SARS-CoV-2 Proteins Induce IFNG in Th1 Lymphocytes Generated from CD4+ Cells from Healthy, Unexposed Polish DonorsCommunication Published on 2020-11-122022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Asymptomatic BCG caused CD4+ CD4+ cell Cell cellular response Cellular responses changes in common cold coronavirus common cold Coronaviruses Course COVID-19 COVID-19 infection cross-reactivity Cytokine storm Cytokines death dependent on Deterioration exhibited explain expression healthy donor high variability IFN-γ IFNg Impaired Cellular Immunity induce Infection interferon gamma involved Lineage Mild symptom outbreak pathogenesis of COVID-19 Patient Population Protein reduction in SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 viral systemic inflammation Th1 Th1 lymphocyte Th1 response Th17 the SARS-CoV-2 virus vaccination [DOI] 10.3390/vaccines8040673 PMC 바로가기 [Article Type] Communication
Biological Rationale for the Repurposing of BCG Vaccine against SARS-CoV-2Article Published on 2020-11-062023-07-12 Journal: Journal of Proteome Research [Category] SARS, [키워드] BCG clinical study COVID-19 SARS-CoV-2 Vaccine [DOI] 10.1021/acs.jproteome.0c00410
Role of latent tuberculosis infections in reduced COVID-19 mortality: Evidence from an instrumental variable method analysisArticle Published on 2020-11-012023-07-12 Journal: Med Hypotheses [Category] SARS, [키워드] BCG COVID-19 Innate immunity Instrumental variable method latent tuberculosis infection trained immunity [DOI] 10.1016/j.mehy.2020.110214 PMC 바로가기
BCG vaccination early in life does not improve COVID-19 outcome of elderly populations, based on nationally reported dataArticle Published on 2020-11-012023-07-12 Journal: Letters in Applied Microbiology [Category] SARS, [키워드] BCG COVID-19 Mycobacterium tuberculosis vaccine SARS-CoV-2 TBC trained immunity Tuberculosis [DOI] 10.1111/lam.13365 PMC 바로가기
“Trained immunity” from Mycobacterium spp. exposure or BCG vaccination and COVID-19 outcomesOpinion Published on 2020-10-292022-10-29 Journal: PLoS Pathogens [Category] COVID-19, MERS, SARS, [키워드] age BCG BCG vaccination benefit Cell-mediated immunity comparable concerning confounding variables Confusion Control correlated correlation Coverage COVID-19 distribution epidemiological data European country evaluate Factor Heterologous implementation Inclusion Infection Intervention lack measure Mortality Mycobacterium outcome pandemic persistence Prevalence Protective protective role responsible resulting suggested Trial vaccination Vaccine variable with COVID-19 [DOI] 10.1371/journal.ppat.1008969 PMC 바로가기 [Article Type] Opinion
Childhood Immunization and COVID-19: An Early Narrative ReviewPublic Health Published on 2020-10-282022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] absence Adults age Analysis Anti-viral treatment arising association BCG childhood children clinical investigation COVID-19 COVID-19 pandemic Diseases effective Endemic genomic global public health groups Heterologous hypotheses immune response Immunity immunization immunological infect infected children less MMR narrative outcome protective effect protective role provide reported resulting review Safe SARS-CoV-2 severe symptom severity of symptom the disease the SARS-CoV-2 virus Topic vaccination Vaccine Vaccines virus [DOI] 10.3389/fpubh.2020.587007 PMC 바로가기 [Article Type] Public Health
Common childhood vaccines do not elicit a cross-reactive antibody response against SARS-CoV-2Research Article Published on 2020-10-282022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] adaptive immune responses Adults Anecdotal antibody BALB/c mice BCG childhood children common COVID-19 immunity cross-reactive cross-reactive antibody Diphtheria elicit Evidence Haemophilus influenzae incidence of COVID-19 indicated measles much lower negative correlation Neutralizing neutralizing antibody pertussis post vaccination provided Result rotavirus rubella SARS-CoV-2 SARS-COV-2 infection Seven tested Tetanus the disease vaccination Vaccine [DOI] 10.1371/journal.pone.0241471 PMC 바로가기 [Article Type] Research Article
