Inference of Candidate Germline Mutator Loci in Humans from Genome-Wide Haplotype Data게놈 전체 일배체형 데이터에서 인간의 후보 생식계열 돌연변이 유전자좌의 추론Research Article Published on 2017-01-172022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 1000 Genome 1000 Genomes 1000 Genomes Project affected allele alleles base bases BRSK2 candidate Cell characterized cohorts de novo mutation de novo mutations DNA damage DNA repair elevated error expressed genetic loci Genetic variation Genome genome sequence genomic region germline Haplotype haplotypes Human human diseases Human genomes human population human populations identify incorporation increase individual Inference involved lead loci locus Mutation mutation rate Netherland occur offspring parent parents Phase 3 proportion remained replicated reported resulting searched species spontaneous mutations Support Testis thought upstream Variation [DOI] 10.1371/journal.pgen.1006549 PMC 바로가기 [Article Type] Research Article
Distinct and Atypical Intrinsic and Extrinsic Cell Death Pathways between Photoreceptor Cell Types upon Specific Ablation of Ranbp2 in Cone Photoreceptors원추형 광수용체에서 Ranbp2의 특정 제거 시 광수용체 세포 유형 간의 고유하고 비정형적인 고유 및 외인성 세포 사멸 경로Research Article Published on 2013-06-202022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Ablation Activation acute transverse myelitis affecting Apoptosis approaches arise Author base cascade caspase caspase-3 caspase-7 caspase-9 cause Cell cell death clinical manifestations cone cone photoreceptor contribute death degenerate degeneration demise develop Diseases disintegration downstream driving event expression extrinsic Factor followed by found Gene Genes Genetic genetic defect hallmark healthy heterogeneous implicated intrinsic intrinsically manifestation mechanism membrane permeability metalloproteinase modulation molecular mosaic multifunctional protein Mutation Myelitis necrotic neural retina neurodegeneration neurodegenerative neurodegenerative disorders Neuron neurons neuroprotection PARP1 pathway Pathways photoreceptor photoreceptors pleiotropic progression progression of disease promote Protein Ranbp2 rod rod photoreceptor rod photoreceptors rods spatiotemporal Specific Stressor subcellular therapeutic thought transverse myelitis Trigger triggered Tumor Type undergo underlying disease underlying diseases up-regulation [DOI] 10.1371/journal.pgen.1003555 PMC 바로가기 [Article Type] Research Article
Transient Oligomerization of the SARS-CoV N Protein – Implication for Virus Ribonucleoprotein PackagingResearch Article Published on 2013-05-232022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] acute respiratory syndrome Affect base C-terminal changes in Concentration coronavirus CTD cysteine residue domain electrostatic repulsion intrinsically mechanism mutant Mutation N protein nucleocapsid oligomer oligomerization Protein Region regulate SARS-CoV SARS-CoV N Transient viral genome [DOI] 10.1371/journal.pone.0065045 PMC 바로가기 [Article Type] Research Article
Structural Bases of Coronavirus Attachment to Host Aminopeptidase N and Its Inhibition by Neutralizing AntibodiesResearch Article Published on 2012-08-022022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] acute respiratory syndrome aminopeptidase aminopeptidase N antibody antigenic Antiviral APN attachment Author base binding blocked Cancer Cancer therapy Cell cell entry cell entry receptor cell membrane colds complex coronavirus CoV CoVs crystal structure determinant determine dimeric drugs ectodomain engage enteric diseases facilitate gastroenteritis Host host cells Human immune immune response in some Infection infections Infectious disease information inhibition Interaction membrane-bound neutralization Neutralizing antibodies neutralizing antibody Prevent Protein RBDs receptor Receptor binding receptor binding motif related reported residue respiratory diseases shown specificity spike glycoprotein Strains subsequent subset TGEV the RBD the receptor-binding domain the S protein unique Vaccines virus virus virus particle viruses [DOI] 10.1371/journal.ppat.1002859 PMC 바로가기 [Article Type] Research Article