMC 바로가기 [Article Type] Article
Construction and characterization of two SARS-CoV-2 minigenome replicon systems2개의 SARS-CoV-2 미니게놈 복제 시스템의 구성 및 특성화Article Published on 2022-06-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Antiviral Antiviral agents antiviral responses Antiviral treatment biosafety biosafety level cell line cell lines cellular cellular effect characterization complementary Complementary DNA construction coronavirus COVID-19 pandemic demonstrated disease disease control DNA early phase exhibited facilitate generate global public health Host immune immune responses Impact in vitro transcription inhibitors initial Innate immunity level 2 Messenger RNA mRNA mRNA transfection mRNA/splicing nLuc phenotype portion promise Replication reporter Research SARS Coronavirus SARS-CoV-2 SARS-CoV-2 replication severe acute respiratory syndrome Coronavirus Support Transcription transfection transient transfection variety Virology virus virus classification [DOI] 10.1002/jmv.27650 PMC 바로가기 [Article Type] Article
[Herpes zoster-prevention, diagnosis, and treatment]대상포진-예방, 진단 및 치료Review Published on 2022-06-012023-05-31 Journal: Hautarzt [Category] 대상포진, 두창, 수두, 홍역, [키워드] Analgesia Antiviral agents herpes zoster vaccine Postherpetic neuralgia shingles [DOI] 10.1007/s00105-022-04992-9 [Article Type] Review