Protection against SARS-CoV-2 by BCG vaccination is not supported by epidemiological analysesArticle Published on 2020-10-272022-10-04 Journal: Scientific Reports [Category] MERS, 유전자 메커니즘, 임상, [키워드] Analysis association Bacillus BCG BCG vaccination benefit boost clinical trial co-morbidities confounding variables correlation country COVD-19 COVID-19 COVID-19 outbreak death rate Diseases epidemiological epidemiological finding Evidence Health policy incidence of COVID-19 infection with SARS-CoV-2 initial Innate immunity Mortality Numerous Prevalence Prevent protection provide reduced Registered Respiratory tract diseases SARS-CoV-2 severity of COVID-19 significantly smoking Spread supported thought Tuberculosis Vaccine variable while [DOI] 10.1038/s41598-020-75491-x PMC 바로가기 [Article Type] Article
BCG revaccination of health workers in Brazil to improve innate immune responses against COVID-19: A structured summary of a study protocol for a randomised controlled trialCOVID-19에 대한 타고난 면역 반응을 개선하기 위해 브라질에서 의료 종사자의 BCG 재접종: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2020-10-262022-08-13 Journal: Trials [Category] MERS, SARS, 임상, [키워드] accompany activate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Admission Antibiotics antiviral immune response approved assigned Autoimmune Autoimmune diseases Bacillus BCG BCG revaccination BCG vaccination bcg vaccine blinded Blinding block blocks both groups Brazil Breastfeeding carried CFU Characteristics Chemotherapy childhood city clinical trial Committee Comorbidities Comorbidity confirmation Contact contact with control group Coronavirus-2 COVID-19 COVID-19 patient COVID-19 severity COVID-19 symptoms COVID-19 test cross-protection determined by diagnosed direct contact disease disease severity Diseases dissemination dose doses Effectiveness element elicited eligibility criteria Fever health worker health workers healthcare providers HIV hospital Hypothesis ICU identification number IgG and IgM IgM and IgG IgM test immunosuppressive IMPROVE in both group incidence incidence of COVID-19 Inclusion inclusion criteria India induce Infection infections information innate immune response investigator Laboratory lateral flow less macrophages medication meet memory monocyte Monocytes Mortality naso-oropharyngeal swab neutrophil Neutrophils NK NK cell number Nurses objective Open-label outcome outcomes pandemic parallel-group participant physiotherapists platform presenting Prevent Primary outcome Primary outcomes professional protocol randomisation randomised randomised controlled trial randomization Randomized receive recruit recruitment reduce Registered registration number researcher researchers respiratory revaccination right arm RT-PCR Sample size SARS-CoV-2 scar sealed Secondary objective Secondary objectives secondary outcome severe acute respiratory syndrome Coronavirus severity solid tumour specimen statistical analyses status steroid Study protocol Symptom symptomatic infection the disease the vaccine Trial Trial registration Tuberculosis two groups vaccination Vaccine virus virus infection virus infections was performed website WHO [DOI] 10.1186/s13063-020-04822-0 PMC 바로가기 [Article Type] Letter
Global impact of environmental temperature and BCG vaccination coverage on the transmissibility and fatality rate of COVID-19Research Article Published on 2020-10-222022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] 95% CI 95% confidence interval Bacillus BCG BCG vaccination category collected country Coverage COVID-19 COVID-19 infection death Efficacy Evidence exploratory study Fatality rate high temperature highest incidence incidence rate interquartile range IQR less mean temperature median Mortality multivariable Neonatal outcome pandemic Protective provide quartile regression analysis reported statistically significant statistically significant difference temperature Transmissibility vaccination was determined [DOI] 10.1371/journal.pone.0240710 PMC 바로가기 [Article Type] Research Article